Carbadox
- CAS No.
- 6804-07-5
- Chemical Name:
- Carbadox
- Synonyms
- CBX;M31;MOD1;gs6244;CARBADO;Mecadox;p25beta;CARBADOX;fortigro;getroxel
- CBNumber:
- CB1425347
- Molecular Formula:
- C11H10N4O4
- Molecular Weight:
- 262.22
- MDL Number:
- MFCD00057293
- MOL File:
- 6804-07-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 239-240°C |
|---|---|
| Boiling point | 405.47°C (rough estimate) |
| Density | 1.3602 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| Flash point | 18°(64°F) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly, Sonicated) |
| form | powder |
| pka | 10.51±0.46(Predicted) |
| color | Yellow to Dark Yellow |
| Water Solubility | Soluble in 1N NaOH (50 mg/ml), and water (partly). |
| Henry's Law Constant | 2.2×1017 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Light Sensitive |
| InChI | 1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+ |
| InChIKey | OVGGLBAWFMIPPY-WUXMJOGZSA-N |
| SMILES | COC(=O)N\N=C\c1cn(=O)c2ccccc2n1=O |
| CAS DataBase Reference | 6804-07-5 |
| FDA 21 CFR | 556.100; 558.115; 558.4 |
| EWG's Food Scores | 4 |
| FDA UNII | M2X04R2E2Y |
| EPA Substance Registry System | Hydrazinecarboxylic acid, 2-[(1,4-dioxido-2-quinoxalinyl)methylene]-, methyl ester (6804-07-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H302-H350 | |||||||||
| Precautionary statements | P201-P210-P240-P280-P405-P501a | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 45-11-22 | |||||||||
| Safety Statements | 53-45 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FE2779000 | |||||||||
| HazardClass | 4.1 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Carc. 1B Flam. Sol. 1 |
|||||||||
| Hazardous Substances Data | 6804-07-5(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Carbadox price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24903 | Carbadox ≥98% | 6804-07-5 | 10g | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24903 | Carbadox ≥98% | 6804-07-5 | 25g | $60 | 2024-03-01 | Buy |
| TRC | TRC-C275825-5G | Carbadox (Technical Grade) | 6804-07-5 | 5g | $179 | 2026-06-03 | Buy |
| TRC | TRC-C275825-1G | Carbadox (Technical Grade) | 6804-07-5 | 1g | $105 | 2026-06-03 | Buy |
| TRC | TRC-C275825-100MG | Carbadox (Technical Grade) | 6804-07-5 | 100mg | $65 | 2026-06-03 | Buy |
Carbadox Chemical Properties, Uses, Production
Chemical Properties
Yellow Crystalline Solid
Originator
Carbadox,Agrimex
Uses
Carbadox has been used to suppress aldosterone production, to study the spread of shiga toxin-producing Escherichia coli (STEC) strains, and to compare different antimicrobial activities. Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency. It inhibits bacteria by intercalation and induction of mutations in bacterial genome.
Definition
ChEBI: Carbadox is a quinoxaline derivative.
Manufacturing Process
A solution of methylcarbazate (48.0 mg) in methanol (250 ml) is added all at
once at room temperature to a well stirred solution of 2-formylquinoxaline-
1,4-dioxide (100 g) in methanol (2.5 liters). Two drops of concentrated
hydrochloric acid are added. The mixture is stirred for 3 hours then filtered to remove the yellow crystalline product. The crystals of (2-
quinoxalinylmethylene)hydrazinecarboxylic acid methyl ester are washed with
methanol then air dried; M.P. 234.5-236°C (dec.). Yield=121.8 g. The product
is purified by refluxing in chloroform for 2 hours, followed by filtration and air
drying; M.P. 239.5-240°C (dec.).
The ultraviolet absorption spectrum (water) exhibits maxima at 236, 251,
303, 366 and 373 nm with extinction coefficients of 11,000, 10,900, 36,400,
16,100 and 16,200, respectively.
brand name
Mecadox (Pfizer).
Therapeutic Function
Antibacterial
Biochem/physiol Actions
Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency. It inhibits bacteria by intercalation and induction of mutations in bacterial genome.
Safety Profile
Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Nox.
Carbadox Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| TianJin Alta Scientific Co., Ltd. | 022-65378550-8551 | contact@altascientific.com | China | 2772 | 58 |
