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(+)-DIOP

(+)-DIOP structure

CAS No.: 37002-48-5

Chemical Name:: (+)-DIOP

Synonyms: (S,S)-DIOP;(((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphane);(S)-DIOP;(+)-DIOP;(+)-DIOP;idene-2,3-butanedioL;phosphino)-2,3-O-isopropyL;(2S,3S)-(+)-1,4-Bis(diphenyL;(4S,5S)-(+)-4,5-BIS(DIPHENYLPHOSPHINOMET;4,5-bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxalan

CBNumber:: CB1393749

Molecular Formula:: C31H32O2P2

Molecular Weight:: 498.54

MDL Number:: MFCD00009760

MOL File:: 37002-48-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:35:26

Product description	Number	Pack Size	Price
(2S,3S)-(+)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol >95.0%(GC)(T)	B1112	1g	$122
(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP 99.5%	15-2960	250mg	$60
(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP 99.5%	15-2960	1g	$145
(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP	15-2960	250mg	$57
(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP	15-2960	1g	$139

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(+)-DIOP Properties

Melting point	86-88 °C(lit.)
alpha	+26° (c 2.0, CHCl3)
Boiling point	590.3±25.0 °C(Predicted)
storage temp.	Store below +30°C.
form	Powder
color	White
optical activity	28.6°(C=0.01g/ml DCM)
Water Solubility	Sparingly soluble in water at 25°C 2.1E-5 g/L.
Sensitive	Air Sensitive
BRN	1630280
InChIKey	VCHDBLPQYJAQSQ-LOYHVIPDSA-N
SMILES	P(C1C=CC=CC=1)(C1C=CC=CC=1)C[C@H]1OC(C)(C)O[C@@H]1CP(C1C=CC=CC=1)C1C=CC=CC=1 \|&1:14,20,r\|
CAS DataBase Reference	37002-48-5
FDA UNII	5P52K0IJ7T
UNSPSC Code	12352128

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

10-23

HS Code

29319090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

(+)-DIOP price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B1112	(2S,3S)-(+)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol >95.0%(GC)(T)	37002-48-5	1g	$122	2021-12-16	Buy
Strem Chemicals	15-2960	(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP 99.5%	37002-48-5	250mg	$60	2026-04-30	Buy
Strem Chemicals	15-2960	(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP 99.5%	37002-48-5	1g	$145	2026-04-30	Buy
Strem Chemicals	15-2960	(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP	37002-48-5	250mg	$57	2024-03-01	Buy
Strem Chemicals	15-2960	(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, 99.5% (S,S)-DIOP	37002-48-5	1g	$139	2024-03-01	Buy

Product number	Packaging	Price	Buy
B1112	1g	$122	Buy
15-2960	250mg	$60	Buy
15-2960	1g	$145	Buy
15-2960	250mg	$57	Buy
15-2960	1g	$139	Buy

(+)-DIOP Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

It is employed as a ligand for the in situ preparation of chiral hydrogenation catalysts. It also finds it application for the in situ preparation of chiral hydrogenation catalysts, ligand for Rh(I)-catalyzed asymmetric hydrogenation of enamides, 1,4-disilylation of α,β-unsaturated ketones, Heck reaction of alkenyl iodides, and hydroformylation of olefins.

Purification Methods

It has been recrystallised from *C6H6/pet ether. After 2 recrystallisations from EtOH, it was pure by TLC on silica gel using Me2CO/hexane as solvent. [Kagan & Dang J Am Chem Soc 94 6429 1972.] Lanthanide shift reagents See in “Aliphatic Compounds”, Chapter 4, europium (III) acetate above and Eu(tmc)3 and Eu(tfc)3 below.

(+)-DIOP Preparation Products And Raw materials

Raw materials

L(+)-Diethyl L-tartrate p-Toluenesulfonic acid Triethyl orthoformate Sodium Methanesulfonyl chloride

Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Dichloromethane L(+)-Tartaric acid

Triphenylphosphine Petroleum ether Lithium

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Preparation Products

(+)-DIOP Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3587	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49969	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Aladdin Scientific	58

View Lastest Price from (+)-DIOP manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	(+)-DIOP 37002-48-5		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-12	(2S,3S)-(+)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol 37002-48-5	$1.00	1KG	99%	20 Tons	Shaanxi Dideu Medichem Co. Ltd
2019-07-10	(+)-DIOP 37002-48-5	$3.00	1KG	99%	100kg	Career Henan Chemical Co

(+)-DIOP
37002-48-5
99%
Hebei Chuanghai Biotechnology Co., Ltd

(2S,3S)-(+)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol
37002-48-5
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

(+)-DIOP
37002-48-5
$3.00
99%
Career Henan Chemical Co

(+)-DIOP Spectrum

(+)-DIOP(37002-48-5)MS (+)-DIOP(37002-48-5)¹HNMR (+)-DIOP(37002-48-5)IR1 (+)-DIOP(37002-48-5)IR2 (+)-DIOP(37002-48-5)Raman

37002-48-5((+)-DIOP)Related Search:

Amino-2-propanol (-)-DIOP 4-METHYL-1,3-DIOXOLANE 2-METHYL-1,3-DIOXOLANE ETHYLDIPHENYLPHOSPHINE

2,2-DIMETHYL-1,3-DIOXOLANE 1,4-Bis(diphenylphosphino)butane 1,3-Dioxolane 2,2,4-TRIMETHYL-1,3-DIOXOLANE 2,4-DIMETHYL, 1,3-DIOXALONE

(+)-DIOP 2,2-Diethoxypropane DIPHENYL-N-PROPYLPHOSPHINE Diphenylphosphine Diisooctyl phthalate

BUTYLDIPHENYLPHOSPHINE 1,4-BIS(DIMETHYLPHOSPHINO)BUTANE (-)-MOD-DIOP

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(4S,5S)-(+)-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane (+)-DIOP (2S,3S)-(+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosp (S)-DIOP (S,S)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 1,1'-[[(4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)]bis[1,1-diphenyl-Phosphine (4S,5S)-(+)-4,5-Bis(diphenylphosphinoMethyl)-2,2-diMethyl-1,3-dioxolane,(S,S)-DIOP. (+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane (S,S)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane [(4S,5S)-5-(diphenylphosphanylmethyl)-2,2- dimethyl-1,3-dioxolan-4-yl]methyl-diphenylphosphane (4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2- dimethyl-1,3-dioxolane for synthesis (+)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE (+)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-D-THREITOL 4,5-bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxalan (+)-DIOP, (S,S)-DIOP, (4S,5S)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, (4S-trans)-[(2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)]bis(diphenylphosphine) (4S-TRANS)-[(2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DIYL)BIS(METHYLENE)]BIS(DIPHENYLPHOSPHINE) (4S,5S)-(+)-4,5-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE (4S,5S)-4,5-BIS(DIPHENYLPHOSPHINO-METHYL)-2,2-DIMETHYL-1,3-DIOXOLANE (4S 5S)-(+)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE (4S,5S)-(+)-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE (+)-DIOP (2S,3S)-(+)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL (2S,3S)-(+)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE (4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane,99.5%(S,S)-DIOP Phosphine, (4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diylbis(methylene)bisdiphenyl- (+)-DIOP, (S,S)-DIOP, (+)-1,4-Bis(diphenylphosphino)-1,4-dideoxy-2,3-O-isopropylidene-D-threitol, (4S,5S)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane, (4S-trans)-[(2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)]bis(diphenylphosphine) (4S,5S)-2,2-Dimethyl-4,5-bis(diphenylphosphinomethyl)-1,3-dioxolane (4α,5β)-2,2-Dimethyl-4,5-bis(diphenylphosphinomethyl)-1,3-dioxolane [(4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)bis(diphenylphosphine) [(4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl]bismethylenebis(diphenylphosphine) [[(4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)]bis(diphenylphosphine) (4S,5S)-(+)-4,5-Bis(diphenylphosphinoMethyl)-2,2-diMethyl-1,3-dioxolane,99% (S,S)-DIOP (+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane,98% (2S,3S)-(+)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol > (2S,3S)-(+)-1,4-Bis(diphenylphosphino)-2,3-O-isopropylidene-2,3-butanediol[(+)-DIOP] (4S,5S)-(+)-4,5-BIS(DIPHENYLPHOSPHINOMET Phosphine, 1,1'-[[(4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)]bis[1,1-diphenyl- (+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino) (2S,3S)-(+)-1,4-Bis(diphenyL idene-2,3-butanedioL phosphino)-2,3-O-isopropyL (+)-2,2-dimethyl-4,5-((diphenylphosphino)dimethyl)dioxolane (+)-2,3-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis(Diphenylphosphino)Butane (S,S)-DIOP/(4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane (4S,5S)-(+)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane,98% (S,S)-DIOP 1,1'-[[(4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl]bis(methylene)]bis[1,1-diphenylphosphine (+)-DIOP (((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphane) (S,S)-DIOP 37002-48-5 Phosphine Ligands Dioxanes & Dioxolanes Asymmetric Synthesis Dioxolanes Chiral Catalysts, Ligands, and Reagents Privileged Ligands organophosphine ligand Phosphine Ligands Asymmetric Synthesis