ASP4132
- CAS No.
- 1640294-30-9
- Chemical Name:
- ASP4132
- Synonyms
- ASP4132;ASP4132 tosylate;ASP4132, 10 mM in DMSO;anti-cancer,AMPK,xenograft,ASP4132,orally,inhibit,ASP 4132,cancer,breast,AMP-activated protein kinase,Inhibitor,ASP-4132;(6-(1-((6-Methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone bis(4-methylbenzenesulfonate)
- CBNumber:
- CB16187892
- Molecular Formula:
- C39H43F3N6O5S
- Molecular Weight:
- 764.87
- MDL Number:
- MFCD32693927
- MOL File:
- 1640294-30-9.mol
| solubility | DMSO:175.0(Max Conc. mg/mL);186.75(Max Conc. mM) |
|---|---|
| form | Solid |
| color | White to off-white |
| NCI Drug Dictionary | ASP4132 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
ASP4132 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0129453 | ASP4132 98.85% | 1640294-30-9 | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0129453 | ASP4132 98.85% | 1640294-30-9 | 10mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0129453 | ASP4132 98.85% | 1640294-30-9 | 25mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0129453 | ASP4132 98.85% | 1640294-30-9 | 50mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0129453 | ASP4132 98.85% | 1640294-30-9 | 100mg | $1250 | 2021-12-16 | Buy |
ASP4132 Chemical Properties,Uses,Production
Uses
(6-(1-((6-Methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone 4-?Methylbenzenesulfona?te (1:2) is an activate of Adenosine Monophosphate-Activated Protein Kinase (AMPK). Used to treat human cancer.
in vivo
ASP4132 (0.5-8 mg/kg; PO; once daily; for 21 days) causes the tumor growth inhibition and regression[1].
ASP4132 (1 mg/kg; IV or PO) has a T1/2 of 3.6 hours, a CLtot of 19 mL/min?kg, and a Vss of 4.6 L/kg for rats for IV[1].
ASP4132 is stable in human liver microsomes (HLM CLint, vitro=61 mL/min?kg)[1].
| Animal Model: | Five-week-old male nude mice with MDA-MB-453[1] |
| Dosage: | 0.5, 1, 2, 4, 8 mg/kg |
| Administration: | PO; once daily; for 21 days |
| Result: | The tumor growth inhibition (TGI) rate was 29% at 1 mg/kg, and the tumor regression rate was 26%, 87% and 96% at 2, 4 and 8 mg/kg, respectively. |
| Animal Model: | Male SD rats[1] |
| Dosage: | 1 mg/kg (Pharmacokinetic Analysis) |
| Administration: | IV or PO |
| Result: | Had a T1/2 of 3.6 hours, a CLtot of 19 mL/min?kg, and a Vss of 4.6 L/kg for rats for IV. Had a Cmax of 72 ng/mL and an AUC24h of 705 ng?h/mL for PO. |
IC 50
AMPK: 18 nM (EC50)
ASP4132 Preparation Products And Raw materials
Raw materials
Preparation Products
ASP4132 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
