2-Chloro-6-methyl-3-pyridinecarbonitrile
- CAS No.
- 28900-10-9
- Chemical Name:
- 2-Chloro-6-methyl-3-pyridinecarbonitrile
- Synonyms
- AKOS BBS-00008244;BUTTPARK 153\57-09;IFLAB-BB F3250-0678;TIMTEC-BB SBB006618;2-Chloro-3-Cyano-6-Picoline;2-CHLORO-6-METHYLNICOTINONITRILE;2-chloro-3-cyano-6-methypyridine;2-CHLORO-3-CYANO-6-METHYLPYRIDINE;2-Chloro-6-methyl-3-cyano-pyridine;2-chloro-6-methylnicotinonitrile 99%
- CBNumber:
- CB1450563
- Molecular Formula:
- C7H5ClN2
- Molecular Weight:
- 152.58
- MDL Number:
- MFCD00082767
- MOL File:
- 28900-10-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-6-methyl-3-pyridinecarbonitrile | C369780 | 25g | $350 |
| 2-Chloro-6-methyl-3-pyridinecarbonitrile | C369780 | 2g | $80 |
| 2-Chloro-6-methylnicotinonitrile 98% | OR29740 | 5g | $87 |
| 2-Chloro-3-cyano-6-methylpyridine | FC55195 | 5G | $90 |
| 2-Chloro-3-cyano-6-methylpyridine | V0838 | 5g | $47 |
| More product size | |||
| Melting point | 114-116 °C (lit.) |
|---|---|
| Boiling point | 140-145 °C (lit.) |
| Density | 1.2763 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | -1.21±0.10(Predicted) |
| form | Solid |
| color | Pale Yellow |
| BRN | 120414 |
| InChI | InChI=1S/C7H5ClN2/c1-5-2-3-6(4-9)7(8)10-5/h2-3H,1H3 |
| InChIKey | YSBNBAYNISAUIT-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(C)=CC=C1C#N |
| CAS DataBase Reference | 28900-10-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chloro-3-cyano-6-methylpyridine(28900-10-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335-H318 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-37/39-36/37/39-22 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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2-Chloro-6-methyl-3-pyridinecarbonitrile price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C369780 | 2-Chloro-6-methyl-3-pyridinecarbonitrile | 28900-10-9 | 25g | $350 | 2021-12-16 | Buy |
| TRC | C369780 | 2-Chloro-6-methyl-3-pyridinecarbonitrile | 28900-10-9 | 2g | $80 | 2021-12-16 | Buy |
| Apolloscientific | OR29740 | 2-Chloro-6-methylnicotinonitrile 98% | 28900-10-9 | 5g | $87 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC55195 | 2-Chloro-3-cyano-6-methylpyridine | 28900-10-9 | 5G | $90 | 2021-12-16 | Buy |
| AK Scientific | V0838 | 2-Chloro-3-cyano-6-methylpyridine | 28900-10-9 | 5g | $47 | 2021-12-16 | Buy |
2-Chloro-6-methyl-3-pyridinecarbonitrile Chemical Properties,Uses,Production
Uses
2-Chloro-6-methyl-3-pyridinecarbonitrile, is a building block used for the synthesis of various biologically active compounds. It can be used for the preparation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as new potent anticancer agents.
Chemical Properties
light yellow to brown cryst. flakes or needles
Uses
2-Chloro-6-methyl-3-pyridinecarbonitrile, is a building block used for the synthesis of various biologically active compounds. It can be used for the preparation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as new potent anticancer agents.
Uses
2-Chloro-6-methyl-3-pyridinecarbonitrile (2-chloro-6-methylnicotinonitrile) may be used in the preparation of methyl-2-nitropyridinecarboxamides.
Synthesis
4241-27-4
28900-10-9
Step 1: 6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (45.0 g, 335 mmol) was added to phosphorochloridic acid (652 g, 4250 mmol) and the reaction was stirred at 130°C for 2 hours. After the reaction was completed, the reaction solution was concentrated and the resulting residue was dissolved in dichloromethane and the pH was adjusted to 8 by slowly adding 4 M aqueous sodium hydroxide.The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 2-chloro-6-methylnicotinonitrile (51.0 g, 99% yield).1H NMR (400 MHz, CDCl3) δ 2.65 (s, 3H), 7.24 (d, J = 8.0 Hz, 1H), 7.89 (d, J = 8.0 Hz, 1H).
References
[1] Patent: US2017/145005, 2017, A1. Location in patent: Paragraph 0149; 0150; 0151; 0152
[2] Heterocycles, 1995, vol. 41, # 6, p. 1307 - 1318
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 2206 - 2210
[4] Polish Journal of Chemistry, 1982, vol. 56, # 2, p. 419 - 423
[5] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2014, vol. 69, # 5, p. 509 - 518
2-Chloro-6-methyl-3-pyridinecarbonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21597 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Synbest Biotech(Hangzhou) Co., Ltd | 86-571-88737065 | sales@synbestech.com | CHINA | 170 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 2-Chloro-6-methyl-3-pyridinecarbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Chloro-6-methyl-3-pyridinecarbonitrile
28900-10-9
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | 2-Chloro-6-methyl-3-pyridinecarbonitrile
28900-10-9
|
US $1.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- 2-Chloro-6-methyl-3-pyridinecarbonitrile
28900-10-9
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloro-6-methyl-3-pyridinecarbonitrile
28900-10-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
