4-Amino-3-methylbenzonitrile
- CAS No.
- 78881-21-7
- Chemical Name:
- 4-Amino-3-methylbenzonitrile
- Synonyms
- 4-cyano-o-toluidine;4-amino-m-tolunitrile;2-Amino-5-cyanotoluene;4-cyano-2-methylaniline;2-Methyl-4-Cyanoaniline;3-Methyl-4-Aminobenzonitrile;4-AMINO-3-METHYLBENZONITRILE;Benzonitrile, 4-amino-3-methyl-;4-Amino-3-methylbenzonitrile >4-AMINO-3-METHYLBENZONITRILE, 98+%
- CBNumber:
- CB1327685
- Molecular Formula:
- C8H8N2
- Molecular Weight:
- 132.16
- MDL Number:
- MFCD02093969
- MOL File:
- 78881-21-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Amino-3-methylbenzonitrile AldrichCPR | CDS001194 | 5MG | $73.1 |
| 4-Amino-3-methylbenzonitrile >97.0%(GC) | A2107 | 1g | $46 |
| 4-Amino-3-methylbenzonitrile >97.0%(GC) | A2107 | 5g | $138 |
| 4-Amino-3-methylbenzonitrile | OR2931 | 5g | $101 |
| 4-Amino-3-methylbenzonitrile | 3737-1-Y3 | 5G | $111 |
| More product size | |||
| Melting point | 93-94°C |
|---|---|
| Boiling point | 304.5±30.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 1.58±0.10(Predicted) |
| color | White to Gray to Brown |
| BRN | 3235728 |
| InChI | 1S/C8H8N2/c1-6-4-7(5-9)2-3-8(6)10/h2-4H,10H2,1H3 |
| InChIKey | MBZDCUMFFPWLTJ-UHFFFAOYSA-N |
| SMILES | Cc1cc(ccc1N)C#N |
| CAS DataBase Reference | 78881-21-7(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H331-H335-H301-H315-H319 | |||||||||
| Precautionary statements | P261-P304+P340-P305+P351+P338-P501a-P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-43-20/21-36/37/38 | |||||||||
| Safety Statements | 22-36/37/39-36/37-26-9 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Amino-3-methylbenzonitrile price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS001194 | 4-Amino-3-methylbenzonitrile AldrichCPR | 78881-21-7 | 5MG | $73.1 | 2025-07-31 | Buy |
| TCI Chemical | A2107 | 4-Amino-3-methylbenzonitrile >97.0%(GC) | 78881-21-7 | 1g | $46 | 2025-07-31 | Buy |
| TCI Chemical | A2107 | 4-Amino-3-methylbenzonitrile >97.0%(GC) | 78881-21-7 | 5g | $138 | 2025-07-31 | Buy |
| Apolloscientific | OR2931 | 4-Amino-3-methylbenzonitrile | 78881-21-7 | 5g | $101 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3737-1-Y3 | 4-Amino-3-methylbenzonitrile | 78881-21-7 | 5G | $111 | 2021-12-16 | Buy |
4-Amino-3-methylbenzonitrile Chemical Properties,Uses,Production
Uses
4-Amino-3-methylbenzonitrile is a useful research chemical used in organic synthesis and other chemical processes.
Chemical Properties
Light yellow powder
Synthesis
96784-54-2
78881-21-7
General procedure for the synthesis of 4-amino-3-methylbenzonitrile from 3-methyl-4-nitrobenzonitrile: 9.89 g (61 mmol, 1 equiv.) of 3-methyl-4-nitrobenzonitrile was added to a stirred 100 mL tetrahydrofuran (THF) solution at room temperature. Subsequently, 1 g of 10% palladium carbon catalyst was added. Next, 25 mL of methanol was added. The reaction system was placed in a hydrogenation unit and the reaction was carried out at a hydrogen pressure of 50 psi. When hydrogen consumption was no longer observed, the reaction was stopped and filtered through diatomaceous earth to remove the catalyst. The product was purified by column chromatography using a 1:1 mixture of hexane and dichloromethane as the mobile phase. 7.5 g of 4-amino-3-methylbenzonitrile in beige powder form was finally obtained in 93% yield. The 1H-NMR (DMSO-d6) data of the product were as follows: δ 2.27 (3H, s), 6.06 (2H, s), 6.41 (1H, d), 6.46 (1H, s), 7.30 (1H, d).
References
[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 18, p. 3572 - 3587
[2] Patent: US2017/44373, 2017, A1. Location in patent: Paragraph 0227; 0228
[3] Patent: US6353006, 2002, B1. Location in patent: Page column 23
[4] Patent: US2005/54655, 2005, A1. Location in patent: Page/Page column 15
[5] Patent: US2004/44203, 2004, A1. Location in patent: Page 27
4-Amino-3-methylbenzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 4-Amino-3-methylbenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-30 | 4-Amino-3-methylbenzonitrile
78881-21-7
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2021-08-12 | 4-Amino-3-methylbenzonitrile
78881-21-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-14 | 4-Amino-3-methylbenzonitrile
78881-21-7
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-Amino-3-methylbenzonitrile
78881-21-7
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Amino-3-methylbenzonitrile
78881-21-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Amino-3-methylbenzonitrile
78881-21-7
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
