MGA271
- CAS No.
- 1353485-38-7
- Chemical Name:
- MGA271
- Synonyms
- Enoblituzumab;MGA271;MGA271|||TJ-271;Enoblituzumab (anti-CD276);Research Grade Enoblituzumab;Research Grade Enoblituzumab(DHJ04001)
- CBNumber:
- CB13303237
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Enoblituzumab | CLA1041 | 1mg | $1375 |
| Enoblituzumab | CLA1041 | 5mg | $2406.25 |
| Enoblituzumab | CLA1041 | 10mg | $4042.5 |
| Enoblituzumab 99.16% | CS-0105063 | 1mg | $379 |
| Enoblituzumab 99.16% | CS-0105063 | 5mg | $986 |
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | M6030H73N9 |
| NCI Drug Dictionary | enoblituzumab |
MGA271 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CLA1041 | Enoblituzumab | 1353485-38-7 | 1mg | $1375 | 2026-06-04 | Buy |
| Biosynth | CLA1041 | Enoblituzumab | 1353485-38-7 | 5mg | $2406.25 | 2026-06-04 | Buy |
| Biosynth | CLA1041 | Enoblituzumab | 1353485-38-7 | 10mg | $4042.5 | 2026-06-04 | Buy |
| ChemScene | CS-0105063 | Enoblituzumab 99.16% | 1353485-38-7 | 1mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0105063 | Enoblituzumab 99.16% | 1353485-38-7 | 5mg | $986 | 2026-06-04 | Buy |
MGA271 Chemical Properties,Uses,Production
Uses
Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators[1].
in vivo
Enoblituzumab (5 mg/kg; i.v.; single dose) exhibits estimated half-life of 249 hours with a Cmax of 43 mg/mL in mice (mCD16-/-hCD16A+) that murine CD16 gene knocked out and are transgenic for human CD16A-158F[3].
Enoblituzumab (0.1-10 mg/kg; i.v.; once weekly; 5 weeks) exhibits potent antitumor activity in B7-H3-expressing xenograft mice models of renal cell and bladder carcinoma[3].
| Animal Model: | mCD16-/-hCD16A+ mice implanted with A498 renal cell carcinoma, 786-0 renal cell carcinoma, or HT-1197 bladder carcinoma cells (s.c.)[3] |
| Dosage: | 1 mg/kg, 5 mg/kg, 10 mg/kg |
| Administration: | Intravenous injection; once weekly; 5 weeks |
| Result: | Significantly inhibited tumor growth at doses of 1 mg/kg or greater with once weekly treatment. Achieved a cytostatic response at 5 or 10 mg/kg until day 52, after which the average tumor volume of the 5 mg/kg treatment group remained near predose administration levels, whereas a nonsignificant trend toward relapse exhibited in the 10 mg/kg group. |
References
[1] Hińcza-Nowak K, et al. Immune Profiling of Medullary Thyroid Cancer-An Opportunity for Immunotherapy. Genes (Basel). 2021 Sep 28;12(10):1534. DOI:10.3390/genes12101534
[2] Chapoval, et al. Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors. Russ J Bioorg Chem 45, 321–334 (2019).
[3] Loo D, et al. Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Clin Cancer Res. 2012 Jul 15;18(14):3834-45. DOI:10.1158/1078-0432.CCR-12-0715
MGA271 Preparation Products And Raw materials
Raw materials
Preparation Products
MGA271 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57472 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7999 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10307 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7234 | 58 |
View Lastest Price from MGA271 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-13 | Enoblituzumab
1353485-38-7
|
$195.00-692.00 | 95.00% | 10g | TargetMol Chemicals Inc. |
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- Enoblituzumab
1353485-38-7
- $195.00-692.00
- 95.00%
- TargetMol Chemicals Inc.
