N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- CAS No.
- 70375-43-8
- Chemical Name:
- N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- Synonyms
- SCH-202676;SCH202676 HBr;AURORA KA-7903;SCH 202676 HBr;SCH-202676 HBr;SCH 202676 HYDROBROMIDE;SCH 202676 HBr,SCH202676 HBr;SCH-202676, GPCR allosteric modulator;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR
- CBNumber:
- CB1420216
- Molecular Formula:
- C15H13N3S
- Molecular Weight:
- 267.35
- MDL Number:
- MFCD06671539
- MOL File:
- 70375-43-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SCH202676hydrobromide ≥99%(HPLC) | 1400 | 10 | $181 |
| SCH202676hydrobromide ≥99%(HPLC) | 1400 | 50 | $749 |
| SCH-202676 | S200038 | 10mg | $95 |
| SCH 202676 hydrobromide | 256627 | 10mg | $438 |
| SCH-202676 95.00% | INB0000135 | 10MG | $250.95 |
| More product size | |||
| Melting point | 240.0-240.8 °C(lit.) |
|---|---|
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 40 mg/mL |
| form | Yellow solid. |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1400 | SCH202676hydrobromide ≥99%(HPLC) | 70375-43-8 | 10 | $181 | 2021-12-16 | Buy |
| Tocris | 1400 | SCH202676hydrobromide ≥99%(HPLC) | 70375-43-8 | 50 | $749 | 2021-12-16 | Buy |
| TRC | S200038 | SCH-202676 | 70375-43-8 | 10mg | $95 | 2021-12-16 | Buy |
| Usbiological | 256627 | SCH 202676 hydrobromide | 70375-43-8 | 10mg | $438 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000135 | SCH-202676 95.00% | 70375-43-8 | 10MG | $250.95 | 2021-12-16 | Buy |
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties,Uses,Production
Description
SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3
Uses
SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.
Biological Activity
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M).
IC 50
Adenosine A3 receptor
References
[1] A B FAWZI. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.[J]. Molecular Pharmacology, 2001, 59 1: 30-37. DOI:10.1124/mol.59.1.30
[2] ANNA M LEWANDOWICZ Jarmo T L Jouko Vepsäläinen. The “allosteric modulator” SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.[J]. British Journal of Pharmacology, 2006, 147 4: 422-429. DOI:10.1038/sj.bjp.0706624
[3] ANIKÓ GÖBLYÖS. Synthesis and Biological Evaluation of a New Series of 2,3,5-Substituted [1,2,4]-Thiadiazoles as Modulators of Adenosine A1 Receptors and Their Molecular Mechanism of Action[J]. Journal of Medicinal Chemistry, 2005, 48 4: 1145-1151. DOI:10.1021/jm049337s
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19957 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24960 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
View Lastest Price from N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-21 | SCH-202676 HBr
70375-43-8
|
US $1980.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
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- SCH-202676 HBr
70375-43-8
- US $1980.00-1520.00 / mg
- TargetMol Chemicals Inc.
