Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3'-Hydroxyacetophenone

3'-Hydroxyacetophenone

3'-Hydroxyacetophenone Structure
3'-Hydroxyacetophenone structure
CAS No.
121-71-1
Chemical Name:
3'-Hydroxyacetophenone
Synonyms
1-(3-Hydroxyphenyl)ethan-1-one;3-HYDROXYACETOPHENONE;Ethanone, 1-(3-hydroxyphenyl)-;3-ACETYLPHENOL;3-ACETOPHENOL;3-Hydroxyacetophenon;M-HYDROXYACETOPHENONE;META-HYDROXYACETOPHENONE;3-HAP;m-Acetylphenol
CBNumber:
CB1407158
Molecular Formula:
C8H8O2
Molecular Weight:
136.15
MDL Number:
MFCD00002298
MOL File:
121-71-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:33:58
Request For Quotation

3'-Hydroxyacetophenone Properties

Melting point 90-95 °C(lit.)
Boiling point 296 °C(lit.)
Density 1.1 g/mL at 25 °C(lit.)
vapor pressure 0.022Pa at 25℃
refractive index 1,534
Flash point 296°C
storage temp. Inert atmosphere,Room Temperature
solubility 22g/l
form Crystalline Powder
pka 9.19(at 25℃)
color Beige-brown
Water Solubility Soluble in alcohol. Insoluble in water.
BRN 2040676
InChI 1S/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3
InChIKey LUJMEECXHPYQOF-UHFFFAOYSA-N
SMILES CC(=O)c1cccc(O)c1
LogP 1.144 at 25℃
CAS DataBase Reference 121-71-1(CAS DataBase Reference)
FDA UNII UV3GO1D90J
NIST Chemistry Reference Ethanone, 1-(3-hydroxyphenyl)-(121-71-1)
EPA Substance Registry System Ethanone, 1-(3-hydroxyphenyl)- (121-71-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  22-24/25-37/39-26-36
WGK Germany  3
Hazard Note  Harmful/Irritant
TSCA  TSCA listed
HS Code  29143990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
REACH Registrations Active
NFPA 704
1
2 0

3'-Hydroxyacetophenone price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 328103 3′-Hydroxyacetophenone ≥99% 121-71-1 5g $28.5 2026-04-30 Buy
Sigma-Aldrich 328103 3′-Hydroxyacetophenone ≥99% 121-71-1 25g $45.6 2026-04-30 Buy
TCI Chemical A0104 3'-Hydroxyacetophenone >98.0%(GC)(T) 121-71-1 25g $32 2026-04-30 Buy
TCI Chemical A0104 3'-Hydroxyacetophenone >98.0%(GC)(T) 121-71-1 500g $271 2026-04-30 Buy
Biosynth FH67676 3'-Hydroxyacetophenone 121-71-1 0.5kg $150 2026-06-04 Buy
Product number Packaging Price Buy
328103 5g $28.5 Buy
328103 25g $45.6 Buy
A0104 25g $32 Buy
A0104 500g $271 Buy
FH67676 0.5kg $150 Buy

3'-Hydroxyacetophenone Chemical Properties, Uses, Production

Description

3’-Hydroxyacetophenone is a chemical compound and it is a component of castoreum, the exudate from the castor sacs of the mature beaver. It is used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.

Chemical Properties

beige-brown crystalline powder

Uses

3’Hydroxyacetophenone is a chemical reagent used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.

Uses

Useful in the preparation of chalcones, flavonoids, and phenylephrine. It is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.

Uses

3Hydroxyacetophenone is used in the preparation of chalcones and flavonoids, which finds application as an anti-tuberculosis agent and antileishmanial chaocones. It is also involved in the preparation of phenylephrine. Further, it is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.

Preparation

Preparation by diazotization of 3-aminoacetophenone, followed by hydrolysis of the obtained diazonium salt (78–82%).

General Description

3′-Hydroxyacetophenone is an hydroxy-substituted alkyl phenyl ketone.

Flammability and Explosibility

Non flammable

Synthesis

3'-IODOACETOPHENONE

14452-30-3

3'-Hydroxyacetophenone

121-71-1

General procedure for the synthesis of 3-hydroxyacetophenone from 3-iodoacetophenone: 3-iodoacetophenone (1.0 mmol), CuCl (13.4 mg, 0.1 mmol), KOH (336 mg, 6.0 mmol), ethylene glycol (12 μL, 0.2 mmol), and a solvent mixture of DMSO/HO were sequentially added to the test tube fitted with a magnetic stirrer ( 1.0 mL/0.5 mL). The reaction mixture was placed in a preheated 120 °C oil bath under argon protection and stirred for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted by partitioning with 5% HCl aqueous solution and ethyl acetate. The organic phase was washed sequentially with water and saturated saline, dried over anhydrous MgSO and concentrated under reduced pressure to remove the solvent. The crude product was further purified by column chromatography (eluent: EtOAc/hexane) to afford the target product 3-hydroxyacetophenone.

References

[1] Journal of the American Chemical Society, 2016, vol. 138, # 41, p. 13493 - 13496
[2] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 12, p. 2833 - 2840
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[4] Synlett, 2016, vol. 27, # 12, p. 1814 - 1819

3'-Hydroxyacetophenone synthesis

99-03-6
121-71-1
Synthesis of 3'-Hydroxyacetophenone from 3-Aminoacetophenone

3'-Hydroxyacetophenone Preparation Products And Raw materials

Raw materials

3-Aminoacetophenone 1-[3-(methoxymethoxy)phenyl]ethanone 1-[3-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone 3'-Iodoacetophenone Acetophenone
3-Methoxyacetophenone 3-Hydroxyphenylacetylene 3-Ethoxyacetophenone Acetic acid Dimethyl sulfoxide

1of2

Preparation Products

Aplpha-bromo-m-benzoyloxyacetophenone 4-Hydroxyphenylacetamide 1-(3-hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethan-1-one 1-(5-hydroxy-2-nitrophenyl)ethanone 2-Bromo-3′-hydroxyacetophenone
3-ACETAMIDOPHENOL Ethanone, 1-[3-(2,2,2-trifluoroethoxy)phenyl]- Ethanone, 1-[3-(2-propyn-1-yloxy)phenyl]- 2-Butenoic acid, 4-(3-hydroxy-2-nitrophenyl)-4-oxo- 1-(3-Hydroxy-4-iodophenyl)ethanone
8-Methoxy-3,4-diMethyl-1H-isochroMen-1-one

1of3

3'-Hydroxyacetophenone Suppliers

Global Suppliers ( 774)
Supplier Tel Email Country ProdList Advantage
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd 18072846723 marketing002@witofly.com China 1634 58
Changzhou Luowan Biological Technology Co., Ltd. 13646143635;18069669245 617837247@qq.com China 142 58
ShangHai Siyan Biological Technology Co., Ltd. 021-50908862，442785678，326799392 18721037013 siyansales@126.com China 9612 58
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375818 15064153060 1329217348@qq.com China 1448 58
Guangzhou Greensyn Co., Ltd. 00000 luojunjian@greensyn.com China 278 58
Huaian Jiamu Biotechnology Co., Ltd. 0517-83187139 18205232085 cai@jiamu-bio.com China 3000 58
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
Tianjin Zhongxin Chemtech Co., Ltd. 022-66880623 sales@tjzxchem.com China 612 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd 58
Changzhou Luowan Biological Technology Co., Ltd. 58
ShangHai Siyan Biological Technology Co., Ltd. 58
Jinan Dexinjia Bio&Tech Co., Ltd 58
Guangzhou Greensyn Co., Ltd. 58
Huaian Jiamu Biotechnology Co., Ltd. 58
Shanghai Qiao Chemical Science Co., Ltd 65
Tianjin Zhongxin Chemtech Co., Ltd. 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

Related articles

View Latest Price from 3'-Hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3'-Hydroxyacetophenone pictures 2026-10-14 3'-Hydroxyacetophenone
121-71-1
 0.99 RongNa Biotechnology Co.,Ltd
3'-Hydroxyacetophenone pictures 2026-09-02 3'-Hydroxyacetophenone
121-71-1
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
3-ACETYLPHENOL pictures 2026-09-02 3-ACETYLPHENOL
121-71-1
 $3.00-10.00 1kg 99% Henan Fengda Chemical Co., Ltd

3'-Hydroxyacetophenone Spectrum

3'-Hydroxyacetophenone(121-71-1)MS3'-Hydroxyacetophenone(121-71-1)1HNMR3'-Hydroxyacetophenone(121-71-1)13CNMR3'-Hydroxyacetophenone(121-71-1)IR13'-Hydroxyacetophenone(121-71-1)IR23'-Hydroxyacetophenone(121-71-1)Raman

121-71-1 (3'-Hydroxyacetophenone) Related Search:

4'-Chloroacetophenone 3-Aminoacetophenone 4-Nitroacetophenone 4'-Methoxyacetophenone Acetophenone
4'-Bromoacetophenone 3,5-Dihydroxyacetophenone 3-Nitroacetophenone 6-Chloromethylmorphanthridine Eptifibatide non cyclic impurity
7-Bromo Epinastine Benzamide, N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-2-(hydroxymethyl)- L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→7)-disulfide (9CI) Methanone, (2-aminophenyl)phenyl-, hydrazone, (Z)- N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide
L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, bimol. cyclic (1→1'),(6→6')-bis(disulfide) Cyclo(L-Pro-L-Trp-) Eptifibatide impurity 3/Deamidated Eptifibatide Impurity/(3R,11S,17S,20S,25aS)-20-((1H-indol-3-yl)Methyl)-17-(carboxymethyl)-11-(4-guanidinobutyl)-1,9,12,15,18,21-hexaoxodocosahydro-1H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-3-carbo

1of4

m-Acetylphenol m-Hydroxyacetophenonel 3'-Hydroxyacetophenone 3-Acetylphenol m-Acetylphenol 3'-HYDROXYACETOPHENONE, 99+% 3-Hydroxyacetophenon 3-Hydroxyacetophenone98% 1-(3-Hydroxyphenyl)ethan-1-one, 3-Acetylphenol 3-Acetophenol 3-Acetylphenol 3-Hydroxyphenyl Methyl Ketone 1-(3-hydro Etilefrine Impurity E (3-Hydroxy Acetopheone) 3-HAP Etilefrine EP Impurity E Rivastigmine Impurity 4 3'-Hydroxyacetophenone≥ 99% (Assay) Etilefrine Impurity E m-HYDROXYACETOPHENONE pract 3-HYDROXYPHENYL METHYL KETONE 1-(3-HYDROXY-PHENYL)-ETHANONE AKOS BBS-00003275 M-HYDROXYACETOPHENONE 1-(3-hydroxyphenyl)-ethanon Acetophenone, 3'-hydroxy- 1,3-Dihydroxy-2,4-dinitrosonaphthalene 2,4-Dinitrosonaphthalene-1,3-diol Methyl 3-hydroxyphenyl ketone LABOTEST-BB LT01658526 M-ACETOPHENOL m-Hydroxyacetoph 3'-Hydroxyacetopheno M-hydroxyacetone 3'-Hydroxyacetophenone > 1-(3-Hydroxyphenyl)ethanone (3-Hydr Etilefrine EP Impurity E (3-HydroxyAcetophenone) 4-methyl-3-hydroxy acetophenone m-Hydroxyacetophenone pure, 98% m-HYDROXY ACETOPHENONE For Synthesis Etilefrine Hydrochloride Impurity E Etilefrine Hydrochloride EP Impurity E 3' -Hydroxyacetophenone Etilefrine Impurity 5 (Etilefrine EP Impurity E) 5-Hydroxy Acetophenone 3-Hydroxyacetophenone (3HAP) 3'-Hydroxyacetophenone 13C6]-2'-Bromo-5'-fluoroacetophenone m-Hydroxy Acetophenone 96% For Synthesis 1-(3-Hydroxyphenyl)ethanone (3-Hydroxyacetophenone) 3′-Hydroxyacetophenone, CAS 121-71-1 3-Hydroxyacetophenon (3-HAP) Faropenem Impurity: 3’-Hydroxyacetophenone 3-ACETOPHENOL 1-(3-Hydroxyphenyl)ethan-1-one 3-ACETYLPHENOL 3-HYDROXYACETOPHENONE Ethanone, 1-(3-hydroxyphenyl)- META-HYDROXYACETOPHENONE 121-71-1 211-71-1