1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine
![1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine Structure](CAS/20180529/GIF/792927-06-1.gif)
- CAS No.
- 792927-06-1
- Chemical Name:
- 1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine
- Synonyms
- 1'-bipiperidine;TASIN-1, 10 mM in DMSO;inhibit,TASIN-1,TASIN 1,Inhibitor,TASIN1;1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4;1'-[(4-methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine;1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine;1,4'-Bipiperidine, 1'-[(4-methoxyphenyl)sulfonyl]-4-methyl-
- CBNumber:
- CB13863098
- Molecular Formula:
- C18H28N2O3S
- Molecular Weight:
- 352.49
- MDL Number:
- MFCD03992224
- MOL File:
- 792927-06-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21155 | TASIN-1 ≥98% | 792927-06-1 | 500μg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 21155 | TASIN-1 ≥98% | 792927-06-1 | 1mg | $255 | 2026-04-30 | Buy |
| ApexBio Technology | A8738 | TASIN-1 | 792927-06-1 | 5mg | $105 | 2026-05-06 | Buy |
| ApexBio Technology | A8738 | TASIN-1 | 792927-06-1 | 25mg | $380 | 2026-05-06 | Buy |
| Ambeed | A1209305 | TASIN-1 95% | 792927-06-1 | 5mg | $58 | 2026-06-05 | Buy |
1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine Chemical Properties, Uses, Production
Uses
TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC[1].
Biological Activity
tasin-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (apc) [1].adenomatous polyposis coli (apc) is a multifunctional tumor suppressor gene that is mutated in more than 80% of colon tumors. apc plays an important role in the negative regulation of canonical wnt signaling pathway through proteasomal degradation of b-catenin. apc is involved in cell cycle control, migration, differentiation, and apoptosis [1].tasin-1 is a selective inhibitor of mutant apc. in two authentic human crc cell lines hct116 (wt apc) and dld1 (truncated apc1417), tasin-1 exhibited potent and selective toxicity toward dld1 cells with ic50 value of 70 nm but not toward hct116 cells (ic50 >50 μm). tasin-1 also reduced the endogenous cholesterol biosynthesis rate. tasin-1 exerted its killing effects primarily by depleting cholesterol through inhibition of emopamil-binding protein (ebp) activity. however, knockdown of truncated apc (>90%) expression desensitized dld1 cells to tasin-1, suggesting that apc is required for tasin-1’s cytotoxicity [1].in nude mice with established dld1 and ht29 tumors, intraperitoneal injection of tasin-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. tasin-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved parp1. however, tasin-1 did not inhibit tumor growth in hct116 (wt apc) xenografts. in a genetically engineered crc mouse model, tasin-1 significantly reduced tumor formation in the colons of cpc;apc mice [1].1.lu zhang, panayotis c. theodoropoulos, ugur eskiocak, et al. selective targeting of mutant adenomatous polyposis coli (apc) in colorectal cancer. science translational medicine 19 oct 2016: vol. 8, issue 361, pp. 361ra140.
References
[1] Zhang L, et al. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140. DOI:10.1126/scitranslmed.aaf8127
1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4183 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
