4-CHLORO-6-NITROQUINAZOLINE
- CAS No.
- 19815-16-8
- Chemical Name:
- 4-CHLORO-6-NITROQUINAZOLINE
- Synonyms
- 4-Chloro-6-nitro-quizoline;4-choro-6-nitroquinazoline;4-CHLORO-6-NITROQUINAZOLINE;Quinazoline,4-chloro-6-nitro-
- CBNumber:
- CB1450967
- Molecular Formula:
- C8H4ClN3O2
- Molecular Weight:
- 209.59
- MDL Number:
- MFCD00464269
- MOL File:
- 19815-16-8.mol
| Melting point | 128 °C |
|---|---|
| Boiling point | 380.0±22.0 °C(Predicted) |
| Density | 1.566±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Dichloromethane |
| form | Solid |
| pka | 0.14±0.50(Predicted) |
| color | Brown |
| CAS DataBase Reference | 19815-16-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-CHLORO-6-NITROQUINAZOLINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C374785 | 4-Chloro-6-nitroquinazoline | 19815-16-8 | 250mg | $1095 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0036751 | 4-CHLORO-6-NITROQUINAZOLINE 95.00% | 19815-16-8 | 5G | $1114.58 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20158 | 4-Chloro-6-nitroquinazoline | 19815-16-8 | 250mg | $1530 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0036751 | 4-CHLORO-6-NITROQUINAZOLINE 95.00% | 19815-16-8 | 2.5G | $932.6 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H54-5-07 | 4-Chloro-6-nitroquinazoline 98% | 19815-16-8 | 250mg | $50 | 2021-12-16 | Buy |
4-CHLORO-6-NITROQUINAZOLINE Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of anticancer agents and enzyme inhibitors.
Synthesis
6943-17-5
19815-16-8
Step 1: Synthesis of 4-chloro-6-nitroquinazoline To a solution of toluene (200 mL) containing 6-nitroquinazolin-4-ol (9.00 g, 47.1 mmol) and triethylamine (TEA, 9.53 g, 94.2 mmol) was slowly added phosphorus oxychloride (POCl3, 5.2 mL, 56.8 mmol) at 25 °C. Subsequently, the reaction mixture was heated to 80 °C and stirred at this temperature for 3.0 hours. Upon completion of the reaction, the mixture was cooled to 25 °C and diluted with the addition of toluene (100 mL). The organic phase was separated, washed with ice water (50 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated by decompression to afford the title compound 4-chloro-6-nitroquinazoline as a yellow solid (7.00 g, 64.2% yield). The structure of the compound was confirmed by the following spectral data: 1H NMR (400 MHz, DMSO-d6) δ: 8.78 (s, 1H), 8.54 (d, J = 6.8 Hz, 1H), 8.39 (s, 1H), 7.87 (d, J = 12.4 Hz, 1H).
References
[1] Patent: CN108373452, 2018, A. Location in patent: Paragraph 0010; 0024; 0036-0041; 0050-0053
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 12, p. 3974 - 3980
[3] Chinese Journal of Chemistry, 2014, vol. 32, # 6, p. 538 - 544
[4] Patent: WO2014/177038, 2014, A1. Location in patent: Paragraph 00255-00256
[5] Tetrahedron Letters, 2012, vol. 53, # 6, p. 674 - 677
4-CHLORO-6-NITROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 4-CHLORO-6-NITROQUINAZOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | 4-CHLORO-6-NITROQUINAZOLINE
19815-16-8
|
US $6.60 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 4-CHLORO-6-NITROQUINAZOLINE
19815-16-8
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co
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