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Tetrahydropapaverine hydrochloride

Tetrahydropapaverine hydrochloride structure

CAS No.: 6429-04-5

Chemical Name:: Tetrahydropapaverine hydrochloride

Synonyms: TETRAHYDROALKALI HYDROCHLORIDE;TETRAHYDROPAPAVERINE HCL;Norlaudanosine Hydrochloride;1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride;Nsc118072;Norlaudanosine HCl;NorlaudanosineHydrochloride>DL-NORLAUDANOSINE HYDROCHLORIDE;AtracuriuM Besylate intermediate;rac-Nor Laudanosine Hydrochloride

CBNumber:: CB1501216

Molecular Formula:: C20H25NO4.HCl

Molecular Weight:: 379.8814

MDL Number:: MFCD00035267

MOL File:: 6429-04-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
DL-NORLAUDANOSINE HYDROCHLORIDE Aldrich^CPR	S426016	1 unit	$197
DL-NORLAUDANOSINE HYDROCHLORIDE AldrichCPR	S426016	50MG	$179
Norlaudanosine Hydrochloride >98.0%(HPLC)(N)	N0918	5g	$41
Norlaudanosine Hydrochloride >98.0%(HPLC)(N)	N0918	25g	$166
Tetrahydropapaverine HCl	289841	5g	$340
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Tetrahydropapaverine hydrochloride Properties

Melting point	216.0 to 220.0 °C
storage temp.	Sealed in dry,2-8°C
Water Solubility	Soluble in water
solubility	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form	powder to crystal
color	White to Almost white
InChI	InChI=1S/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H
InChIKey	VMPLLPIDRGXFTQ-UHFFFAOYSA-N
SMILES	C12C=C(C(OC)=CC=1CCNC2CC1=CC=C(OC)C(OC)=C1)OC.Cl
CAS DataBase Reference	6429-04-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P280-P261-P301+P312

Hazard Codes

T,Xn

Risk Statements

Safety Statements

RTECS

NX5070700

HS Code

29334900

NFPA 704

	0
1		0

Tetrahydropapaverine hydrochloride price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S426016	DL-NORLAUDANOSINE HYDROCHLORIDE Aldrich^CPR	6429-04-5	1 unit	$197	2026-04-30	Buy
Sigma-Aldrich	S426016	DL-NORLAUDANOSINE HYDROCHLORIDE AldrichCPR	6429-04-5	50MG	$179	2024-03-01	Buy
TCI Chemical	N0918	Norlaudanosine Hydrochloride >98.0%(HPLC)(N)	6429-04-5	5g	$41	2026-04-30	Buy
TCI Chemical	N0918	Norlaudanosine Hydrochloride >98.0%(HPLC)(N)	6429-04-5	25g	$166	2026-04-30	Buy
Usbiological	289841	Tetrahydropapaverine HCl	6429-04-5	5g	$340	2021-12-16	Buy

Product number	Packaging	Price	Buy
S426016	1 unit	$197	Buy
S426016	50MG	$179	Buy
N0918	5g	$41	Buy
N0918	25g	$166	Buy
289841	5g	$340	Buy

Tetrahydropapaverine hydrochloride Chemical Properties,Uses,Production

Uses

Tetrahydropapaverine hydrochloride is an organic amine compound that can be used as atracuramide intermediate.

Biological Activity

Tetrahydropapaverine (Norlaudanosine), a TIQs, is an analogue of Salsolinol and Tetrahydropapaveroline, and has neurotoxic effects on dopamine neurons.

Synthesis

1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinolinium chloride

5884-22-0

6429-04-5

Crude 3,4-dihydroisoquinoline hydrochloride 12 (6.48 g) was suspended in methanol (50 mL) under argon protection and cooled to 0 °C. Sodium borohydride (0.8 g, 21 mmol) was slowly added to this suspension. The reaction mixture was stirred at room temperature for 10 minutes and then concentrated. Subsequently, brine (16 mL) and acetonitrile (30 mL) were added to the concentrate and the mixture was then partitioned between ethyl acetate (30 mL) and water (30 mL). The aqueous layer was extracted twice with a solvent mixture of ethyl acetate-acetonitrile (30 mL, 1:1). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated to give a yellow oil. This oily substance was dissolved in methanol (10 mL), 5% hydrochloric acid solution in methanol (20 mL) was added and concentrated again. The residue was crystallized by the addition of ether, and the solid was collected by filtration and washed with ether to give finally 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (6-HCl, 4.67 g, 89% yield, after a 3-step reaction) as a white solid with a melting point of 211-215 °C. The 1H NMR (DMSO-d6) data were as follows: δ 2.91 (1H, m), 3.16-3.24 (3H, m), 3.36 (1H, m), 3.56 (1H, m), 3.60 (3H, s), 3.80 (3H, s), 3.85 (6H, s), 4.73 (1H, m), 6.17 (1H, s), 6.58 ( 1H, s), 6.72 (1H, d, J = 8.0 Hz), 6.77-6.79 (2H, m), 9.77 (1H, br s), 10.35 (1H, br s). The 1H NMR (D2O) data were as follows: δ 3.01-3.05 (2H, m), 3.16-3.29 (2H, m), 3.41 (1H, m), 3.53 (1H, m), 3.60 (3H, s), 3.72 (3H, s), 3.83 (6H, s), 4.73 (1H, m), 6.36 (1H, s), 6.73 ( 1H, s), 6.83-6.89 (2H, m), 7.00 (1H, m).

References

[1] Heterocycles, 2014, vol. 8, # 2, p. 1311 - 1321

Tetrahydropapaverine hydrochloride synthesis

Synthesis of Tetrahydropapaverine hydrochloride from 1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinolinium chloride

Tetrahydropapaverine hydrochloride Preparation Products And Raw materials

Raw materials

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline 1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinolinium chloride (+/-)-Tetrahydropapaverine (3,4-Dimethoxyphenyl)acetic acid

3,4-Dimethoxyphenethylamine

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Preparation Products

R-tetrahydropapaverine HCl

Tetrahydropapaverine hydrochloride Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Chongqing Soarwin Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from Tetrahydropapaverine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	Tetrahydropapaverine hydrochloride 6429-04-5	US $31.00-65.00 / mg		99.83%	10g	TargetMol Chemicals Inc.
2025-12-24	Tetrahydropapaverine hydrochloride 6429-04-5	US $0.10 / KG	1KG	98.0%	1000Tons	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	Tetrahydropapaverine hydrochloride 6429-04-5	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Tetrahydropapaverine hydrochloride
6429-04-5
US $31.00-65.00 / mg
99.83%
TargetMol Chemicals Inc.

Tetrahydropapaverine hydrochloride
6429-04-5
US $0.10 / KG
98.0%
Shaanxi Dideu Medichem Co. Ltd

Tetrahydropapaverine hydrochloride
6429-04-5
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

Tetrahydropapaverine hydrochloride Spectrum

Tetrahydropapaverine hydrochloride(6429-04-5)¹HNMR

6429-04-5(Tetrahydropapaverine hydrochloride)Related Search:

Triethylamine hydrochloride Diphenyldimethoxysilane D-Glucosamine hydrochloride Methoxyammonium chloride Dimethyldimethoxysilane

Papaverine hydrochloride (+/-)-Tetrahydropapaverine DL-Carnitine L-Carnitine hydrochloride 1,1-Dimethoxyethane

Isoquinoline Benzyl chloride N,N-Dimethylbenzylamine Topotecan hydrochloride Benzyltriethylammonium chloride

Pyridine hydrochloride PAPAVERINE BOLDINE DIMETHYL ETHER

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1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDETETRAHYDROPAPAVERINE HYDROCHLORIDE tetrahydropapaverine crystalline*hydrochloride TETRAHYDROALKALI HYDROCHLORIDE TETRAHYDROPAPAVERINE HCL 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Tetrahydropapaverine hydrochloride 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINEHYDROCHLORIDETETRAHYDROPAPAVERINEHYDROCHLORIDE 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-dihydroisoquinolineHydrochloride 1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride Nsc118072 Papaverine, 1,2,3,4-tetrahydro-, hydrochloride 1,2,3,4-Tetrahydropapaverine hydrochloride Tetrahrdropapaverine Hydrochloride 1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Norlaudanosine Hydrochloride rac-Nor Laudanosine Hydrochloride Isoquinoline,1-[(3,4-diMethoxyphenyl)Methyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-,hydrochloride (1:1) Norlaudanosine HCl DL-NORLAUDANOSINE HYDROCHLORIDE 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline NorlaudanosineHydrochloride> Papaverine EP Impurity E HCl (Tetrahydropapaverine HCl) TIANFUCHEM--6429-04-5--Tetrahydropapaverine hydrochloride in stock AtracuriuM Besylate intermediate Tetrahydropapaverine (hydrochloride) (Papaverine Impurity) 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-Isoquinoline hydrochloride (1:1) Tetrahydropapavarine Hydrochloride Tetrahydropapaverine crystalline HCL Norlaudanosine Hydrochloride, ≥ 98.0% Tetrahydropapaverine hydrochloride, 10 mM in DMSO etrahydropapaverine hydrochloride RS-Tetrahydropapaverine HCl (RS-THP) 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline HCl 6429-04-5 6429-4-5 6249-04-5 164298-04-5 64929-04-5 C20H25NO4HCl C20H25NO4ClH C20H25NO4HCI Inhibitors