3'-Hydroxyacetophenone
- CAS No.
- 121-71-1
- Chemical Name:
- 3'-Hydroxyacetophenone
- Synonyms
- 3-HYDROXYACETOPHENONE;1-(3-Hydroxyphenyl)ethan-1-one;Ethanone, 1-(3-hydroxyphenyl)-;3-ACETYLPHENOL;3-Hydroxyacetophenon;M-HYDROXYACETOPHENONE;3-HAP;3-ACETOPHENOL;m-Acetylphenol;META-HYDROXYACETOPHENONE
- CBNumber:
- CB1407158
- Molecular Formula:
- C8H8O2
- Molecular Weight:
- 136.15
- MDL Number:
- MFCD00002298
- MOL File:
- 121-71-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3′-Hydroxyacetophenone ≥99% | 328103 | 5g | $26.8 |
| 3′-Hydroxyacetophenone ≥99% | 328103 | 25g | $42.9 |
| 3'-Hydroxyacetophenone >98.0%(GC)(T) | A0104 | 25g | $32 |
| 3'-Hydroxyacetophenone >98.0%(GC)(T) | A0104 | 500g | $271 |
| 3′-Hydroxyacetophenone 97% | H18801 | 25g | $50.25 |
| More product size | |||
| Melting point | 90-95 °C(lit.) |
|---|---|
| Boiling point | 296 °C(lit.) |
| Density | 1.1 g/mL at 25 °C(lit.) |
| vapor pressure | 0.022Pa at 25℃ |
| refractive index | 1,534 |
| Flash point | 296°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 22g/l |
| form | Crystalline Powder |
| pka | 9.19(at 25℃) |
| color | Beige-brown |
| Water Solubility | Soluble in alcohol. Insoluble in water. |
| BRN | 2040676 |
| InChIKey | LUJMEECXHPYQOF-UHFFFAOYSA-N |
| LogP | 1.144 at 25℃ |
| CAS DataBase Reference | 121-71-1(CAS DataBase Reference) |
| FDA UNII | UV3GO1D90J |
| NIST Chemistry Reference | Ethanone, 1-(3-hydroxyphenyl)-(121-71-1) |
| EPA Substance Registry System | Ethanone, 1-(3-hydroxyphenyl)- (121-71-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful/Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29143990 | |||||||||
| NFPA 704 |
|
3'-Hydroxyacetophenone price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 328103 | 3′-Hydroxyacetophenone ≥99% | 121-71-1 | 5g | $26.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | 328103 | 3′-Hydroxyacetophenone ≥99% | 121-71-1 | 25g | $42.9 | 2025-07-31 | Buy |
| TCI Chemical | A0104 | 3'-Hydroxyacetophenone >98.0%(GC)(T) | 121-71-1 | 25g | $32 | 2025-07-31 | Buy |
| TCI Chemical | A0104 | 3'-Hydroxyacetophenone >98.0%(GC)(T) | 121-71-1 | 500g | $271 | 2025-07-31 | Buy |
| Sigma-Aldrich | H18801 | 3′-Hydroxyacetophenone 97% | 121-71-1 | 25g | $50.25 | 2025-07-31 | Buy |
3'-Hydroxyacetophenone Chemical Properties,Uses,Production
Description
3’-Hydroxyacetophenone is a chemical compound and it is a component of castoreum, the exudate from the castor sacs of the mature beaver. It is used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.
Chemical Properties
beige-brown crystalline powder
Uses
3’Hydroxyacetophenone is a chemical reagent used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.
Uses
Useful in the preparation of chalcones, flavonoids, and phenylephrine. It is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.
Uses
3?Hydroxyacetophenone is used in the preparation of chalcones and flavonoids, which finds application as an anti-tuberculosis agent and antileishmanial chaocones. It is also involved in the preparation of phenylephrine. Further, it is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.
Preparation
Preparation by diazotization of 3-aminoacetophenone, followed by hydrolysis of the obtained diazonium salt (78–82%).
General Description
3′-Hydroxyacetophenone is an hydroxy-substituted alkyl phenyl ketone.
Flammability and Explosibility
Non flammable
Synthesis
14452-30-3
121-71-1
General procedure for the synthesis of 3-hydroxyacetophenone from 3-iodoacetophenone: 3-iodoacetophenone (1.0 mmol), CuCl? (13.4 mg, 0.1 mmol), KOH (336 mg, 6.0 mmol), ethylene glycol (12 μL, 0.2 mmol), and a solvent mixture of DMSO/H?O were sequentially added to the test tube fitted with a magnetic stirrer ( 1.0 mL/0.5 mL). The reaction mixture was placed in a preheated 120 °C oil bath under argon protection and stirred for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted by partitioning with 5% HCl aqueous solution and ethyl acetate. The organic phase was washed sequentially with water and saturated saline, dried over anhydrous MgSO? and concentrated under reduced pressure to remove the solvent. The crude product was further purified by column chromatography (eluent: EtOAc/hexane) to afford the target product 3-hydroxyacetophenone.
References
[1] Journal of the American Chemical Society, 2016, vol. 138, # 41, p. 13493 - 13496
[2] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 12, p. 2833 - 2840
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[5] Synlett, 2016, vol. 27, # 12, p. 1814 - 1819
3'-Hydroxyacetophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Jianxin Biotechnology Co., LTD | +undefined-86-1906231316-9 +undefined86-19062313169 | liyingjian1997@gmail.com | China | 712 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8757 | 58 |
| Nanjing Deda New Material Technology Co., Ltd | +8613223293093 | bella@njdeda.com | China | 80 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5244 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20130 | 58 |
| Hebei Yiduo Import and Export Co., Ltd. | joycedemei1505@outlook.com | China | 215 | 58 | |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13588 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21604 | 55 |
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View Lastest Price from 3'-Hydroxyacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-01-05 | 3'-Hydroxyacetophenone
121-71-1
|
US $10.00 / KG | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-01-05 | 3'-Hydroxyacetophenone
121-71-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-09-25 | 3'-Hydroxyacetophenone
121-71-1
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 3'-Hydroxyacetophenone
121-71-1
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3'-Hydroxyacetophenone
121-71-1
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 3'-Hydroxyacetophenone
121-71-1
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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