1-Methylimidazole
- CAS No.
- 616-47-7
- Chemical Name:
- 1-Methylimidazole
- Synonyms
- N-METHYLIMIDAZOLE;1-methyl-1h-imidazole;MIM;MeIm;methyl imidazole;1H-Imidazole, 1-methyl-;N-methylimidazole (1-methylimidazole);1-Methylimdazole;N-methyl midazole;N-methyl glyoxaline
- CBNumber:
- CB1316726
- Molecular Formula:
- C4H6N2
- Molecular Weight:
- 82.1
- MDL Number:
- MFCD00005292
- MOL File:
- 616-47-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Methylimidazole | MX1123 | 4L | $922.5 |
| 1-Methylimidazole for synthesis | 8.05852 | 100mL | $70.5 |
| 1-Methylimidazole for synthesis | 8.05852 | 1L | $442 |
| 1-Methylimidazole ≥99%, purified by redistillation | 336092 | 1l | $433 |
| 1-Methylimidazole ≥99%, purified by redistillation | 336092 | 2l | $641 |
| More product size | |||
| Melting point | −60 °C(lit.) |
|---|---|
| Boiling point | 198 °C(lit.) |
| Density | 1.03 g/mL at 25 °C(lit.) |
| vapor pressure | 0.4 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 198 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 6.95(at 25℃) |
| Specific Gravity | 1.031 |
| color | Clear colorless to yellow |
| PH | 9.5-10.5 (50g/l, H2O, 20℃) |
| PH Range | 9.5 - 11.5 at 100 g/l at 20 °C |
| biological source | synthetic |
| explosive limit | 2.7-15.7%(V) |
| Water Solubility | Miscible with water. |
| Sensitive | Hygroscopic |
| BRN | 105197 |
| Henry's Law Constant | 6.9×101 mol/(m3Pa) at 25℃, Du et al. (2017) |
| Stability | Stable, but moisture sensitive. Incompatible with acids, acid anhydrides, strong oxidizing agents, moisture, carbon dioxide, acid chlorides. |
| InChI | 1S/C4H6N2/c1-6-3-2-5-4-6/h2-4H,1H3 |
| InChIKey | MCTWTZJPVLRJOU-UHFFFAOYSA-N |
| SMILES | Cn1ccnc1 |
| LogP | -0.19 at 25℃ |
| CAS DataBase Reference | 616-47-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | P4617QS63Y |
| NIST Chemistry Reference | 1H-Imidazole, 1-methyl-(616-47-7) |
| EPA Substance Registry System | 1H-Imidazole, 1-methyl- (616-47-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H314 | |||||||||
| Precautionary statements | P270-P280-P301+P312-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,Xn,F,T | |||||||||
| Risk Statements | 21/22-34-19-11-20/21/22-52/53-24-22-40-37-21 | |||||||||
| Safety Statements | 26-36-45-1/2-36/37/39-16-33-29-61 | |||||||||
| RIDADR | UN 3267 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NI7000000 | |||||||||
| F | 3-10 | |||||||||
| Autoignition Temperature | 977 °F | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332990 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 4 Oral Eye Dam. 1 Repr. 2 Skin Corr. 1B |
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| Toxicity | LD50 orally in Rabbit: 1144 mg/kg LD50 dermal Rabbit > 400 - < 640 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
1-Methylimidazole price More Price(98)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MX1123 | 1-Methylimidazole | 616-47-7 | 4L | $922.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 100mL | $70.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 1L | $442 | 2026-04-30 | Buy |
| Sigma-Aldrich | 336092 | 1-Methylimidazole ≥99%, purified by redistillation | 616-47-7 | 1l | $433 | 2026-04-30 | Buy |
| Sigma-Aldrich | 336092 | 1-Methylimidazole ≥99%, purified by redistillation | 616-47-7 | 2l | $641 | 2026-04-30 | Buy |
1-Methylimidazole Chemical Properties,Uses,Production
Chemical Properties
1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colorless to yellow liquid, with an amine-like odor. It is miscible with water. N-methylimidazole is an important raw material for the synthesis of pharmaceutical intermediates, used in the preparation of losartan, nizofenone, 1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride and naphazoline hydrochloride, etc. It is also used as a specialty solvent, a base, and as a precursor to some ionic liquids.
Uses
1-Methylimidazole is an aprotic solvent. It is a derivative of imidazole used in the production of pharmaceuticals, pesticides, ion exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It can also be used as a catalyst for the manufacture of polyurethane and a curing agent for epoxy resins. For example, when 1-methylimidazole is added to an aqueous diethylenetriamine (DETA) solution, high CO2 loading can be achieved through phase separation of the absorbent during CO2 absorption[1].
Definition
ChEBI: 1-methyl-1H-imidazole is a 1H-imidazole having a methyl substituent at the N-1 position. It is a metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.
Preparation
1-Methylimidazole is prepared mainly by two routes industrially. The main one is acid-catalysed methylation of imidazole by methanol. The second method involves the Radziszewski reaction from glyoxal, formaldehyde, and a mixture of ammonia and methylamine.
(CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O
The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation.
H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I
[H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI
General Description
This product has been enhanced for catalysis. 1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals, pesticides, ion-exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It is also used as a catalyst for manufacturing polyurethanes and a curing agent for epoxy resins.
Flammability and Explosibility
Not classified
Purification Methods
Dry it with sodium metal and then distil it. Store it at 0o under dry argon. The picrate has m 159.5-160.5o (from H2O). [Beilstein 23 III/IV 568.]
Toxicity evaluation
Acute toxicity:Harmful if swallowed. Toxic in contact with skin. LD50 Oral:1144 mg/kg, LD50 Dermal:400-640 mg/kg.
References
[1] You J, et al. Effect of 1-Methylimidazole on CO2 Absorption by Diethylenetriamine (DETA) Aqueous Solutions. Chemical Engineering & Technology, 2017; 40: 2238-2242.
1-Methylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong DYCK Biotech Co.,LTD | +86-15376072011 | sales3@dyckbiotech.com | China | 3 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055326116 | sales1@nuowei-chem.com | China | 1627 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Yiduo Import and Export Co., Ltd. | joycedemei1505@outlook.com | China | 215 | 58 | |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5225 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Zibo Shiji Zhonglian Medical Technology Co., Ltd. | 15069388126 15069388126; | sales@sjzlpharm.com | China | 65 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
Related articles
- 1-Methylimidazole: An Overview
- 1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals....
- Oct 24，2024
View Lastest Price from 1-Methylimidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-24 | 1-Methylimidazole
616-47-7
|
$75.00-100.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-06-24 | 1-Methylimidazole
616-47-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-06-15 | 1-Methylimidazole
616-47-7
|
1KG | 99% | 500mg/year | Jinan Finer Chemical Co., Ltd |
-
- 1-Methylimidazole
616-47-7
- $75.00-100.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 1-Methylimidazole
616-47-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 1-Methylimidazole
616-47-7
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
