GO 6976
- CAS No.
- 136194-77-9
- Chemical Name:
- GO 6976
- Synonyms
- G6976;GO 6976;GOE 6976;PD406976;Aids044729;Aids-044729;Go6976 Go-6976;Go6976 (PD40697);GO 6976 USP/EP/BP;InSolution? G? 6976
- CBNumber:
- CB1396876
- Molecular Formula:
- C24H18N4O
- Molecular Weight:
- 378.43
- MDL Number:
- MFCD00236434
- MOL File:
- 136194-77-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Gö6976-CAS136194-77-9-Calbiochem G?6976,CAS136194-77-9,isacell-permeable,reversible,andATP-competitivei | 365250 | 500μg | $270 |
| G? 6976 | 365250 | 1mg | $350 |
| Gö 6976 ≥98% | 13310 | 500μg | $54 |
| Gö 6976 ≥98% | 13310 | 1mg | $102 |
| Gö 6976 ≥98% | 13310 | 5mg | $238 |
| Melting point | >221°C (dec.) |
|---|---|
| Boiling point | 652.3±55.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly) |
| form | Off-white solid |
| pka | 14.39±0.20(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
| InChIKey | VWVYILCFSYNJHF-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(C=CC=C2)C2=C1C1N(CCC#N)C3=C(C=1C1CNC(=O)C=12)C=CC=C3 |
| FDA UNII | B9IQO7JZ16 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | WGK 1 |
| HS Code | 2933998090 |
| Storage Class | 10 - Combustible liquids |
GO 6976 price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 365250 | Gö6976-CAS136194-77-9-Calbiochem G?6976,CAS136194-77-9,isacell-permeable,reversible,andATP-competitivei | 136194-77-9 | 500μg | $270 | 2026-04-30 | Buy |
| Sigma-Aldrich | 365250 | G? 6976 | 136194-77-9 | 1mg | $350 | 2026-04-30 | Buy |
| Cayman Chemical | 13310 | Gö 6976 ≥98% | 136194-77-9 | 500μg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 13310 | Gö 6976 ≥98% | 136194-77-9 | 1mg | $102 | 2026-04-30 | Buy |
| Cayman Chemical | 13310 | Gö 6976 ≥98% | 136194-77-9 | 5mg | $238 | 2026-04-30 | Buy |
GO 6976 Chemical Properties,Uses,Production
Uses
Go 6976 is a potent FLT3 inihibtor which is been shown to initiate cytotoxicity involving acute leukemia. Also known as a PKC inhibitor, which results into apoptosis and tumor destruction. Cancer therapeutic agent.
Definition
ChEBI: Goe 6976 is an organic heterohexacyclic compound and an indolocarbazole. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor.
Biological Activity
Potent protein kinase C (PKC) inhibitor (IC 50 = 7.9 nM). In vitro, discriminates between Ca 2+ -dependent and -independent isoforms of PKC; selectively inhibits PKC α and PKC β 1 (IC 50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKC δ , - ε , or - ζ (IC 50 > 3 μ M). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC 50 values are 5, 30, 130 and 370 nM respectively).
storage
-20°C (desiccate)
Background
Gö6976 is an ATP-competitive PKC inhibitor specific for Ca2+-dependent PKCα and PKCβ1 isozymes. It is also a potent inhibitor of PKD. Researchers have demonstrated that Gö6976 blocks JNK activation and inhibits PKCα-mediated, TPA-stimulated phosphorylation of CREB at Ser133. Gö6976 is also an effective inhibitor of the tyrosine kinases Jak2 and FLT3, as well as TrkA and TrkB.
References
[1]. gschwendt, m., et al., inhibition of protein kinase c mu by various inhibitors. differentiation from protein kinase c isoenzymes. febs lett, 1996. 392(2): p. 77-80.
[2]. qatsha, k.a., et al., go 6976, a selective inhibitor of protein kinase c, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. proc natl acad sci u s a, 1993. 90(10): p. 4674-8.
[3]. joksovic, p.m., et al., mechanisms of inhibition of t-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase c pathway. mol pharmacol, 2010. 77(1): p. 87-94.
[4]. taube, e., et al., a novel treatment strategy for egfr mutant nsclc with t790m-mediated acquired resistance. int j cancer, 2012. 131(4): p. 970-9.
[5]. yoshida, a., et al., go6976, a flt3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and mcl-1. biochem pharmacol, 2014. 90(1): p. 16-24.
GO 6976 Preparation Products And Raw materials
Raw materials
Preparation Products
GO 6976 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20792 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from GO 6976 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-02 | Go6976
136194-77-9
|
$64.00-263.00 | 98.13% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | G? 6976
136194-77-9
|
$1.00 | 1g | 95-99% | 1ton | Career Henan Chemical Co | |
 |
2020-01-13 | GO 6976
136194-77-9
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
136194-77-9(GO 6976)Related Search:
1of4
