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3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one structure

CAS No.: 158299-05-9

Chemical Name:: 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one

Synonyms: BPSBC;BR-Comp;-cyclohexan]-4-one;3-(2-Bromo-1-oxoprop;Meropenem Intermediate;-cyclohexan]-4(3H)-one;Bromopropyl spirobenzoxazine cyclohexane;Bromopropionylspirobenzoxazinecyclohexane(BPSBC);3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cycloh...

CBNumber:: CB1474587

Molecular Formula:: C16H18BrNO3

Molecular Weight:: 352.22

MDL Number:: MFCD08458252

MOL File:: 158299-05-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:40

Product description	Number	Pack Size	Price
3-(2-Bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one	7942AA	25g	$39
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one	FB148247	50mg	$75
3-(2-Bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one	7942AA	100g	$112
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one	FB148247	100mg	$130
3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one	FB148247	250mg	$260
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3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one Properties

Melting point	74-76 °C
Boiling point	485.0±45.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
Flash point	247.1°C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-2.33±0.20(Predicted)
InChI	InChI=1S/C16H18BrNO3/c1-11(17)14(19)18-15(20)12-7-3-4-8-13(12)21-16(18)9-5-2-6-10-16/h3-4,7-8,11H,2,5-6,9-10H2,1H3
InChIKey	APCHXTHKSJHPPE-UHFFFAOYSA-N
SMILES	O1C2=CC=CC=C2C(=O)N(C(=O)C(Br)C)C21CCCCC2
CAS DataBase Reference	158299-05-9

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07,GHS08,GHS09
Signal word	Warning
Hazard statements	H290-H302-H319-H334-H410
Precautionary statements	P261-P264b-P270-P280i-P285-P301+P312-P304+P341-P305+P351+P338-P330-P337+P313-P342+P311-P390-P406b-P501c

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	7942AA	3-(2-Bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one	158299-05-9	25g	$39	2021-12-16	Buy
Biosynth Carbosynth	FB148247	3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one	158299-05-9	50mg	$75	2021-12-16	Buy
AK Scientific	7942AA	3-(2-Bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one	158299-05-9	100g	$112	2021-12-16	Buy
Biosynth Carbosynth	FB148247	3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one	158299-05-9	100mg	$130	2021-12-16	Buy
Biosynth Carbosynth	FB148247	3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one	158299-05-9	250mg	$260	2021-12-16	Buy

Product number	Packaging	Price	Buy
7942AA	25g	$39	Buy
FB148247	50mg	$75	Buy
7942AA	100g	$112	Buy
FB148247	100mg	$130	Buy
FB148247	250mg	$260	Buy

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one Chemical Properties,Uses,Production

Chemical Properties

yellow powder.

Uses

3-(2-Bromo-1-oxopropyl)-spiro[2h-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one is an intermediate of meropenem, and meropenem is a carbapenem antibiotic, which is suitable for the treatment of meningitis.

Application

A useful research chemical compound.

Synthesis

spiro[3H-1,3-benzoxazine-2,1'-cyclohexane]-4-one

40033-95-2

563-76-8

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one

158299-05-9

Comparative Example 1: 1.4,80 g of spiro[benzo[e][1,3]oxazine-2,1'-cyclohexyl]-4(3H)-one, 127 g of 2-bromopropionyl bromide, and 40 g of pyridine (molar ratio 1:1.6:1) were dissolved in chlorobenzene (mass ratio 1:4.4). The mixture was placed in a four-necked flask under nitrogen protection and reacted at 50 °C for 8 hours. After completion of the reaction, the mixture was washed three times with 200 g of water, three times with 200 g of 10% potassium hydroxide solution and three times with 200 g of water, in that order. The organic phases were combined and concentrated under reduced pressure to remove the solvent to obtain a colorless liquid. To this liquid was added 80 g of ethanol (mass ratio 1:1), cooled to -5 °C, stirred for 2 h, filtered and dried to give 109 g of 3-(2-bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1 '-cyclohexyl]-4(3H)-one. The molar yield was 84.5% and the purity was 97.9%.

storage

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

References

[1] Journal of Organic Chemistry, 1995, vol. 60, # 5, p. 1096 - 1097
[2] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 23, p. 2851 - 2856
[3] Journal of Organic Chemistry, 1997, vol. 62, # 9, p. 2877 - 2884
[4] Patent: CN106432122, 2017, A. Location in patent: Paragraph 0070-0072
[5] Patent: US5442055, 1995, A

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one synthesis

Synthesis of 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one from Salicylamide

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one Preparation Products And Raw materials

Raw materials

spiro[3H-1,3-benzoxazine-2,1'-cyclohexane]-4-one Salicylamide 2-Bromopropionyl bromide Chlorobenzene Pyridine

Preparation Products

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one Suppliers

Global( 203)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	+86-0373-3695376 +86-13937349994	HYJM@houyuanjm.com	China	299	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Huaian yishu technology co.,ltd	86-0517-85883738 13852390259	sales@yishuchem.com	CHINA	53	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58

Supplier	Advantage
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Huaian yishu technology co.,ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 158299-05-9	US $5.00-0.10 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-04-04	3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 158299-05-9	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2023-05-31	3-(2-bromo-1-Oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 158299-05-9	US $30.00-28.00 / Kg	1Kg	99.0% up	50 tons per month	Xinxiang Hongqi District Houyuan Trading Co.,Ltd

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one
158299-05-9
US $5.00-0.10 / KG
99%
Henan Fengda Chemical Co., Ltd

3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one
158299-05-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

3-(2-bromo-1-Oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one
158299-05-9
US $30.00-28.00 / Kg
99.0% up
Xinxiang Hongqi District Houyuan Trading Co.,Ltd

158299-05-9(3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one)Related Search:

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Bromine 2-BROMO-N-CYCLOHEXYL-ACETAMIDE N-ACETYLSALICYLAMIDE N-benzyl-2-bromo-propanamide 2-bromo-N,N-diethyl-acetamide

CHEMBRDG-BB 4024589 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one

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3-(2-bromo-1-oxopropyl)-4-spiro[1,3-benzoxazine-2,1'-cyclohexane]one -cyclohexan]-4-one BPSBC BR-Comp 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-ketone 3-(2-Bromo-1-oxoprop 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one (BPSBC) 3-(2-broMopropionyl)spiro[2H-1,3-benzoxazine-2,1'-cyclohexane]-4(3H)-one broMine propionyl snails benzoxazin cyclohexane-3-(2-broMine-generation-1-oxo-propyl)-Lo [2H-1,3-benzoxazine -2,1'-cyclohexane]-4(3H)-ketone 3-isobutyrylspiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one 3-(2-BroMo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one (M2) Meropenem Intermediate Spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one, 3-(2-bromo-1-oxopropyl)- 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one USP/EP/BP 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cycloh... -(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 3-(2-Bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one(BPSBC) Bromopropionylspirobenzoxazinecyclohexane(BPSBC) Bromopropyl spirobenzoxazine cyclohexane 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 3-(2-Bromopropanoyl)spiro[benzo[e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1' -cyclohexan]-4(3H)-one 158299-05-9 C16H18BrNO3 158299-05-9