7-(TRIFLUOROMETHYL)-4-QUINOLINOL
- CAS No.
- 322-97-4
- Chemical Name:
- 7-(TRIFLUOROMETHYL)-4-QUINOLINOL
- Synonyms
- BUTTPARK 21\09-46;7-(trifluorophenyl)quinolin-4-ol;7-(TRIFLUOROMETHYL)-4-QUINOLINOL;4-Quinolinol, 7-(trifluoromethyl)-;7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE;7-(Trifluoromethyl)-4-quinolinol,97%;7-(TRIFLUOROMETHYL)-4-QUINOLINOL 97%;7-(trifluoromethyl)-1H-quinolin-4-one;4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE;7-(TrifluoroMethyl)-4-hydroxy quinoline
- CBNumber:
- CB1380866
- Molecular Formula:
- C10H6F3NO
- Molecular Weight:
- 213.16
- MDL Number:
- MFCD00006779
- MOL File:
- 322-97-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Hydroxy-7-(trifluoromethyl)quinoline 96% | 184217 | 10g | $153 |
| 7-(Trifluoromethyl)-4-quinolinol | T797070 | 100mg | $75 |
| 4-Hydroxy-7-(trifluoromethyl)quinoline 98% | 4H56-3-74 | 1g | $75 |
| 7-(Trifluoromethyl)-4-quinolinol 98% | 005411 | 5g | $94 |
| 7-(Trifluoromethyl)-4-quinolinol 98% | 005411 | 1g | $29 |
| More product size | |||
| Melting point | 266-269 °C(lit.) |
|---|---|
| Boiling point | 311.9±37.0 °C(Predicted) |
| Density | 1.3581 (estimate) |
| storage temp. | 2-8°C |
| pka | 3.79±0.40(Predicted) |
| form | Powder |
| color | Light grayish to beige |
| InChIKey | OWPLFJSQLPTCHS-UHFFFAOYSA-N |
| CAS DataBase Reference | 322-97-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29334990 | |||||||||
| NFPA 704 |
|
7-(TRIFLUOROMETHYL)-4-QUINOLINOL price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 184217 | 4-Hydroxy-7-(trifluoromethyl)quinoline 96% | 322-97-4 | 10g | $153 | 2023-06-20 | Buy |
| TRC | T797070 | 7-(Trifluoromethyl)-4-quinolinol | 322-97-4 | 100mg | $75 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-3-74 | 4-Hydroxy-7-(trifluoromethyl)quinoline 98% | 322-97-4 | 1g | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 005411 | 7-(Trifluoromethyl)-4-quinolinol 98% | 322-97-4 | 5g | $94 | 2021-12-16 | Buy |
| Matrix Scientific | 005411 | 7-(Trifluoromethyl)-4-quinolinol 98% | 322-97-4 | 1g | $29 | 2021-12-16 | Buy |
7-(TRIFLUOROMETHYL)-4-QUINOLINOL Chemical Properties,Uses,Production
Chemical Properties
Light greyish-beige powder
Uses
4-Hydroxy-7-(trifluoromethyl)quinoline was used in the synthesis of 4[[7-(trifluoromethyl)quinolin-4-yl]oxy]pthalonitrile.
Definition
ChEBI: 7-(trifluoromethyl)-1H-quinolin-4-one is a member of quinolines.
Synthesis
391-02-6
322-97-4
General procedure for the synthesis of 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid from ethyl 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate: Compound I-D (5 g) and potassium hydroxide (3 equiv.) were dissolved in 60 ml of a solvent mixture of water and ethylene glycol (1:1) in a sealed XP-500 Plus container. The reaction was microwave heated at 200°C and 220-240 psi pressure for 30 minutes using a MARS 5 microwave system. After completion of the reaction, the mixture was cooled to room temperature and poured into 100 ml of water. The solution was acidified to pH ≈ 6 with 2N hydrochloric acid, subsequently saturated with sodium chloride and extracted with tetrahydrofuran (3 x 200 ml). The organic layers were combined, washed with brine and concentrated to give compounds I-E in over 80% yield.
References
[1] Patent: WO2005/63739, 2005, A1. Location in patent: Page/Page column 45-46
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 371,373
7-(TRIFLUOROMETHYL)-4-QUINOLINOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20342 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
View Lastest Price from 7-(TRIFLUOROMETHYL)-4-QUINOLINOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-03-09 | 7-(TRIFLUOROMETHYL)-4-QUINOLINOL
322-97-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-25 | 7-(TRIFLUOROMETHYL)-4-QUINOLINOL
322-97-4
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 7-(TRIFLUOROMETHYL)-4-QUINOLINOL
322-97-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 7-(TRIFLUOROMETHYL)-4-QUINOLINOL
322-97-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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