SN-32976
- CAS No.
- 1246202-11-8
- Chemical Name:
- SN-32976
- Synonyms
- SN-32976;SN-32976,SN32976;Ethanamine, 2-[[4-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-1-piperazinyl]sulfonyl]-N,N-dimethyl-
- CBNumber:
- CB14668520
- Molecular Formula:
- C24H33F2N9O4S
- Molecular Weight:
- 581.64
- MDL Number:
- MOL File:
- 1246202-11-8.mol
SN-32976 Chemical Properties,Uses,Production
Description
SN32976 is a novel potent pi3kα inhibitor
Uses
SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC50s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. SN32976 shows high selectivity among other 442 kinases. SN32976 shows anticancer effects[1].
in vivo
SN32976 (37.5-75 mg/kg; po; daily; for 21 days) inhibits tumor growth in U-87 MG tumor xenograft models[1].
| Animal Model: | 6-8 week old female balb/c nude or female balb/c Rag1?/? mice inoculated with U-87 MG cells[1] |
| Dosage: | 37.5 mg/kg; 75 mg/kg |
| Administration: | po; daily; for 21 days |
| Result: | Inhibited tumor growth in U-87 MG tumor xenograft models. |
IC 50
PI3Kα: 15.1 nM (IC50); PI3Kβ: 461 nM (IC50); PI3Kγ: 110 nM (IC50); PI3Kδ: 134 nM (IC50); mTOR: 194 nM (IC50)
References
[1] Gordon W Rewcastle, et al. Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. Oncotarget. 2017 Jul 18;8(29):47725-47740. DOI:10.18632/oncotarget.17730
SN-32976 Preparation Products And Raw materials
Raw materials
Preparation Products
SN-32976 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
| Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. | 021-58521787 17701827760 | starpharmsh@gmail.com | China | 208 | 58 |
| Shenyang Maud Pharmaceutical Technology Co., Ltd. | 024-23982345 | 1020788318@qq.com | China | 2251 | 58 |
| Shanghai Botuo Biotechnology Co., LTD | 16621358918 | botuopharma888@163.com | China | 9208 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18478 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
