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(-)-Bis[(S)-1-phenylethyl]amine

(-)-Bis[(S)-1-phenylethyl]amine structure

CAS No.: 56210-72-1

Chemical Name:: (-)-Bis[(S)-1-phenylethyl]amine

Synonyms: (S)-bis((S)-1-phenylethyl)amine;Tamsulosin Impurity 29;bis[(1S)-1-phenylethyl]amine;(S,S)-Bis-(1-phenylethyl)amin;(-)-Bis[(S)-1-phenylethyl]amine;(?)-Bis[(S)-1-phenylethyl]amine;(-)-bis[(s)-α-methylbenzyl]amine;(S)-(-)-Bis-(1-phenylethyl)-amine;(-)-Bis[(S)-1-phenylethyl]amine 99%;(?)-Bis[(S)-1-phenylethyl]amine

CBNumber:: CB1499311

Molecular Formula:: C16H19N

Molecular Weight:: 225.33

MDL Number:: MFCD00243087

MOL File:: 56210-72-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:43:57

Product description	Number	Pack Size	Price
(?)-Bis[(S)-1-phenylethyl]amine 99%	433810	1g	$70.1
(?)-Bis[(S)-1-phenylethyl]amine 99%	433810	10g	$384
Bis[(S)-1-phenylethyl]amine	FB168367	100g	$1238
Bis[(S)-1-phenylethyl]amine	FB168367	500g	$2750
Bis[(S)-1-phenylethyl]amine	FB168367	1000g	$4130
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(-)-Bis[(S)-1-phenylethyl]amine Properties

Melting point	~260 °C
Boiling point	86 °C0.05 mm Hg(lit.)
alpha	-197 º (NEAT)
Density	0.987 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5525(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	readily sol common organic solvents (ether, THF, chloroform, etc.); insol H2O.
pka	8.79±0.29(Predicted)
form	liquid
color	Clear, colourless
optical activity	[α]/D 159°, c = 2 in ethanol
Water Solubility	Immiscible with water.
InChI	InChI=1S/C16H19N/c1-13(15-9-5-3-6-10-15)17-14(2)16-11-7-4-8-12-16/h3-14,17H,1-2H3/t13-,14-/m0/s1
InChIKey	NXLACVVNHYIYJN-KBPBESRZSA-N
SMILES	N([C@H](C1=CC=CC=C1)C)[C@H](C1=CC=CC=C1)C
CAS DataBase Reference	56210-72-1
FDA UNII	5D97T2Y7WU
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

HS Code

2921199990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

(-)-Bis[(S)-1-phenylethyl]amine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	433810	(?)-Bis[(S)-1-phenylethyl]amine 99%	56210-72-1	1g	$70.1	2026-04-30	Buy
Sigma-Aldrich	433810	(?)-Bis[(S)-1-phenylethyl]amine 99%	56210-72-1	10g	$384	2026-04-30	Buy
Biosynth	FB168367	Bis[(S)-1-phenylethyl]amine	56210-72-1	100g	$1238	2026-06-04	Buy
Biosynth	FB168367	Bis[(S)-1-phenylethyl]amine	56210-72-1	500g	$2750	2026-06-04	Buy
Biosynth	FB168367	Bis[(S)-1-phenylethyl]amine	56210-72-1	1000g	$4130	2026-06-04	Buy

Product number	Packaging	Price	Buy
433810	1g	$70.1	Buy
433810	10g	$384	Buy
FB168367	100g	$1238	Buy
FB168367	500g	$2750	Buy
FB168367	1000g	$4130	Buy

(-)-Bis[(S)-1-phenylethyl]amine Chemical Properties,Uses,Production

Uses

(-)-Bis[(S)-1-phenylethyl]amine is used as a chiral resolution reagent in organic synthesis.

Preparation

Preparative Methods of (-)-(S,S)-α,α′-Dimethyldibenzylamine: minor improvements to the original catalytic hydrogenation procedure have been described (eq 1). This method provides (S,S)-(-)-(1) with an optical purity of only 70%. Enantiomerically pure (S,S)-(-)-(1) can be obtained by recrystallization of the hydrochloride salt of this enriched material from water or the benzoate salt from isopropanol. A chemical reduction procedure has also been described that yields optically active (S,S)-(1) with 74% enantiomeric excess (eq 2). A significant improvement to the former procedures is the diastereoselective hydrogenation of imines catalyzed by rhodium/chiral diphosphines, which yields (S,S)-(1) with an optical purity of 99.4% (eq 3).
(-)-Bis[(S)-1-phenylethyl]amine synthesis

General Description

(-)-(S,S)-α,α′-Dimethyldibenzylamine is a starting material for the formation of chiral amide reagents; useful in the stereospecific deprotonation of prochiral ketones, and as a chirality transfer agent in the reactions of prochiral enolates; stereoselective conjugate addition of organometallic reagents to unsaturated carbonyl systems.^[1]

storage

(-)-(S,S)-α,α′-Dimethyldibenzylamine is no special precautions have been noted in the literature. The free base is a clear distillable liquid that should be stored under an inert atmosphere to prevent air oxidation. Long term storage may lead to some coloration of the material.

Purification Methods

Purification of (-)-(S,S)-α,α′-Dimethyldibenzylamine: the free base can be distilled. The HCl salt can be recrystallized from water, which removes diastereomeric impurities. The benzoate salt can be recrystallized from isopropanol.

References

1. (a) Eleveld, M. B.; Hogeveen, H.; Schudde, E. P. JOC 1986, 51, 3635. (b) Yoshida, T.; Harada, K. BCJ 1972, 45, 3706.

(-)-Bis[(S)-1-phenylethyl]amine Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Toluene Sodium borohydride Acetophenone L-1-Phenylethylamine

Tetrahydrofuran HEAVY DISTILLATE

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Preparation Products

(-)-Bis[(S)-1-phenylethyl]amine Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16512	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3991	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Alfa Chemistry		info@alfa-chemistry.com	United States	2344	58
Bio Connect Life Sciences		info@bio-connect.nl	United States	261	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19632	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
Career Henan Chemica Co	58
Alfa Chemistry	58
Bio Connect Life Sciences	58
Aceschem Inc.	58

View Lastest Price from (-)-Bis[(S)-1-phenylethyl]amine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-17	(RS)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE 56210-72-1	$2.20-8.80	1KG	99%		ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(RS)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE
56210-72-1
$2.20-8.80
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(-)-Bis[(S)-1-phenylethyl]amine Spectrum

(-)-Bis[(S)-1-phenylethyl]amine(56210-72-1)IR

56210-72-1((-)-Bis[(S)-1-phenylethyl]amine)Related Search:

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(S-(R* R*))-(-)-BIS(ALPHA-METHYLBENZYL)& (-)-Bis[(S)-1-phenylethyl]amine, 99% (99+% EE/GLC) (S,S)-Bis-(1-phenylethyl)amin (-)-bis[(s)-α-methylbenzyl]amine (S)-(-)-Bis-(1-phenylethyl)-amine hydrochloride (-)-Bis[(S)-1-phenylethyl]amine, ChiPros 99%, ee 98+% (-)-Bis[(S)-α-methylbenzyl]amine, [S-(R*,R*)]-(-)-Bis(α-methylbenzyl)amine (-)-Bis[(S)-1-phenylethyl]amine (-)-Bis[(S)-1-phenylethyl]aMine, ChiPros|r, 99%, ee 98+% (-)-Bis[(S)-1-phenylethyl]amine 99% (S)-(-)-Bis-(1-phenylethyl)-amine (αS)-α-Methyl-N-[(1S)-1-phenylethyl]benzenemethanamine Benzenemethanamine, α-methyl-N-[(1S)-1-phenylethyl]-, (αS)- Tamsulosin Impurity 29 (?)-Bis[(S)-1-phenylethyl]amine bis[(1S)-1-phenylethyl]amine (?)-Bis[(S)-1-phenylethyl]amine (-)-Bis[(S)-1-Phenylethyl]Amine, Chipros, ee (S)-bis((S)-1-phenylethyl)amine 56210-72-1 C6H5CHCH32NH