PROTEIN C
- CAS No.
- 42617-41-4
- Chemical Name:
- PROTEIN C
- Synonyms
- APC;DP2.5;PROTEIN C;APC, HUMAN;APC protein;HUMAN PROTEIN C;fromhumanplasma;PROTEIN C, HUMAN;activated protein c;PROTEIN C, ACTIVATED
- CBNumber:
- CB1469635
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00165567
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | H2O: 1 mg/mL |
| form | lyophilized powder |
| biological source | rabbit |
| Water Solubility | H2O: 1mg/mL |
| FDA UNII | 3Z6S89TXPW |
| NCI Dictionary of Cancer Terms | APC |
| ATC code | B01AD12 |
| UNSPSC Code | 12352203 |
| NACRES | NA.61 |
SAFETY
Risk and Safety Statements
| Hazard Codes | B |
|---|---|
| Risk Statements | 36/37 |
| Safety Statements | 36/37-36-26 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
PROTEIN C price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4200594 | Anti-APC (C-terminal) antibody produced in rabbit ~1.0?mg/mL, affinity isolated antibody | 42617-41-4 | 200μL | $565 | 2026-04-30 | Buy |
| Sigma-Aldrich | P2200 | Protein C from human plasma Activated, lyophilized powder, ≥90% (SDS-PAGE) | 42617-41-4 | 0.1mg | $664 | 2026-04-30 | Buy |
| Sigma-Aldrich | 539218 | Protein C, Activated, Human Plasma | 10 μg | $597 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 539215 | Protein C, Human Plasma | 100 μg | $578 | 2026-04-30 | Buy | |
| Usbiological | P9102-36 | Protein C >95%(SDS-PAGE) | 100ug | $255 | 2026-06-04 | Buy |
PROTEIN C Chemical Properties, Uses, Production
Description
Drotrecogin alfa was introduced in the US as a new intravenous treatment for the reduction of mortality in adult patients with severe sepsis associated with acute organ dysfunction. Drotrecogin aifa is the first recombinant activated protein C expressed in human kidney 293 cells. Activated protein C1 an endogenous serine protease, acts as an antithrombotic via inhibition of factor Va and Vllla, promotes fibrinolysis via inactivation of plasminogen-activator inhibitor-1 and exerts an anti-inflammatory effect by inhibiting the production of inflammatory cytokines (tumor necrosis factor-alpha, interieukin-1 and 6) by monocytes. It was shown that the majority of patients with sepsis have reduced levels of activated protein C. In a baboon model of lethal E. coli sepsis, administration of activated protein C reduced mortality. In a phase III clinical trial, intravenous infusion of drotrecogin alfa at a dose of 24 μg/kg/h over 96 h significantly reduced the risk of death compared with placebo in patients with severe sepsis. However, an increased risk of serious bleeding has been associated with the administration of the drug.
Originator
Lilly (US)
Uses
Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.
brand name
Xigris
General Description
Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.
Biochem/physiol Actions
Adenomatous Polyposis Coli (APC) has a key role in the proteasome-mediated degradation of β-catenin. APC mutations cause accumulation of β-catenin in the nucleus leading to activation of LEF-1 and/or TCF, and the induction of target genes such as the oncogene c-myc. It is involved in regulation of mitotic chromosome separation and stability.
PROTEIN C Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4688 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Shanghai Jinshi Biochemical Technology Co., Ltd | 18601717983 18601717983 | 291017736@qq.com | China | 499 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
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