3-(2-CHLOROPHENYL)PROPIONIC ACID
- CAS No.
- 1643-28-3
- Chemical Name:
- 3-(2-CHLOROPHENYL)PROPIONIC ACID
- Synonyms
- 3-(2-CHLOROPHENYL)PROPANOIC ACID;RARECHEM AL BO 0376;O-CHLOROHYDROCINNAMIC ACID;3-(2-Chlorophenyl)propionic;3-(2-chlorophenyl)propanoate;2-Chlorobenzenepropionic acid;2-Chlorobenzenepropanoic acid;3-(2-Chlorophenyl)propionic aci;3-(2-CHLOROPHENYL)PROPIONIC ACID;Benzenepropanoic acid, 2-chloro-
- CBNumber:
- CB1668489
- Molecular Formula:
- C9H9ClO2
- Molecular Weight:
- 184.62
- MDL Number:
- MFCD00016547
- MOL File:
- 1643-28-3.mol
| Product description | Number | Pack Size | Price |
| 3-(2-Chlorophenyl)propanoicacid | B405105 | 2.5g | $130 |
| 3-(2-Chlorophenyl)propanoicacid | B405105 | 250mg | $45 |
| 3-(2-Chlorophenyl)propionic acid 98% | 006108 | 5g | $34 |
| 3-(2-Chlorophenyl)propionicacid | J91567 | 5g | $35 |
| 3-(2-Chlorophenyl)propionic acid 98% | 006108 | 1g | $10 |
| More product size | |||
| Melting point | 94-96°C |
|---|---|
| Boiling point | 171°C 10mm |
| Density | 1.1989 (rough estimate) |
| refractive index | 1.5242 (estimate) |
| Flash point | 171°C/10mm |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.58(at 25℃) |
| Appearance | Off-white to light brown Solid |
| BRN | 1866789 |
| CAS DataBase Reference | 1643-28-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-(2-Chlorophenyl)propionic acid(1643-28-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3-(2-CHLOROPHENYL)PROPIONIC ACID price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B405105 | 3-(2-Chlorophenyl)propanoicacid | 1643-28-3 | 2.5g | $130 | 2021-12-16 | Buy |
| TRC | B405105 | 3-(2-Chlorophenyl)propanoicacid | 1643-28-3 | 250mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 006108 | 3-(2-Chlorophenyl)propionic acid 98% | 1643-28-3 | 5g | $34 | 2021-12-16 | Buy |
| AK Scientific | J91567 | 3-(2-Chlorophenyl)propionicacid | 1643-28-3 | 5g | $35 | 2021-12-16 | Buy |
| Matrix Scientific | 006108 | 3-(2-Chlorophenyl)propionic acid 98% | 1643-28-3 | 1g | $10 | 2021-12-16 | Buy |
3-(2-CHLOROPHENYL)PROPIONIC ACID Chemical Properties,Uses,Production
Chemical Properties
White powder
Synthesis
2033-24-1
89-98-5
1643-28-3
The general procedure for the synthesis of o-chlorophenylpropionic acid (3-(2-chlorophenyl)propionic acid) from cyclic (sub)isopropyl malonate and o-chlorobenzaldehyde was as follows: to a three-necked flask equipped with a dropping funnel, a reflux condenser, and a thermometer was added 85% formic acid (8 mL, 180 mmol). After cooling the solution to 5°C, triethylamine (2.7 mL, 27 mmol) was added slowly and dropwise to ensure that the reaction temperature was maintained below 10°C. Subsequently, 2-bromobenzaldehyde (7a, 5 g, 27 mmol) and Meldrum acid (3.9 g, 27 mmol) were added to the reaction system and the mixture was heated to reflux for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into pre-cooled ice water (30 mL). The resulting suspension was acidified to pH ≈ 1 with 5.5 M hydrochloric acid and subsequently placed in a refrigerator overnight. The precipitated crystals were collected by diafiltration, washed with cold water (3 × 20 mL), dried in a desiccator and the product was dissolved in chloroform (100 mL). Insoluble impurities were removed by filtration and the filtrate was concentrated to about 10 mL, after which petroleum ether (15 mL) was added with stirring and the solution was heated. After slow cooling, a white solid was precipitated. A final 4.17 g (67% yield) of the target product was obtained with a melting point of 93-95°C (literature value 99-100°C). The proton NMR spectrum of the product was in agreement with the data reported in literature [8].
References
[1] Synthetic Communications, 1995, vol. 25, # 19, p. 3067 - 3074
[2] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 884 - 892
[3] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 3, p. 670 - 684
3-(2-CHLOROPHENYL)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13620 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21599 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 3-(2-CHLOROPHENYL)PROPIONIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 3-(2-CHLOROPHENYL)PROPIONIC ACID
1643-28-3
|
US $31.00-1.50 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2022-02-10 | 3-(2-Chlorophenyl)propanoic acid
1643-28-3
|
US $0.00 / KG | 1KG | 99.2% | 100 tons | Honest Joy Holdings Limited | |
 |
2021-07-13 | 3-(2-CHLOROPHENYL)PROPIONIC ACID
1643-28-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-(2-CHLOROPHENYL)PROPIONIC ACID
1643-28-3
- US $31.00-1.50 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-(2-Chlorophenyl)propanoic acid
1643-28-3
- US $0.00 / KG
- 99.2%
- Honest Joy Holdings Limited
-
- 3-(2-CHLOROPHENYL)PROPIONIC ACID
1643-28-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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