Roxatidine
- CAS No.
- 78273-80-0
- Chemical Name:
- Roxatidine
- Synonyms
- ROXATIDINE;desacetyl-TZU-0460;Roxatidine USP/EP/BP;RoxatidineAcetateHclBase;Roxatidine in acetonitrile;ROXATIDINE ENTERPRISE STANDARD;ROXATIDINE(SUBJECTTOPATENTFREE);Benzaldehyde,5-methoxy-7-nitro-;n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide;2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide
- CBNumber:
- CB1472068
- Molecular Formula:
- C17H26N2O3
- Molecular Weight:
- 306.4
- MDL Number:
- MFCD00871807
- MOL File:
- 78273-80-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| ROXATIDINE 95.00% | API0005304 | 5MG | $504.65 |
| Melting point | 59-60 °C |
|---|---|
| Boiling point | 524.3±45.0 °C(Predicted) |
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | oil |
| pka | 13.34±0.10(Predicted) |
| color | Colorless to pale yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 78273-80-0(CAS DataBase Reference) |
| FDA UNII | IV9VHT3YUM |
| ATC code | A02BA06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Roxatidine Chemical Properties,Uses,Production
Description
Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
Uses
Anti-ulcerative.
in vivo
Roxatidine (20 mg/kg, p.o., a single dose for 1h before Compound 48/80 injection) ameliorates Compound 48/80 (HY-115768) (8mg/kg, i.p., a single dose for 1h)-induced allergic hypersensitivity and suppresses Compound 48/80-induced allergic inflammation in anaphylactic animal model[1].
| Animal Model: | Compound 48/80-induced anaphylactic shock mouse model[1] |
| Dosage: | 20 mg/kg |
| Administration: | p.o., a single dose for 1h before Compound 48/80 injection |
| Result: | Increased the survival rate to 20% at 60 min after compound 48/80 injection. |
IC 50
H2 Receptor
References
[1] J G MILLS J R W. The pharmacology of histamine H2-receptor antagonists.[J]. Methods and findings in experimental and clinical pharmacology, 1989, 11 Suppl 1: 87-95.
[2] EU-JIN CHO. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages†[J]. Journal of cellular biochemistry, 2011, 112 12: 3648-3659. DOI:10.1002/jcb.23294
[3] HIROYUKI IMAEDA. Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia.[J]. Journal of Gastroenterology, 2011, 46 11: 1267-1272. DOI:10.1007/s00535-011-0447-1
[4] RENHAO ZE. Roxatidine Attenuates Degradation of Extracellular Matrix.[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017: 1156-1160. DOI:10.1016/j.biopha.2017.08.130
Roxatidine Preparation Products And Raw materials
Roxatidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13799 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15080 | 58 |
View Lastest Price from Roxatidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | Roxatidine
78273-80-0
|
US $1.00-1.00 / Kg/Bag | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-01-27 | Roxatidine
78273-80-0
|
US $0.00-0.00 / kg | 1kg | 99% | 20tons | Sinoway Industrial co., ltd. | |
 |
2025-06-27 | Roxatidine
78273-80-0
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Roxatidine
78273-80-0
- US $1.00-1.00 / Kg/Bag
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Roxatidine
78273-80-0
- US $0.00-0.00 / kg
- 99%
- Sinoway Industrial co., ltd.
-
- Roxatidine
78273-80-0
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
