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ChemicalBook >> CAS DataBase List >>3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Structure
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide structure
CAS No.
612514-42-8
Chemical Name:
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Synonyms
VU0152099;VU0152099, 10 mM in DMSO;3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-;3-Amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;3-amino-N-[(2H-1,3-benzodioxol-5-yl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;acetylcholine,Inhibitor,VU0152099,Muscarinic acetylcholine receptor,mAChR,PAM,neuroprotective,inhibit
CBNumber:
CB14617038
Molecular Formula:
C18H17N3O3S
Molecular Weight:
355.41
MDL Number:
MOL File:
612514-42-8.mol
Last updated:2025-04-17 18:22:24
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3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Properties

Boiling point 622.9±55.0 °C(Predicted)
Density 1.403±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 13.05±0.46(Predicted)

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Chemical Properties,Uses,Production

Uses

VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 μM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine[1].

Biological Activity

VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 μM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine[1]. VU0152099 (30 μM) induces a dose-dependent leftward shift of the acetylcholine (ACh) concentration response curve (CRC) with maximal shifts of 30-fold observed with 30 μM. VU0152099 dose-dependently potentiates the response to an EC20 concentration of ACh with EC50 values of 1.2 μM, and increases the maximal response to ACh to approximately 130%. VU0152099 is a potent positive allosteric modulator that enhance the response of the M4 receptor to the endogenous agonist ACh[1]. VU0152099 (56.6 mg/kg; i.p.; once) reverses Amphetamine-induced hyperlocomotion in rats[1].

in vivo

VU0152099 (56.6 mg/kg; i.p.; once) reverses Amphetamine-induced hyperlocomotion in rats[1].

Animal Model:Male Sprague-Dawley rats (270-300 g) injected with Amphetamine[1]
Dosage:56.6 mg/kg
Administration:i.p.; once
Result:Reversed Amphetamine-induced hyperlocomotion in rats.

References

[1]. Ashley E Brady, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Suppliers

Global( 16)Suppliers
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BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4611 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6439 55
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62072 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24863 58
Aikon International Limited 18626450290 yftan@aikonchem.com China 10715 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 7328 58
Shanghai Jieshikai Biotechnology Co. , Ltd. 021-57520305 15801958784 lihua@jskchem.com China 49234 58
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Aikon International Limited 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Jieshikai Biotechnology Co. , Ltd. 58

View Lastest Price from 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VU0152099 pictures 2024-11-19 VU0152099
612514-42-8
 US $29.00-98.00 / mg 98.46% 10g TargetMol Chemicals Inc.
  • VU0152099 pictures
  • VU0152099
    612514-42-8
  • US $29.00-98.00 / mg
  • 98.46%
  • TargetMol Chemicals Inc.

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Spectrum

3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide(612514-42-8)1HNMR
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide VU0152099 3-Amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide acetylcholine,Inhibitor,VU0152099,Muscarinic acetylcholine receptor,mAChR,PAM,neuroprotective,inhibit Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl- 3-amino-N-[(2H-1,3-benzodioxol-5-yl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide VU0152099, 10 mM in DMSO 612514-42-8