Methyl 3-amino-6-bromopyrazine-2-carboxylate
- CAS No.
- 6966-01-4
- Chemical Name:
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
- Synonyms
- NSC 18700;C6H6BrN3O2-6966-01-4;Favipiravir Impurity 24;Favipiravir Impurity 17;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLATE;Methyl 3-amino-6-bromopyrazine-2-formate;2-Amino-5-bromo-3-(methoxycarbonyl)pyrazine;METHYL 3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLATE;Methyl 6-broMo-3-aMino-2-pyrazinecarboxylate;Methyl 6-BroMo-3-aMinopyrazine-2-carboxylate
- CBNumber:
- CB1462247
- Molecular Formula:
- C6H6BrN3O2
- Molecular Weight:
- 232.03
- MDL Number:
- MFCD00834964
- MOL File:
- 6966-01-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 3-amino-6-bromopyrazine-2-carboxylate 95% | 737313 | 250MG | $59.4 |
| Methyl 3-Amino-6-bromopyrazine-2-carboxylate >98.0%(GC) | M2655 | 1g | $38 |
| Methyl 3-Amino-6-bromopyrazine-2-carboxylate >98.0%(GC) | M2655 | 5g | $162 |
| 2-Amino-5-bromopyrazine-3-carboxylic Acid, Methyl Ester | A1375-87 | 1g | $368 |
| 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester | TRC-A601863-5G | 5g | $270 |
| More product size | |||
| Melting point | 164-166C |
|---|---|
| Boiling point | 322.4±37.0 °C(Predicted) |
| Density | 1.754±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, Ethyl Acetate, Methanol |
| pka | -1.74±0.10(Predicted) |
| form | Solid |
| color | Off-white to yellow |
| InChI | InChI=1S/C6H6BrN3O2/c1-12-6(11)4-5(8)9-2-3(7)10-4/h2H,1H3,(H2,8,9) |
| InChIKey | CNXSIRHOIFRMOB-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(Br)=CN=C1N |
| CAS DataBase Reference | 6966-01-4 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
Methyl 3-amino-6-bromopyrazine-2-carboxylate price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 737313 | Methyl 3-amino-6-bromopyrazine-2-carboxylate 95% | 6966-01-4 | 250MG | $59.4 | 2023-01-07 | Buy |
| TCI Chemical | M2655 | Methyl 3-Amino-6-bromopyrazine-2-carboxylate >98.0%(GC) | 6966-01-4 | 1g | $38 | 2026-04-30 | Buy |
| TCI Chemical | M2655 | Methyl 3-Amino-6-bromopyrazine-2-carboxylate >98.0%(GC) | 6966-01-4 | 5g | $162 | 2026-04-30 | Buy |
| Usbiological | A1375-87 | 2-Amino-5-bromopyrazine-3-carboxylic Acid, Methyl Ester | 6966-01-4 | 1g | $368 | 2026-06-03 | Buy |
| TRC | TRC-A601863-5G | 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester | 6966-01-4 | 5g | $270 | 2026-06-03 | Buy |
Methyl 3-amino-6-bromopyrazine-2-carboxylate Chemical Properties,Uses,Production
Chemical Properties
Orange Solid
Uses
Pyrazine derivatives as Axl and C-Met receptor enzyme inhibitors.
Synthesis
16298-03-6
6966-01-4
General Steps: Example 1; Synthesis of 3-methyl-6-(4-(methylsulfonyl)phenyl)-N-phenylpiperazine-2-carboxamide (Compound IV-1) Method A: Step 1: Preparation of methyl 3-amino-6-bromopyrazine-2-carboxylate[A Methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) was mixed with N-bromosuccinimide (9.705 g, 54.53 mmol) in acetonitrile (100 mL), and the reaction was stirred for 16 hours at room temperature. After completion of the reaction, the precipitate was collected by filtration, washed with acetonitrile and dried to afford the target product methyl 3-amino-6-bromopyrazine-2-carboxylate as a yellow solid (11.68 g, 92% yield). 1H NMR (400.0 MHz, DMSO-d6) δ 3.85 (s, 3H), 7.55 (br s, 2H), 8.42 (s, 1H) ppm; MS (ES+) m/z 233.
References
[1] Patent: WO2007/61360, 2007, A2. Location in patent: Page/Page column 71
[2] Heterocycles, 2005, vol. 65, # 10, p. 2321 - 2327
[3] Patent: WO2004/92177, 2004, A1. Location in patent: Page 35-36
[4] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 84-85
[5] Patent: WO2010/54398, 2010, A1. Location in patent: Page/Page column 90
Methyl 3-amino-6-bromopyrazine-2-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from Methyl 3-amino-6-bromopyrazine-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | Methyl 3-amino-6-bromopyrazine-2-carboxylate
6966-01-4
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-04-29 | Methyl 3-amino-6-bromopyrazine-2-carboxylate
6966-01-4
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | Methyl 3-amino-6-bromopyrazine-2-carboxylate
6966-01-4
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
6966-01-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
6966-01-4
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- Methyl 3-amino-6-bromopyrazine-2-carboxylate
6966-01-4
- $8.00
- 99%
- Career Henan Chemical Co
