3-Maleimidopropionic acid
- CAS No.
- 7423-55-4
- Chemical Name:
- 3-Maleimidopropionic acid
- Synonyms
- 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)PROPANOIC ACID;BMPA;3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID;MPA-OH;3-Maleimidopropionic;3-(2,5-Dioxopyrrol-1-yl)propanoic acid;AKOS BC-0729;Mal-(CH2)2-COOH;MALEOYL-BETA-ALA-OH;RARECHEM AL CD 0912
- CBNumber:
- CB1371466
- Molecular Formula:
- C7H7NO4
- Molecular Weight:
- 169.13
- MDL Number:
- MFCD00043030
- MOL File:
- 7423-55-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Maleoyl-β-alanine 97% | 394815 | 250mg | $246 |
| N-Maleoyl-β-alanine 97% | 394815 | 1g | $519 |
| 3-Maleimidopropionic Acid >97.0%(GC) | M1962 | 1g | $80 |
| 3-Maleimidopropionic Acid >97.0%(GC) | M1962 | 5g | $273 |
| 3-Maleimidopropionic Acid | M2132-60 | 1g | $446 |
| More product size | |||
| Melting point | 103-106 °C (lit.) |
|---|---|
| Boiling point | 382.5±25.0 °C(Predicted) |
| Density | 1.473±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.18±0.10(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in methanol, dimethyl formamide, alcohol and dimethyl sulfoxide. Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1528952 |
| InChI | InChI=1S/C7H7NO4/c9-5-1-2-6(10)8(5)4-3-7(11)12/h1-2H,3-4H2,(H,11,12) |
| InChIKey | IUTPJBLLJJNPAJ-UHFFFAOYSA-N |
| SMILES | N1(CCC(O)=O)C(=O)C=CC1=O |
| CAS DataBase Reference | 7423-55-4(CAS DataBase Reference) |
| FDA UNII | Q5C4V9T6GU |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29252900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Maleimidopropionic acid price More Price(113)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 394815 | N-Maleoyl-β-alanine 97% | 7423-55-4 | 250mg | $246 | 2026-04-30 | Buy |
| Sigma-Aldrich | 394815 | N-Maleoyl-β-alanine 97% | 7423-55-4 | 1g | $519 | 2026-04-30 | Buy |
| TCI Chemical | M1962 | 3-Maleimidopropionic Acid >97.0%(GC) | 7423-55-4 | 1g | $80 | 2026-04-30 | Buy |
| TCI Chemical | M1962 | 3-Maleimidopropionic Acid >97.0%(GC) | 7423-55-4 | 5g | $273 | 2026-04-30 | Buy |
| Usbiological | M2132-60 | 3-Maleimidopropionic Acid | 7423-55-4 | 1g | $446 | 2026-06-03 | Buy |
3-Maleimidopropionic acid Chemical Properties,Uses,Production
Description
3-Maleimidopropionic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical Properties
White to Pale Yellow Solid
Uses
3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.
Application
3-Maleimidopropionic acid (3MP) is a molecule that can be used for the treatment of cancer. 3MP has been shown to inhibit the growth of tumor cells and induce apoptosis. It also inhibits the production of reactive oxygen species, which are produced by cancer cells as a result of chemotherapy. 3MP has potent inhibitory activity against bacterial organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens and antiviral properties against HIV infection. This molecule can also be used in conjunction with monoclonal antibodies or other immunotherapy techniques to improve their efficacy.
General Description
N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.
Synthesis
An acetic acid solution of maleic anhydride (5.00 g in 50 mL) was added dropwise to an acetic acid solution of β-alanine (4.54 g in 50 mL). The mixture was stirred at room temperature. After 3 h, AcOH (70 mL ) was added and the temperature was raised to 115 °C under stirred overnight. After 1 hour, an orange oil was obtained. The solvent excess was removed under reduced pressure and the product was washed with toluene (3 × 30 mL). The product was then purified by flash chromatography using a silica column (DCM/ethylacetate 9:1) to obtain the white solid 3-Maleimidopropionic acid.
References
[1] International Journal of Molecular Sciences, 2017, vol. 18, # 9,
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9955 - 9968
[3] Journal of Controlled Release, 2015, vol. 220, p. 660 - 670
[4] Chemistry - A European Journal, 2015, vol. 21, # 38, p. 13186 - 13190
[5] Journal of the American Chemical Society, 2013, vol. 135, # 11, p. 4333 - 4363
3-Maleimidopropionic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 491 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5216 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3004 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
View Lastest Price from 3-Maleimidopropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-13 | 3-Maleimidopropionic acid
7423-55-4
|
10g | 98%min HPLC | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-03 | 3-Maleimidopropionic acid
7423-55-4
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 3-Maleimidopropionic acid
7423-55-4
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 3-Maleimidopropionic acid
7423-55-4
- $0.00
- 98%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Maleimidopropionic acid
7423-55-4
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Maleimidopropionic acid
7423-55-4
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
