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4-Hydroxybenzoic acid

4-Hydroxybenzoic acid Structure
4-Hydroxybenzoic acid structure
CAS No.
99-96-7
Chemical Name:
4-Hydroxybenzoic acid
Synonyms
P-HYDROXYBENZOIC ACID;PARA HYDROXY BENZOIC ACID;PHBA;4-hydroxy;p-Salicylic acid;4-Carboxyphenol;p-hydroxybenzoic;4-hydroxy-benzoicaci;P-OXYBENZOIC ACID;p-Carboxyphenol
CBNumber:
CB1412080
Molecular Formula:
C7H6O3
Molecular Weight:
138.12
MDL Number:
MFCD00002547
MOL File:
99-96-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:34:54
Product description Number Pack Size Price
4-Hydroxybenzoic acid phyproof® Reference Substance PHL83051 100 mg $247
4-Hydroxybenzoic acid for synthesis 8.21814 5G $26.1
4-Hydroxybenzoic acid for synthesis 8.21814 250G $33.7
4-Hydroxybenzoic acid for synthesis 8.21814 1KG $100
4-Hydroxybenzoic acid for synthesis 8.21814 50KG $2460
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4-Hydroxybenzoic acid Properties

Melting point 213-217 °C (lit.)
Boiling point 213.5°C (rough estimate)
Density 1,46 g/cm3
bulk density 600kg/m3
vapor pressure 0Pa at 20℃
refractive index 1.4600 (estimate)
FEMA 3986 | 4-HYDROXYBENZOIC ACID
FLAVIS Number 08.040 | 4-Hydroxybenzoic acid
Flash point 199 °C
storage temp. Store below +30°C.
solubility methanol: soluble5%, clear to slightly hazy, colorless to faintly yellow
form Crystalline Powder
pka 4.48(at 19℃)
color White to ivory
PH 3.3 (1g/l, H2O, 20℃)
Odor at 100.00 %. phenolic nutty
Odor Type phenolic
biological source synthetic
Water Solubility 5 g/L (20 ºC)
Merck 14,4812
JECFA Number 957
BRN 970950
Henry's Law Constant 1.4×106 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
Cosmetics Ingredients Functions PRESERVATIVE
FRAGRANCE
Cosmetic Ingredient Review (CIR) 4-Hydroxybenzoic acid (99-96-7)
InChI 1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)
InChIKey FJKROLUGYXJWQN-UHFFFAOYSA-N
SMILES OC(=O)c1ccc(O)cc1
LogP 0.878 at 22℃
CAS DataBase Reference 99-96-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 4-HYDROXYBENZOIC ACID
EWG's Food Scores 3
FDA UNII JG8Z55Y12H
NIST Chemistry Reference Benzoic acid, 4-hydroxy-(99-96-7)
EPA Substance Registry System p-Hydroxybenzoic acid (99-96-7)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H318-H335
Precautionary statements  P261-P271-P280-P304+P340+P312-P305+P351+P338-P403+P233
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  26-37/39-36
WGK Germany  1
RTECS  DH1925000
Autoignition Temperature >250 °C
TSCA  TSCA listed
HS Code  29182930
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1
STOT SE 3
Hazardous Substances Data 99-96-7(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
REACH Registrations Active
NFPA 704
0
2 0

4-Hydroxybenzoic acid price More Price(102)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL83051 4-Hydroxybenzoic acid phyproof® Reference Substance 99-96-7 100 mg $247 2026-04-30 Buy
Sigma-Aldrich 8.21814 4-Hydroxybenzoic acid for synthesis 99-96-7 5G $26.1 2026-04-30 Buy
Sigma-Aldrich 8.21814 4-Hydroxybenzoic acid for synthesis 99-96-7 250G $33.7 2026-04-30 Buy
Sigma-Aldrich 8.21814 4-Hydroxybenzoic acid for synthesis 99-96-7 1KG $100 2026-04-30 Buy
Sigma-Aldrich 8.21814 4-Hydroxybenzoic acid for synthesis 99-96-7 50KG $2460 2026-04-30 Buy
Product number Packaging Price Buy
PHL83051 100 mg $247 Buy
8.21814 5G $26.1 Buy
8.21814 250G $33.7 Buy
8.21814 1KG $100 Buy
8.21814 50KG $2460 Buy

4-Hydroxybenzoic acid Chemical Properties,Uses,Production

Description

4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid or PHBA, is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohol and acetone. It is isomeric with salicylic acid (2-hydroxybenzoic acid), a forerunner to aspirin, and 3-hydroxybenzoic acid. The esters of 4-hydroxybenzoic acid, also called parabens, are widely used as preservatives in cosmetics and some ophthalmic solutions.

Chemical Properties

4-Hydroxybenzoic acid is an odorless white crystalline astringent powder. In pure form, it imparts a sweetish taste at first, which quickly becomes acrid and disagreeable

Occurrence

4-Hydroxybenzoic acid is a phenolic acid that has been found in a variety of fruit peels and leaves. It can be found naturally in coconut. It is one of the main catechins metabolites found in humans after consumption of green tea infusions. It is also found in wine, in vanilla, in Macrotyloma uniflorum (horse gram), carob and in Phyllanthus acidus (Otaheite gooseberry).

Uses

4-Hydroxybenzoic acid is used as an intermediate for dyes, antiseptics and active pharmaceutical ingredients. It is also used as a food preservative, corrosion inhibitor, anti-oxidant and an emulsifier. It reacts with 6-hydroxynaphthalene-2-carboxylic acid to prepare aromatic polyester called Vectran fiber. It acts as a precursor to prepare p-hydroxyphenylbenzoate, p-acetoxybenzoyl chloride and 4,4'-dihydroxybenzophenone. Further, it is used in paint additives, coating additives, processing aids, electrical and electronic products. In addition to this, it acts as a preservative in cosmetics and some ophthalmic solutions.

Uses

In organic. syntheses; intermediate for dyes, fungicides.

Uses

p-Hydroxybenzoic acid is of significant commercial importance. The most familiar application is the use of several of its esters as preservatives, known as parabens. Also of interest is the use in liquid crystal polymer applications.

Definition

ChEBI: 4-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring. It has a role as a plant metabolite and an algal metabolite. It is a conjugate acid of a 4-hydroxybenzoate.

Preparation

Prepared from p-bromophenol or p-hydroxybenzaldehyde, or from saponification of methyl salicylate, a major component of oil of wintergreen.
In 1947, H. Gilman and C. E. Arntzen at Iowa State College (Ames) reported the synthesis of 4-HBA from 4-hydroxybenzaldehyde. Several other preparation methods were developed since then. Today it is produced commercially via the Kolbe–Schmitt reaction, which originated in the mid-1800s. Potassium phenoxide and CO2 are heated under pressure; the reaction mixture is then acidified to obtain the product 4-Hydroxybenzoic acid. (Oddly, if the sodium salt is used, the product is 2-hydroxybenzoic acid, or salicylic acid.)
Org. Synth. 1934, 14, 48
DOI: 10.15227/orgsyn.014.0048

Application

4-Hydroxybenzoic acid can be used as a starting material to synthesize organic intermediates such as 4-acetoxybenzoic acid and 4-hydroxy-3,5-diiodobenzoic acid.
4-Hydroxybenzoic acid is used as an intermediate for dyes, antiseptics and active pharmaceutical ingredients. It is also used as a food preservative, corrosion inhibitor, anti-oxidant and an emulsifier. It reacts with 6-hydroxynaphthalene-2-carboxylic acid to prepare aromatic polyester called Vectran fiber. It acts as a precursor to prepare p-hydroxyphenylbenzoate, p-acetoxybenzoyl chloride and 4,4′-dihydroxybenzophenone. Further, it is used in paint additives, coating additives, processing aids, electrical and electronic products. In addition to this, it acts as a preservative in cosmetics and some ophthalmic solutions.

Aroma threshold values

Detection at 5 ppm (water)

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 174, 1984 DOI: 10.1021/ja00313a035
The Journal of Organic Chemistry, 29, p. 3459, 1964 DOI: 10.1021/jo01035a003

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Hydroxybenzoic acid belongs to the class of aromatic acids, which may be used as a preservative in cosmetics, pharmaceuticals and as a synthetic flavoring agent in food products.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise the hydroxyacid from water. [Beilstein 10 IV 345.]

4-Hydroxybenzoic acid synthesis

1000389-71-8
99-96-7
Synthesis of 4-Hydroxybenzoic acid from Benzenamine, 4-(tri-1H-pyrazol-1-ylmethyl)-

4-Hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Saccharin Potassium hydroxide Phenol Dipotassium rabdosiin Rabdosiin Potassium hydroxide solution
Tosyl chloride potassium phenolate Potassium sulfate Methyl 4-bromobenzoate 4-Iodobenzoic acid
4-(3-BUTENYLOXY)BENZOIC ACID 4-BENZYLOXYBENZOIC ACID

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Preparation Products

Propylparaben Methylparaben 4-N-BUTOXYBENZOIC ACID Isobutylparaben Bromoxynil
Ethylparaben Butylparaben Isopropylparaben 2-Bromobenzonitrile 4-Cyanophenol
4-Methoxybenzoic acid CYANOPHOS Heptyl 4-hydroxybenzoate Sorbic acid

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4-Hydroxybenzoic acid Suppliers

Global( 994)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5228 58
Wuhan Han Sheng New Material Technology Co.，Ltd 		+8617798174412 admin01@hsnm.com.cn China 2097 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 283 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Anhuyan (Hainan) Biotechnology Co., LTD 		+8618163349544 mollylucking@foxmail.com China 3000 58
JINING XINHE CHEMICAL CO., LTD 		+8615318402391 sales@xinhepharma.com China 809 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Wuhan Han Sheng New Material Technology Co.，Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Anhuyan (Hainan) Biotechnology Co., LTD 		58
JINING XINHE CHEMICAL CO., LTD 		58
Capot Chemical Co.,Ltd. 		60

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Related Qustion

Ask a question
Q:What is 4-hydroxybenzoic acid (4-HBA)'s uses? Is it harmful?Zora - Apr 28，2026
A: 4-hydroxybenzoic acid(4-HBA)is a monohydroxybenzoic acid in which a benzoic acid carries a hydroxy substituent at C-4 of the benzene ring, which is a conjugate acid of 4-hydroxybenzoate. It has a strong antioxidant capacity had been reported in soybeans. 4-hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions. It has a low oral toxicity.

View Lastest Price from 4-Hydroxybenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
p-Salicylic acid pictures 2026-06-06 p-Salicylic acid
99-96-7
 0.99 RongNa Biotechnology Co.,Ltd
4-Hydroxybenzoic acid pictures 2026-05-28 4-Hydroxybenzoic acid
99-96-7
 $9.10 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
4-Hydroxybenzoic acid pictures 2026-05-22 4-Hydroxybenzoic acid
99-96-7
 1G/KG 99% 1000000000KG Anhuyan (Hainan) Biotechnology Co., LTD

4-Hydroxybenzoic acid Spectrum

4-Hydroxybenzoic acid(99-96-7)MS4-Hydroxybenzoic acid(99-96-7)1HNMR4-Hydroxybenzoic acid(99-96-7)13CNMR4-Hydroxybenzoic acid(99-96-7)IR14-Hydroxybenzoic acid(99-96-7)IR24-Hydroxybenzoic acid(99-96-7)Raman4-Hydroxybenzoic acid(99-96-7)ESR

99-96-7(4-Hydroxybenzoic acid)Related Search:

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acidop-idrossibenzoico Benzoic acid, p-hydroxy- benzoicacid,4-hydroxy Benzoicacid,4-hydroxy- Hydroxybenzoic acid, para Kyselina 4-hydroxybenzoova kyselina4-hydroxybenzoova p-hydroxybenzoic RARECHEM AL BO 0112 FEMA 3986 HYDROXYBENZOIC ACID, 4- AKOS BBS-00003776 ACETYLSALISYLIC ACID IMP A ACETYLSALICYLIC ACID IMPURITY A 4-Hydroxybenzoic acid Vetec(TM) reagent grade, 99% 4-Hydroxybenzoic acid Solution, 100ppm Acetylsalicylic Acid IMpurity A (Aspirin IMpurity A) Salicylic Acid Related CoMpound A 4-Hydroxybenzoic acid ReagentPlus(R), >=99% 4-Hydroxybenzoic acid ReagentPlus(R), 99% p-Hydroxybenzoic acid, Standard for GC,>=99.5%(GC) 4-HYDROXYBENZOIC ACID 4-hydroxybenzenecarboxylic acid PARA HYDROXY BENZONIC ACID PARAHYDROXY BENZOIC ACID (POLYMER GRADE OF 99 4-HYDROXYBENZOIC ACID, 99+% P-HYDROXYBENZOIC ACID 99+% 4-Hydroxybenzoic acid, 99.5% 4-Hydroxybenzoic Acid-carboxyl-13C P-HYDROXYBENZOICACID,REAGENT PARA-HYDROXYBENZOATE PARA-CARBOXYPHENOL 4-HYDROXYBENZOIC ACID / P-HYDROXYBENZOIC ACID Aspirin EP IMpurity A Aspirin IMpurity A Aspirin Impurity 1 P-hydroxybenzoic acid (acetylsalicylic acid impurity A/aspirin impurity A) p-hydroxy-benzoicaci p-oxybenzoesaure p-salicylicacid 4-Hydroyxbenzoic acid NSC 4961 Paraben-acid 4-Hydroxybenzoic acid, 99+% 100GR LR-68 Hydroxybenzenecarboxylic acid Salicylic Acid Related Compound A (100 mg) (4-hydroxybenzoic acid) Acetylsalicylic Acid EP Impurity A Acetylsalicylic Acid Impurity 1（Acetylsalicylic Acid EP Impurity A） Para Hydroxy Benzoic Acid (PHBA) Salicylic Acid EP Impurityuriy A p-Hydroxybenzoic acid(PHBA) Cefazolin Impurity 3 (1H-Tetrazole-1-Acetic Acid) PHBA 4-Hydroxybenzoic acid 4-Hydroxybenzoic acid (Paraben)@100 μg/mL in AcCN 4-HydroxybenzoicAcid> Salicylic Acid EP Impurity A 4-HYDROXYBENZOIC ACID FOR SYNTHESIS