DBCO-PEG4-amine
- CAS No.
- 1840886-10-3
- Chemical Name:
- DBCO-PEG4-amine
- Synonyms
- DBCO-CONH-PEG4-amine;DBCO-PEG4-amine TFA salt;DBCO-PEG2-amine TFA salt;Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-;N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
- CBNumber:
- CB14849428
- Molecular Formula:
- C29H37N3O6
- Molecular Weight:
- 523.63
- MDL Number:
- MOL File:
- 1840886-10-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| DBCO-PEG4-amineTFAsalt 98% | BP-23958 | 50mg | $280 |
| DBCO-PEG4-amineTFAsalt 98% | BP-23958 | 100mg | $480 |
| DBCO-PEG4-amine | CS-0107922 | 50mg | $980 |
| DBCO-PEG4-amine | CS-0107922 | 100mg | $1500 |
| DBCO-PEG4-amineTFAsalt 98% | BP-23958 | 500mg | $1650 |
| Boiling point | 784.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 15.14±0.46(Predicted) |
| form | Viscous Liquid |
| color | Light yellow to yellow |
| InChIKey | NFJQULPXXATMFO-UHFFFAOYSA-N |
| SMILES | C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN |
DBCO-PEG4-amine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-23958 | DBCO-PEG4-amineTFAsalt 98% | 1840886-10-3 | 50mg | $280 | 2021-12-16 | Buy |
| BroadPharm | BP-23958 | DBCO-PEG4-amineTFAsalt 98% | 1840886-10-3 | 100mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0107922 | DBCO-PEG4-amine | 1840886-10-3 | 50mg | $980 | 2021-12-16 | Buy |
| ChemScene | CS-0107922 | DBCO-PEG4-amine | 1840886-10-3 | 100mg | $1500 | 2021-12-16 | Buy |
| BroadPharm | BP-23958 | DBCO-PEG4-amineTFAsalt 98% | 1840886-10-3 | 500mg | $1650 | 2021-12-16 | Buy |
DBCO-PEG4-amine Chemical Properties,Uses,Production
Description
DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.
Biological Activity
DBCO-PEG4-amine is a PROTAC bridge and belongs to the PEG class. DBCO-PEG4-amine can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 | 1924344760@confluore.cn | China | 2997 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 1125 | 58 |
| HUBEI DING KOSIN TECHNOLOGY | +8613524650931 | jason@kosinbio.com | China | 953 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939; 15221275939 | shenlinxing@macklin.cn | China | 15781 | 55 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3840 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4952 | 58 |
View Lastest Price from DBCO-PEG4-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-07 | DBCO-PEG4-amine
1840886-10-3
|
US $0.00 / mg | 50mg | >99.00% | 250 | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-PEG4-amine
1840886-10-3
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.
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