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3-Fluoro-2-hydroxybenzaldehyde

3-Fluoro-2-hydroxybenzaldehyde structure

CAS No.: 394-50-3

Chemical Name:: 3-Fluoro-2-hydroxybenzaldehyde

Synonyms: 3-FLUOROSALICYLALDEHYDE;3-Fluoro-2-hydroxybe;3-fluorosalicyldadehyde;1-Fluoro-6-formylphenol;3-Fluorosalicylaldehyde>3-Fluorosalicylaldehyde,98%;3-Fluorosalicylaldehyde ,99%;5-Fluoro-3-nitroacetophenone;3-FLUORO-2-HYDROXYBENZALDEHYDE;2-Hydroxy-3-fluorobenzaldehyde

CBNumber:: CB1367319

Molecular Formula:: C7H5FO2

Molecular Weight:: 140.11

MDL Number:: MFCD00003319

MOL File:: 394-50-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:38

Product description	Number	Pack Size	Price
3-Fluorosalicylaldehyde 97%	319805	1g	$94.7
3-Fluorosalicylaldehyde 97%	319805	250mg	$95.5
3-Fluorosalicylaldehyde >98.0%(GC)	F0625	1g	$59
3-Fluorosalicylaldehyde >98.0%(GC)	F0625	5g	$173
3-Fluoro-2-hydroxybenzaldehyde	F598025	100mg	$75
More product size

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3-Fluoro-2-hydroxybenzaldehyde Properties

Melting point	68-70 °C(lit.)
Boiling point	176.2±20.0 °C(Predicted)
Density	1.350±0.06 g/cm3(Predicted)
storage temp.	2-8°C, stored under nitrogen
Water Solubility	Insoluble in water
pka	6.91±0.10(Predicted)
form	Crystalline Powder
color	White to light yellow
Sensitive	Air Sensitive
BRN	1932806
InChI	InChI=1S/C7H5FO2/c8-6-3-1-2-5(4-9)7(6)10/h1-4,10H
InChIKey	NWDHTEIVMDYWQJ-UHFFFAOYSA-N
SMILES	C(=O)C1=CC=CC(F)=C1O
CAS DataBase Reference	394-50-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29124990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

3-Fluoro-2-hydroxybenzaldehyde price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	319805	3-Fluorosalicylaldehyde 97%	394-50-3	1g	$94.7	2022-05-15	Buy
Sigma-Aldrich	319805	3-Fluorosalicylaldehyde 97%	394-50-3	250mg	$95.5	2022-05-15	Buy
TCI Chemical	F0625	3-Fluorosalicylaldehyde >98.0%(GC)	394-50-3	1g	$59	2026-04-30	Buy
TCI Chemical	F0625	3-Fluorosalicylaldehyde >98.0%(GC)	394-50-3	5g	$173	2026-04-30	Buy
TRC	F598025	3-Fluoro-2-hydroxybenzaldehyde	394-50-3	100mg	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
319805	1g	$94.7	Buy
319805	250mg	$95.5	Buy
F0625	1g	$59	Buy
F0625	5g	$173	Buy
F598025	100mg	$75	Buy

3-Fluoro-2-hydroxybenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystalline powder

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 2502, 1946 DOI: 10.1021/ja01216a020

Synthesis

109-72-8

2-(2-broMo-5-Methoxyphenyl)-1,3-dioxolane

98015-07-7

394-50-3

A hexane solution of n-butyllithium (17.07 mL, 1.42 M, 25.1 mmol) was slowly added dropwise to a stirred solution of 2-(2-bromo-5-methoxyphenyl)-1,3-dioxolane (5.00 g, 19.3 mmol) dissolved in dry tetrahydrofuran (60 mL) at -78°C. The reaction mixture was stirred continuously at -78 °C for 30 min before being quenched by the addition of iodomethane (2.40 mL, 38.6 mmol). After quenching, the solution was continued stirring at -78 °C for 20 min, followed by termination of the reaction with saturated aqueous ammonium chloride solution (60 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography using hexane:ethyl acetate (10:1) as eluent to afford the light yellow oily target product 3-fluoro-2-hydroxybenzaldehyde (3.07 g, 82% yield). Thin layer chromatography showed an Rf value of 0.40 (Expanding agent: hexane:ethyl acetate, 10:1). The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 7.20-6.99 (2H, m, Ar-H), 6.75 (1H, dd, Ar-H), 5.92 (1H, s, CH), 4.20-4.01 (4H, m, 2 × CH2), 3.80 (3H, s, OCH3), 2.32 (3H, s, CH3) .

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 31

3-Fluoro-2-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

n-Butyllithium 2-(2-broMo-5-Methoxyphenyl)-1,3-dioxolane

Preparation Products

Benzenemethanol, 3-fluoro-2-methoxy- (9CI) 7-FLUORO INDAZOLE 3-FLUORO-2-METHOXYBENZALDEHYDE

3-Fluoro-2-hydroxybenzaldehyde Suppliers

Global( 292)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Changzhou Carman Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 3-Fluoro-2-hydroxybenzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	3-Fluoro-2-hydroxybenzaldehyde 394-50-3	US $0.00-0.00 / KG	10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2024-02-15	3-Fluorosalicylaldehyde 394-50-3	US $430.00 / g	1g	97	500 Kg	R&D Scientific Inc.
2022-02-22	3-Fluoro-2-hydroxybenzaldehyde 394-50-3	US $0.00 / KG	1KG	97.1%	100 tons	Honest Joy Holdings Limited

3-Fluoro-2-hydroxybenzaldehyde
394-50-3
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

3-Fluorosalicylaldehyde
394-50-3
US $430.00 / g
97
R&D Scientific Inc.

3-Fluoro-2-hydroxybenzaldehyde
394-50-3
US $0.00 / KG
97.1%
Honest Joy Holdings Limited

3-Fluoro-2-hydroxybenzaldehyde Spectrum

3-Fluoro-2-hydroxybenzaldehyde(394-50-3)MS 3-Fluoro-2-hydroxybenzaldehyde(394-50-3)¹HNMR 3-Fluoro-2-hydroxybenzaldehyde(394-50-3)¹⁹FNMR 3-Fluoro-2-hydroxybenzaldehyde(394-50-3)IR1

394-50-3(3-Fluoro-2-hydroxybenzaldehyde)Related Search:

3-Fluoro-2-hydroxybenzaldehyde 3,4-Difluoro-2-methoxybenzoic acid 3,5-DIFLUORO-2-METHOXYBENZOIC ACID 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE

3-FLUORO-2-METHOXYBENZALDEHYDE 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE 3-FLUORO-2-METHOXYBENZOIC ACID 3-FLUORO-2-HYDROXYBENZOIC ACID 3,5-Difluoro-4-hydroxybenzaldehyde

5-Fluorosalicylaldehyde 4-FLUORO-2-HYDROXYBENZALDEHYDE,4-FLUOROSALICYLALDEHYDE (4-FLUORO-2-HYDROXYBENZALDEHYDE) 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE 2-FLUORO-6-HYDROXYBENZALDEHYDE,2-Fluoro-6-hydroxybenzaldehyde 98% 3-FLUORO-4-HYDROXYBENZALDEHYDE

2-FLUORO-4-HYDROXYBENZALDEHYDE 2-FLUORO-5-HYDROXYBENZALDEHYDE Salicylaldehyde

1of4

3-FLUOROSALICYLALDEHYDE 3-FLUORO-2-HYDROXYBENZALDEHYDE 3-Fluoro-2-Hydroxybenzaldehyde 3-Fluoro Salicylaldehyde 3-Fluorosalicylaldehyde,98% 1-Fluoro-6-formylphenol 3-Fluoro-2-hydroxybenzaldehyde ,99% 2-Hydroxy-3-fluorobenzaldehyde 3-fluorosalicyldadehyde 3-Fluorosalicylaldehyde ,99% 3-Fluoro-2-hydroxybe 3-Fluorosalicylaldehyde, 2-Fluoro-6-formylphenol 3-Fluorosalicylaldehyde> Benzaldehyde, 3-fluoro-2-hydroxy- 5-Fluoro-3-nitroacetophenone 3-Fluoro-2-hydroxybenzaldehyde1 394-50-3 94-50-3 FC6H32OHCHO ALDEHYDE Carbonyl Compounds Building Blocks Aldehydes C7 Organic Building Blocks Aldehydes C7 Carbonyl Compounds Aryl Hydroxy Organohalides Benzenes Fluorobenzene Aromatic Aldehydes & Derivatives (substituted)