ISOPIMARIC ACID
- CAS No.
- 5835-26-7
- Chemical Name:
- ISOPIMARIC ACID
- Synonyms
- isopimaricaci;Δ7,15-IsopiMaric Acid;7,15-IsopiMaradien-18-oic Acid;13β-Methyl-13-vinylpodocarp-7-en-18-oic acid;13-Methyl-17-norabieta-7,15-diene-18-oic acid;(-)-13β-Methyl-13-vinylpodocarp-7-en-15-oic Acid;1-phenanthrenecarboxylicacid,7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahyd;7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylicaci;(1R,4aR,4bS,7S,10aR)-1,4a,7-Trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthrene-1-carboxylic acid;(1R,4aR,4bS,7S,10aR)-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-triMethyl-1-phenanthrenecarboxylic Acid
- CBNumber:
- CB1503654
- Molecular Formula:
- C20H30O2
- Molecular Weight:
- 302.45
- MDL Number:
- MFCD04113116
- MOL File:
- 5835-26-7.mol
- MSDS File:
- SDS
| Melting point | 160° |
|---|---|
| alpha | D16 -3.6° (10.4% soln in 1:1 alcohol:chloroform) |
| Boiling point | 383.47°C (rough estimate) |
| Density | 1.0434 (rough estimate) |
| refractive index | 1.4980 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: ~26 mg/mL |
| pka | 4?+-.0.60(Predicted) |
| form | solid |
| color | white |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | 1E37K85HHK |
| EPA Substance Registry System | Isopimaric acid (5835-26-7) |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
ISOPIMARIC ACID price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I6783 | Isopimaric Acid ≥98% (GC), powder | 5835-26-7 | 5mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | I6783 | Isopimaric Acid ≥98% (GC), powder | 5835-26-7 | 25mg | $555 | 2024-03-01 | Buy |
| TRC | I821940 | Isopimaric Acid | 5835-26-7 | 100mg | $1390 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BIO0000469 | ISOPIMARIC ACID 95.00% | 5835-26-7 | 100MG | $1963.5 | 2021-12-16 | Buy |
| AK Scientific | 9582AF | Isopimaric Acid | 5835-26-7 | 5mg | $320 | 2021-12-16 | Buy |
ISOPIMARIC ACID Chemical Properties,Uses,Production
Description
Isopimaric acid (5835-26-7) is a terpenoid acid that activates BK (voltage-gated potassium) channels when used at 10 μM in HEK293 cells.1 Improves spatial and non-spatial memory in Alzheimer’s mouse model2,3, and significantly improves motor function in a rat spinal cord injury model4. Reduces hyperactivity of spontaneously active auditory networks, EC50=7.8 μM.5
Uses
A potent novel activators of large-conductance Ca2+-activated K+ channel.
Definition
ChEBI: Isopimaric acid is a diterpenoid, a carbotricyclic compound and a monocarboxylic acid. It is a conjugate acid of an isopimarate. It derives from a hydride of an isopimara-7,15-diene.
General Description
Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.
Biochem/physiol Actions
Potent opener of large conductance calcium activated K+ (BK) channels.
References
Imaizumi et al. (2002), Molecular basis of pimarane compounds as novel activators of large-conductance CA(2+)-activated K(+) channel alpha-subunit; Mol. Pharmacol., 62 836 Wang et al. (2015), Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer’s disease; Neuropharmacology, 92 8 Wang et al. (2015), Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer’s disease model mice; Neuropharmacology, 97 210 Jacobsen et al. (2018), Activation of the Large-conductance, Voltage, and Ca2+-Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat is Neuroprotective; Front. Neurol., 9 1107 Wu et al. (2014), Pharmacodynamics of potassium channel openers in cultured neuronal networks; Eur. J. Pharmacol., 732 68
ISOPIMARIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Huzhou ZhanShu Biotechnology Co.,Ltd | 0572-8889530 18167260939 | zsubio@163.com | China | 369 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jk.info@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6005 | 61 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
View Lastest Price from ISOPIMARIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-05 | ISOPIMARIC ACID
5835-26-7
|
US $1.00 / KG | 1KG | 95--99% | 1ton | Career Henan Chemical Co |
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- ISOPIMARIC ACID
5835-26-7
- US $1.00 / KG
- 95--99%
- Career Henan Chemical Co