Isopropyl unoprostone
- CAS No.
- 120373-24-2
- Chemical Name:
- Isopropyl unoprostone
- Synonyms
- UF-021;Rescul;RESCULA;Unii-5m161S5o5p;ISOPROPY UNOPROSTONE;isopropyl unoprostone;UNOPROSTONE ISOPROPYL ESTER;Isopropyl unoprostone USP/EP/BP;Uroprostaglandin isopropyl ester;13,14-dihydro-15-keto-20-ethyl-pgf
- CBNumber:
- CB1392171
- Molecular Formula:
- C25H44O5
- Molecular Weight:
- 424.61
- MDL Number:
- MFCD00886951
- MOL File:
- 120373-24-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 546.3±45.0 °C(Predicted) |
|---|---|
| Density | 1.019±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 14.79±0.70(Predicted) |
| color | Clear Colourless |
| CAS DataBase Reference | 120373-24-2(CAS DataBase Reference) |
| FDA UNII | 5M161S5O5P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P270-P271-P280-P301+P312-P330-P303+P361+P353-P304+P340-P305+P351+P338-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
Isopropyl unoprostone price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16681 | Unoprostone isopropyl ester ≥95% | 120373-24-2 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 16681 | Unoprostone isopropyl ester ≥95% | 120373-24-2 | 5mg | $283 | 2026-04-30 | Buy |
| Cayman Chemical | 16681 | Unoprostone isopropyl ester ≥95% | 120373-24-2 | 10mg | $502 | 2026-04-30 | Buy |
| Cayman Chemical | 16681 | Unoprostone isopropyl ester ≥95% | 120373-24-2 | 50mg | $2039 | 2026-04-30 | Buy |
| TRC | TRC-U800050-1MG | Unoprostone Isopropyl Ester | 120373-24-2 | 1mg | $279 | 2026-06-03 | Buy |
Isopropyl unoprostone Chemical Properties, Uses, Production
Description
Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF2α, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.
Description
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.
Chemical Properties
Clear Colourless Oil
Originator
Ueno (Japan)
Uses
Antiglaucoma; used in treatment of ocular hypertension.
Uses
Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.
Definition
ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.
brand name
Rescuia
Hazard
A poison.
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] T TANIGUCHI. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits.[J]. Journal of Ocular Pharmacology and Therapeutics, 1996, 12 4: 489-498. DOI: 10.1089/jop.1996.12.489
Isopropyl unoprostone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemvon Biotechnology Co., Ltd | 021-50790412 | info@chemvon.com | China | 371 | 57 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 762 | 50 | |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Wuhan Senwayer Century Chemical Co.,Ltd | 027-86652399 | sales@senwayer.com | China | 266 | 55 |
View Latest Price from Isopropyl unoprostone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Unoprostone isopropyl
120373-24-2
|
$198.00-1650.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-06-25 | Isopropyl unoprostone
120373-24-2
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Isopropyl unoprostone
120373-24-2
|
$7.00 | 1KG | 99% | 200KG | Career Henan Chemical Co |
-
- Unoprostone isopropyl
120373-24-2
- $198.00-1650.00
- TargetMol Chemicals Inc.
-
- Isopropyl unoprostone
120373-24-2
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Isopropyl unoprostone
120373-24-2
- $7.00
- 99%
- Career Henan Chemical Co
120373-24-2 (Isopropyl unoprostone) Related Search:
1of4
