LMP744
- CAS No.
- 308246-52-8
- Chemical Name:
- LMP744
- Synonyms
- LMP744;NSC-706744;LMP744,LMP-744;LMP744 (MJ-III65;5H-[1,3]Dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-;6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4,5:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione(WXG02929);20-{3-[(2-hydroxyethyl)amino]propyl}-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,1?.0?,?.013,1?]icosa-1(12),2(10),3,8,13(18),14,16-heptaene-11,19-dione
- CBNumber:
- CB13339672
- Molecular Formula:
- C24H24N2O7
- Molecular Weight:
- 452.45656
- MDL Number:
- MFCD32645133
- MOL File:
- 308246-52-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| LMP744 >98% | orb573434 | 100mg | $1356.6 |
| LMP744 >98% | orb573434 | 250mg | $2541.5 |
| LMP744 >98% | orb573434 | 1g | $4766.8 |
| Melting point | 231-234 °C |
|---|---|
| Boiling point | 748.1±60.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 14.79±0.10(Predicted) |
| color | Brown to dark brown |
| FDA UNII | 29BY7HQV0T |
LMP744 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb573434 | LMP744 >98% | 308246-52-8 | 100mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573434 | LMP744 >98% | 308246-52-8 | 250mg | $2541.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573434 | LMP744 >98% | 308246-52-8 | 1g | $4766.8 | 2021-12-16 | Buy |
LMP744 Chemical Properties,Uses,Production
Uses
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
in vivo
LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].
| Animal Model: | Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1]. |
| Dosage: | 10, 25, or 50 mg/kg/week, 4 weeks |
| Administration: | I.V. push via tail vein |
| Result: | Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity. |
IC 50
Top1
References
[1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 2007 Nov 1;67(21):10397-405. DOI:10.1158/0008-5472.CAN-07-0938
LMP744 Preparation Products And Raw materials
Raw materials
Preparation Products
LMP744 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19957 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4817 | 55 | |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1946 | 55 |
| Suzhou Ran enzyme Biotechnology Co., Ltd. | 0512-0512-62793604 18015430729 | 116667374@qq.com | China | 132 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-037163312495,13303845143 13303845143 | 3001379618@qq.com | China | 10197 | 58 |
