ChemicalBook >> CAS DataBase List >>6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE
- CAS No.
- 613263-00-6
- Chemical Name:
- 6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE
- Synonyms
- M62812;M62812,M-62812;M62812, 10 mM in DMSO;6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE;6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
- CBNumber:
- CB14735206
- Molecular Formula:
- C13H12ClN3OS
- Molecular Weight:
- 293.77
- MDL Number:
- MFCD30179737
- MOL File:
- 613263-00-6.mol
Last updated:2025-04-29 15:35:11
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | 89MSZ2934C |
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE price
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
M62812 is a toll-like receptor 4 (TLR4) transduction inhibitor and also suppresses endothelial cell and leukocyte activation, preventing lethal septic shock in mice.
in vivo
M62812 (i.v.; 10-20 mg/kg; single dose) is protective and reduces inflammatory and coagulation parameters in a D-galactosamine-sensitized endotoxin shock mouse model[1].
M62812 (i.v.; 20 mg/kg; once a day for three days) prevents mice from lethality in a murine cecal ligation and puncture model[1].
| Animal Model: | D-galactosamine-sensitized endotoxin shock mouse model[1] |
| Dosage: | 10-20 mg/kg |
| Administration: | Intravenous administration (i.v.) |
| Result: | Prevented elevation of TNF-α, IL-6, soluble E-selectin, thrombin/antithrombin complexes and glutamic pyruvic transaminase activity at 20 mg/kg. Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model. |
| Animal Model: | Cecal ligation and puncture mouse model[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous administration (i.v.); once a day for three days |
| Result: | Reduced mortality in a murine cecal ligation and puncture model. |
storage
Store at +4°C
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE Suppliers
Global( 20)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Block Chemical Technology (Shanghai) Co., LTD | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 9450 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 55017 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2978 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5527 | 58 |
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6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE
6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
M62812
M62812,M-62812
M62812, 10 mM in DMSO
613263-00-6