5-Methoxy-2,4-pyrimidinediol
- CAS No.
- 6623-81-0
- Chemical Name:
- 5-Methoxy-2,4-pyrimidinediol
- Synonyms
- mo5Ura;NSC 55452;5-METHOXYURACIL;4-pyrimidinediol;Fluorouracil Impurity D;Fluorouracil EP ImpurityD;Fluorouracil BP Impurity D;5-METHOXYPYRIMIDINE-2,4-DIOL;5-Methoxy-2,4-pyrimidinediol;5-Methoxypyrimidine-2,4-dione
- CBNumber:
- CB1451247
- Molecular Formula:
- C5H6N2O3
- Molecular Weight:
- 142.11
- MDL Number:
- MFCD03428618
- MOL File:
- 6623-81-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,4-Dihydroxy-5-methoxypyrimidine >98.0%(GC)(T) | D4599 | 1g | $72 |
| 2,4-Dihydroxy-5-methoxypyrimidine >98.0%(GC)(T) | D4599 | 5g | $218 |
| 5-Methoxyuracil | M271750 | 2g | $135 |
| 5-Methoxyuracil | 016446 | 2.5g | $446 |
| 5-METHOXYURACIL 95.00% | NUC0000385 | 500MG | $475 |
| More product size | |||
| Melting point | 344°C(lit.) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly, Heated), Water (Slightly, Heated) |
| pka | 8.17±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Major Application | pharmaceutical small molecule |
| InChI | InChI=1S/C5H6N2O3/c1-10-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) |
| InChIKey | KELXHQACBIUYSE-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(OC)C(=O)N1 |
| CAS DataBase Reference | 6623-81-0(CAS DataBase Reference) |
| FDA UNII | 79DD14XTQR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P305+P351+P338-P362+P364 |
| HazardClass | IRRITANT |
| HS Code | 2933599590 |
5-Methoxy-2,4-pyrimidinediol price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4599 | 2,4-Dihydroxy-5-methoxypyrimidine >98.0%(GC)(T) | 6623-81-0 | 1g | $72 | 2025-07-31 | Buy |
| TCI Chemical | D4599 | 2,4-Dihydroxy-5-methoxypyrimidine >98.0%(GC)(T) | 6623-81-0 | 5g | $218 | 2025-07-31 | Buy |
| TRC | M271750 | 5-Methoxyuracil | 6623-81-0 | 2g | $135 | 2021-12-16 | Buy |
| Usbiological | 016446 | 5-Methoxyuracil | 6623-81-0 | 2.5g | $446 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | NUC0000385 | 5-METHOXYURACIL 95.00% | 6623-81-0 | 500MG | $475 | 2021-12-16 | Buy |
5-Methoxy-2,4-pyrimidinediol Chemical Properties,Uses,Production
Chemical Properties
Beige powder
Uses
5-Methoxy-2,4-pyrimidinediol is used as building block in chemical synthesis, it is also used in the preparation of nucleosides.
Uses
5-Methoxyuracil is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.
Uses
5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.
Synthesis
6939-11-3
6623-81-0
A reflux reaction was carried out for 2 hours using 5-methoxy-2-thio-2,3-dihydropyrimidin-4(1H)-one (21.5 g, 0.137 mol) as starting material, mixed with chloroacetic acid (21.5 g, 0.227 mol) in water (585 mL). Subsequently, concentrated hydrochloric acid (85 mL) was added to the reaction system and the reflux reaction was continued for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was precipitated. The solid was collected by filtration, washed with water and dried to afford 5-methoxy-2,4-dihydroxypyrimidine (18.2 g, 94% yield). Mass spectrometry analysis showed (M + H)+ = 143.
References
[1] Patent: US2008/182852, 2008, A1. Location in patent: Page/Page column 15
5-Methoxy-2,4-pyrimidinediol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 |
View Lastest Price from 5-Methoxy-2,4-pyrimidinediol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 5-Methoxy-2,4-pyrimidinediol
6623-81-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-06-20 | 5-Methoxy-2,4-pyrimidinediol
6623-81-0
|
US $1.00 / kg | 1kg | HPLC 98.0% | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2019-07-06 | 5-Methoxy-2,4-pyrimidinediol
6623-81-0
|
US $8.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 5-Methoxy-2,4-pyrimidinediol
6623-81-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 5-Methoxy-2,4-pyrimidinediol
6623-81-0
- US $1.00 / kg
- HPLC 98.0%
- Hebei Yanxi Chemical Co., Ltd.
-
- 5-Methoxy-2,4-pyrimidinediol
6623-81-0
- US $8.00 / kg
- 98%
- Career Henan Chemical Co
