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5-Amino-1,3,4-thiadiazole-2-thiol

5-Amino-1,3,4-thiadiazole-2-thiol structure

CAS No.: 2349-67-9

Chemical Name:: 5-Amino-1,3,4-thiadiazole-2-thiol

Synonyms: 2-Amino-5-mercapto-1,3,4-thiadiazole;2-Amino-5-mercapto-1,3,4-thiad;2-Mercapto-5-amino-1,3,4-thiadiazole;1,3,4-Thiadiazole-2(3H)-thione, 5-amino-;EAMTD;nsc21402;NSC 21402;usafpd-25;USAF pd-25;Acetazolamide EP Impurity G

CBNumber:: CB1360123

Molecular Formula:: C2H3N3S2

Molecular Weight:: 133.2

MDL Number:: MFCD00003108

MOL File:: 2349-67-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:55

Product description	Number	Pack Size	Price
5-Amino-1,3,4-thiadiazole-2-thiol 98%	127906	50g	$88.6
2-Amino-5-mercapto-1,3,4-thiadiazole >98.0%(HPLC)(T)	A0425	25g	$22
2-Amino-5-mercapto-1,3,4-thiadiazole >98.0%(HPLC)(T)	A0425	500g	$187
5-Amino-1,3,4-thiadiazole-2-thiol	A633300	1g	$55
2-Amino-5-thio-1,3,4-thiadiazole 99%	OR28655	100g	$56
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5-Amino-1,3,4-thiadiazole-2-thiol Properties

Melting point	235 °C (dec.)(lit.)
Boiling point	242.3±23.0 °C(Predicted)
Density	1.503 (estimate)
refractive index	1.5800 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	2g/l
pka	7.80±0.20(Predicted)
form	Powder
color	White or pale yellow to cream
PH	3.9 (2g/l, H2O, 20℃)
Water Solubility	insoluble
BRN	81728
InChI	1S/C2H3N3S2/c3-1-4-5-2(6)7-1/h(H2,3,4)(H,5,6)
InChIKey	GDGIVSREGUOIJZ-UHFFFAOYSA-N
SMILES	Nc1nnc(S)s1
CAS DataBase Reference	2349-67-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	B1HEG7V21S
NIST Chemistry Reference	2-Amino-5-mercapto-1,3,4-thiadiazole(2349-67-9)
EPA Substance Registry System	1,3,4-Thiadiazole-2(3H)-thione, 5-amino- (2349-67-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P301+P312+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22-20/21/22

Safety Statements

26-36-36/37

WGK Germany

RTECS

XI4550000

9-13-23

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

5-Amino-1,3,4-thiadiazole-2-thiol price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	127906	5-Amino-1,3,4-thiadiazole-2-thiol 98%	2349-67-9	50g	$88.6	2023-01-07	Buy
TCI Chemical	A0425	2-Amino-5-mercapto-1,3,4-thiadiazole >98.0%(HPLC)(T)	2349-67-9	25g	$22	2025-07-31	Buy
TCI Chemical	A0425	2-Amino-5-mercapto-1,3,4-thiadiazole >98.0%(HPLC)(T)	2349-67-9	500g	$187	2025-07-31	Buy
TRC	A633300	5-Amino-1,3,4-thiadiazole-2-thiol	2349-67-9	1g	$55	2021-12-16	Buy
Apolloscientific	OR28655	2-Amino-5-thio-1,3,4-thiadiazole 99%	2349-67-9	100g	$56	2021-12-16	Buy

Product number	Packaging	Price	Buy
127906	50g	$88.6	Buy
A0425	25g	$22	Buy
A0425	500g	$187	Buy
A633300	1g	$55	Buy
OR28655	100g	$56	Buy

5-Amino-1,3,4-thiadiazole-2-thiol Chemical Properties,Uses,Production

Chemical Properties

White or pale yellow to cream powder

Uses

5-Amino-1,3,4-thiadiazole-2-thiol is a thiadiazole derivative with antibacterial acitivity used in the preparation of herbicides as well as carbonic anhydrase inhibitors.

Uses

5-amino-1,3,4-thiadiazole-2-thiol was used to prepare new amines exhibiting anti-convulsant activity.

Synthesis

75-15-0

79-19-6

2349-67-9

2-Amino-5-mercapto-1,3,4-thiadiazole was synthesized as follows: in a three-necked flask equipped with a stirrer, 5.5 g (0.06 mol) of aminothiourea, 20 mL of N,N-dimethylformamide (DMF), and 3 mL (0.1 mol) of carbon disulfide were added sequentially. The reaction mixture was heated to reflux and maintained for 4 hours. After completion of the reaction, the mixture was cooled to room temperature. To the reaction mixture was added 40 mL of 2 mol/L sodium hydroxide solution followed by decolorization. After decolorization, concentrated hydrochloric acid was slowly added to acidic conditions to precipitate the crude product. The crude product was purified by recrystallization from 50% ethanol to give 5.7 g of bright yellow needle-like crystals of 2-amino-5-mercapto-1,3,4-thiadiazole in 67.4% yield.

References

[1] Journal of Chemical Research, 2010, # 11, p. 619 - 621
[2] Chemical Biology and Drug Design, 2012, vol. 80, # 4, p. 598 - 604
[3] European Journal of Medicinal Chemistry, 2006, vol. 41, # 8, p. 918 - 924
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 2, p. 241 - 246
[5] Chemical Biology and Drug Design, 2013, vol. 81, # 5, p. 666 - 673

5-Amino-1,3,4-thiadiazole-2-thiol Preparation Products And Raw materials

Raw materials

2-Mercapto-5-methyl-1,3,4-thiadiazole Hydrazine sulfate Calcium phosphate RHENIUM Hydrazodicarbothioamide

Ammonium thiocyanate Carbon disulfide thiosemicarbazide

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Preparation Products

2-(ACETAMIDO)-5-(CHLOROSULFONYL)-1,3,4-THIADIAZOLE 2-Acetylamino-5-mercapto-1,3,4-thiadiazole 2-Amino-1,3,4-thiadiazole 2-AMINO-5-(METHYLTHIO)-1,3,4-THIADIAZOLE 5-{[(4-methylphenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-amine

5-(Isopropylthio)-1,3,4-thiadiazol-2-amine ethyl N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamate ETHYL 2-[(5-AMINO-1,3,4-THIADIAZOL-2-YL)THIO]ACETATE

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5-Amino-1,3,4-thiadiazole-2-thiol Suppliers

Global( 475)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8749	58
Hebei Dangtong Import and export Co LTD	+86-86-4001020630 +8619831957301	admin@hbdangtong.com	China	998	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13822	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21595	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2953	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	287	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Dangtong Import and export Co LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Hebei Jimi Trading Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58

View Lastest Price from 5-Amino-1,3,4-thiadiazole-2-thiol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-06	5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9	US $1.00 / kg	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-02-25	5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9	US $21.00-15.00 / kg	10kg	98%	300tons	Hebei Dangtong Import and export Co LTD
2025-04-04	5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

5-Amino-1,3,4-thiadiazole-2-thiol
2349-67-9
US $1.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Amino-1,3,4-thiadiazole-2-thiol
2349-67-9
US $21.00-15.00 / kg
98%
Hebei Dangtong Import and export Co LTD

5-Amino-1,3,4-thiadiazole-2-thiol
2349-67-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

5-Amino-1,3,4-thiadiazole-2-thiol Spectrum

5-Amino-1,3,4-thiadiazole-2-thiol(2349-67-9)MS 5-Amino-1,3,4-thiadiazole-2-thiol(2349-67-9)¹HNMR 5-Amino-1,3,4-thiadiazole-2-thiol(2349-67-9)¹³CNMR 5-Amino-1,3,4-thiadiazole-2-thiol(2349-67-9)IR1 5-Amino-1,3,4-thiadiazole-2-thiol(2349-67-9)IR2 5-Amino-1,3,4-thiadiazole-2-thiol(2349-67-9)Raman

2349-67-9(5-Amino-1,3,4-thiadiazole-2-thiol)Related Search:

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ACETYLAMINE(2-)-5-MERCAPTO-1,3,4-THIADAZOLE 1,3,4-Thiadiazole-2(3H)-thione, 5-amino- 1,3,4-Thiadiazole-2-thiol, 5-amino- 5-Amino-2-mercapto-1,3,4-thiadiazole 5-Amino-2-thiol-1,3,4-thiadiazole 5-Amino-3H-[1,3,4]thiadiazole-2-thione delta2-1,3,4-Thiadiazoline-2-thiol, 5-imino- NSC 21402 nsc21402 USAF pd-25 usafpd-25 EAMTD AMTD 2-Amino-5-mercapto-1,3,4-thiadiazole Acetazolamide EP Impurity G 2-amino-5-mercapto-1,3,4-thiiodiazole 5-amino-1,3,,4-thialiazoline-2(3H)-thione 2-Amino-5-mercapto-1,3,4-thiad 2-Amino-1,3,4-thiadiazole-5-mercaptan 2-Amino-1,3,4-thiadiazole-5-thiol 2-Amino-5-mercapto-1,3,4-thiadiazole(AMTD) 2-Amino-5-mercaptothiadiazole 2-amino-delta(2)-1,3,4-thiadiazoline-5-thione 2-Amino-delta2-1,3,4-thiadiazoline-5-thione 2-Mercapto-5-amino-1,3,4-thiadiazole 2-Thiol-5-amino-1,3,4-thiadiazole 3,4-Thiadiazole-2(3H)-thione,5-amino-1 Pesticide InterMediates 2-amino-5-mercapto-1,3,4-thiadiazol AMino - 5-2 - Mercapto - 1 and 4 - consult in 1 5-Amino-1,3,4-thiadiazole-2-thiol 98% 2-Amino-5-mercapto-1,3,4-thiadiazole for synthesis 5-Amino-1,3,4-thiadiazole-2(3H)-thione Solution, 100ppm Acetazolamide Impurity 7(Acetazolamide EP Impurity G) 5-Amino-1,3,4-thiadiazoL e-2-thioL 2-Amino-5-mercapto-1,3,4-thiadiazole 5-Amino-1,3,4-thiadiazole-2-thiol 4-thiadiazole-2(3h)-thione,5-amino-3 4-thiadiazole-2-thiol,5-amino-3 5-amino-1,3,4-thiadiazole-2(3h)-thione 5-Amino-1,3,4-thiadiazoline-2-thione 2-amino-5-mrecapto-1,3,4-thiadiazol 2-AMINO-5-MERCAPTO-1,3,4-THIADIAZOLE /AMT 5-Amino-1,3,4-thiadiazole-2-thiol,98% 5-Amino-1,3,4-thiadi 2-AMino-5-Mercapto-1 5-AMino-1,3,4-thiadiazole-2-thiol, 98% 25GR 5-AMino-1,3,4-thiadiazole-2-thiol, 98% 50GR 2-AMINO-5-MERCAPTO-1,3,4-THIADIAZOLE FOR 2-Amino-5-mercapto-1,3,4-thiadiazole, 5-Amino-1,3,4-thiadiazole-2-thiol 2-Amino-5-thio-1,3,4-thiadiazole 2-Amino-5-mercapto-1,3,4-thiadiazole, 98+% 5-Amino-1,3,4-thiazole-2-thiol 2-amino thiadiazole-5-thiol 5-Mercapto-1,3,4-thiadiazole-2-amine 5-Mercapto-2-amino-1,3,4-thiadiazole 2-amino-5-mercapto-1,3,4-triazole 2-Amino-5-mercapto-1,3,4-thiadiazole >