6-HYDRAZINONICOTINIC ACID
- CAS No.
- 133081-24-0
- Chemical Name:
- 6-HYDRAZINONICOTINIC ACID
- Synonyms
- MS-3627;6-Hydrazinicotinic acid;HYDRALINK 6-HNA REAGENT;6-HydrazinonicotinicAci;6-HYDRAZINONICOTINIC ACID;6-Hydrazinylnicotinic acid;HYDRALINK(TM) 6-HNA REAGENT;6-hydrazineylnicotinic acid;6-HYDRAZINO-NICOTINIC ACID, 98+%;6-Hydrazino-3-pyridinecarboxylic acid
- CBNumber:
- CB1316892
- Molecular Formula:
- C6H7N3O2
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD03788692
- MOL File:
- 133081-24-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Hydrazino-3-pyridinecarboxylic acid ≥98%(HPLC) | 28787 | 1G | $79.22 |
| 6-Hydrazino-3-pyridinecarboxylic acid ≥98%(HPLC) | 28787 | 5G | $239.46 |
| 6-Hydrazino-3-pyridinecarboxylic acid ≥98%(HPLC) | 28787 | 25G | $882.32 |
| 6-Hydrazinonicotinic acid 97.0% | H7591 | 1g | $23 |
| 6-Hydrazinonicotinic acid 97.0% | H7591 | 5g | $29 |
| More product size | |||
| Melting point | 0°C |
|---|---|
| Boiling point | 0°C |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Flash point | 0°C |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Aqueous Base (Slightly, Heated, Sonicated) |
| pka | 4.72±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow to Light Yellow |
| InChI | InChI=1S/C6H7N3O2/c7-9-5-2-1-4(3-8-5)6(10)11/h1-3H,7H2,(H,8,9)(H,10,11) |
| InChIKey | HBBSDZXXUIHKJE-UHFFFAOYSA-N |
| SMILES | C1=NC(NN)=CC=C1C(O)=O |
| CAS DataBase Reference | 133081-24-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25 |
| HazardClass | IRRITANT |
6-HYDRAZINONICOTINIC ACID price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chem-Impex | 28787 | 6-Hydrazino-3-pyridinecarboxylic acid ≥98%(HPLC) | 133081-24-0 | 1G | $79.22 | 2026-05-19 | Buy |
| Chem-Impex | 28787 | 6-Hydrazino-3-pyridinecarboxylic acid ≥98%(HPLC) | 133081-24-0 | 5G | $239.46 | 2026-05-19 | Buy |
| Chem-Impex | 28787 | 6-Hydrazino-3-pyridinecarboxylic acid ≥98%(HPLC) | 133081-24-0 | 25G | $882.32 | 2026-05-19 | Buy |
| Synthonix | H7591 | 6-Hydrazinonicotinic acid 97.0% | 133081-24-0 | 1g | $23 | 2026-05-06 | Buy |
| Synthonix | H7591 | 6-Hydrazinonicotinic acid 97.0% | 133081-24-0 | 5g | $29 | 2026-05-06 | Buy |
6-HYDRAZINONICOTINIC ACID Chemical Properties,Uses,Production
Synthesis
5326-23-8
133081-24-0
Example 72: Synthesis of 3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonyl chloride: 1. 6-Chloronicotinic acid (20 g, 127 mmol) was used as raw material, which was dissolved in 200 mL of ethanol and hydrazine hydrate (14.8 mL, 317 mmol) was added. The reaction mixture was refluxed overnight, cooled to room temperature and precipitated as a solid, which was collected by filtration and washed with petroleum ether/ethyl acetate (2:1) to give 18 g of 6-hydrazinonicotinic acid as a yellow solid (yield: 91%).1H NMR (DMSO, 400 MHz) δ: 8.52 (s, 1H), 7.88 (dd, J = 2.0 Hz, 8.8 Hz, 1H), 6.63 (d, J = 8.8 Hz, 1H). 2. 6-Hydrazinonicotinic acid (18 g, 117 mmol) was suspended in 100 mL of anhydrous tetrahydrofuran, anhydrous pyridine (23 g, 293 mmol) was added, and after stirring at room temperature for 15 min, bis(trichloromethyl) carbonate (80 g, 270 mmol) was slowly added. The reaction mixture was stirred at room temperature overnight, methanol was added and stirring was continued for 15 h. A solid was precipitated, which was collected by filtration and washed with petroleum ether/ethyl acetate (1:1) to afford 20 g of dimethyl 3-oxo-[1,2,4]triazolo[4,3-a]pyridine-2,6(3H)-dicarboxylate.1H NMR (CDCl3, 400 MHz) δ: 3.95 (s, 3H) , 4.13 (s, 1H), 7.13 (dd, J = 1.6 Hz, 10 Hz, 1H), 7.71 (dd, J = 1.6 Hz, 10 Hz, 1H), 8.55 (t, J = 2 Hz, 1H). 3. 3-Oxo-[1,2,4]triazolo[4,3-a]pyridine-2,6(3H)-dicarboxylic acid dimethyl ester (10 g, 40 mmol) was dissolved in 60 mL of tetrahydrofuran, 10 mL of water and LiOH-H2O (4.8 g, 114 mmol) were added, and after stirring at room temperature for 6 h, the tetrahydrofuran was removed by vacuum concentration, and the tetrahydrofuran was adjusted to pH 2 by adding 1 mL of HCl solution. The pH was adjusted to 2. A solid was precipitated and collected to give 11 g of 3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid, which was used directly in the next step.1H NMR (DMSO, 400 MHz) δ: 7.23 (d, J = 10 Hz, 1H), 7.48 (dd, J = 1.6 Hz, 10 Hz, 1H), 8.25 (s, 1H), 8.25 (s, 1H), 8.25 (s, 1H) and 8.25 (s, 1H). 8.25 (s, 1H), 9.13 (s, 1H), 12.89 (s, 1H). 4. 3-Oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (3 g, 16.8 mmol) was dissolved in 60 mL of anhydrous dichloromethane, oxalyl chloride (8.8 g, 74 mmol) and 1 mL of DMF were added, and the mixture was concentrated after stirring for 6 hours at room temperature to give 3 g of the title compound, 3-oxo-2,3-dihydro-[1 ,2,. 4]triazolo[4,3-a]pyridine-6-carbonyl chloride as a gray solid, which was used directly in the next reaction.
References
[1] Letters in Organic Chemistry, 2014, vol. 11, # 3, p. 208 - 214
[2] Patent: WO2010/96722, 2010, A1. Location in patent: Page/Page column 54-55
[3] Polish Journal of Chemistry, 2004, vol. 78, # 7, p. 951 - 959
[4] Patent: WO2017/177144, 2017, A1. Location in patent: Page/Page column 33; 39
[5] Pharmazie, 2006, vol. 61, # 4, p. 269 - 273
6-HYDRAZINONICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29816 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
View Lastest Price from 6-HYDRAZINONICOTINIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-01 | 6-hydrazinonicotinic acid
133081-24-0
|
US $0.00 / KG | 1KG | 98% | 1000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-11-18 | 6-HYDRAZINONICOTINIC ACID
133081-24-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2022-01-26 | 6-Hydrazinonicotinic acid
133081-24-0
|
US $0.00 / KG | 1KG | 98.9% | 100 tons | Honest Joy Holdings Limited |
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- 6-hydrazinonicotinic acid
133081-24-0
- US $0.00 / KG
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 6-HYDRAZINONICOTINIC ACID
133081-24-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 6-Hydrazinonicotinic acid
133081-24-0
- US $0.00 / KG
- 98.9%
- Honest Joy Holdings Limited
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