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5-Bromouridine

5-Bromouridine structure

CAS No.: 957-75-5

Chemical Name:: 5-Bromouridine

Synonyms: 5-BrU;5-Br-rU;5-Br-Ur;5-Br-Uridine;850187-250MG;5-bromo-uridin;5-BROMOURIDINE;5'-BROMOURIDINE;5-Bromo-D-uridine;Uridine, 5-bromo-

CBNumber:: CB1683763

Molecular Formula:: C9H11BrN2O6

Molecular Weight:: 323.1

MDL Number:: MFCD00006528

MOL File:: 957-75-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:44:00

Product description	Number	Pack Size	Price
5-Bromouridine 98%	850187	250mg	$49.7
5-Bromouridine 98%	850187	1g	$123
5-Bromouridine >99.0%(HPLC)	B0666	1g	$70
5-Bromouridine >99.0%(HPLC)	B0666	100mg	$18
5-Bromouridine ≥98%	30457	500mg	$49
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5-Bromouridine Properties

Melting point	180-182 °C (dec.) (lit.)
alpha	-11 º (c=2 in H2O)
Density	1.9322 (rough estimate)
refractive index	1.6520 (estimate)
storage temp.	-20°C
solubility	Water (Sonicated)
form	Solid
pka	7.73±0.10(Predicted)
color	Off-White
optical activity	[α]22/D 11°, c = 2 in H2O
Water Solubility	Insoluble in water.
BRN	33664
InChI	1S/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
InChIKey	AGFIRQJZCNVMCW-UAKXSSHOSA-N
SMILES	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(Br)C(=O)NC2=O
CAS DataBase Reference	957-75-5(CAS DataBase Reference)
FDA UNII	KEY8PG1BRC
UNSPSC Code	12352204
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Danger

Hazard statements

H225

Precautionary statements

P210-P403+P235

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

RTECS

YU7300000

HS Code

29349990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

5-Bromouridine price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	850187	5-Bromouridine 98%	957-75-5	250mg	$49.7	2026-04-30	Buy
Sigma-Aldrich	850187	5-Bromouridine 98%	957-75-5	1g	$123	2026-04-30	Buy
TCI Chemical	B0666	5-Bromouridine >99.0%(HPLC)	957-75-5	1g	$70	2026-04-30	Buy
TCI Chemical	B0666	5-Bromouridine >99.0%(HPLC)	957-75-5	100mg	$18	2026-04-30	Buy
Cayman Chemical	30457	5-Bromouridine ≥98%	957-75-5	500mg	$49	2026-04-30	Buy

Product number	Packaging	Price	Buy
850187	250mg	$49.7	Buy
850187	1g	$123	Buy
B0666	1g	$70	Buy
B0666	100mg	$18	Buy
30457	500mg	$49	Buy

5-Bromouridine Chemical Properties,Uses,Production

Description

5-Bromouridine is an energy-related metabolite that is a precursor of uridine. 5-Bromouridine binds to the nuclear DNA in cells, where it can act as a transcriptional regulator. 5-Bromouridine is used in the treatment of malignant brain tumors, where it can inhibit tumor growth by binding to the dna of cancer cells and preventing the synthesis of proteins required for cell division.

Chemical Properties

WHITE FINE POWDER

Uses

5-Bromouridine is a uridine (U829910) derivative and is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry.

Uses

5-Bromouridine is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry. It possesses anti-viral activity and inhibits the activity of viruses such as human immunodeficiency virus.

Definition

ChEBI: A uridine having a bromo substituent at the 5-position.

Synthesis

58-96-8

957-75-5

General method: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (5, 0.103 g, 0.4 mmol) was dissolved in aqueous acetonitrile (H2O:CH3CN = 1:9, 5 mL) under stirring conditions. Subsequently, NaN3 (0.104 g, 1.6 mmol) was added and SMBI (0.101 g, 0.44 mmol) was added at room temperature. The reaction mixture was stirred continuously and the progress of the reaction was monitored by thin layer chromatography (TLC). After 1.5 h of reaction, the reaction mixture was filtered, concentrated under reduced pressure and co-evaporated with acetonitrile (2 × 2 mL) to remove residual water. The crude product was purified by column chromatography (eluent: 4%-6% methanol in dichloromethane, v/v) to afford the pure 5-bromouridine (6, 0.117 g, 93%) as a white solid.

Purification Methods

Recrystallise it from 96% EtOH. UV max 279nm (log 3.95)in 2O pH 1.9. RF in n -BuOH/AcOH/H2O (4:4:1) is 0.49; in n-BuOH/EtOH/H2O (40:11:9) it is 0.46 and in isoPrOH/25%NH3/H2O (7:1:2) it is 0.53 using Whatman No 1 paper. [Pryst.s & Sorm Collect Czech Chem Commmun 29 2956 1964, Beilstein 31 H 24.]

References

[1] Canadian Journal of Chemistry, 1994, vol. 72, # 9, p. 2005 - 2010
[2] Synthesis, 2009, # 23, p. 3957 - 3962
[3] Journal of Organic Chemistry, 1990, vol. 55, # 16, p. 4928 - 4933
[4] Organic and Biomolecular Chemistry, 2008, vol. 6, # 16, p. 2884 - 2891
[5] Nucleosides, Nucleotides and Nucleic Acids, 2009, vol. 28, # 9, p. 821 - 834

5-Bromouridine synthesis

Synthesis of 5-Bromouridine from Guanosine

5-Bromouridine Preparation Products And Raw materials

Raw materials

beta-D-Ribofuranose 1,2,3,5-tetraacetate 2',3',5'-Tri-O-acetyluridine 5-Bromouracil Uridine N-Bromoisocyanuric acid monosodium salt

Acetonitrile Sodium azide Guanosine

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Preparation Products

(3R)-3,4,5,6-Tetrahydro-4β,5β-dihydroxy-3β,6β-epoxy-2H,8H-pyrimido[6,1-b][1,3]oxazocine-8,10(9H)-dione

5-Bromouridine Suppliers

Global( 254)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5746	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-86-15536356810 +8617392712697	1022@dideu.com	China	29066	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5994	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Alchem Pharmtech,Inc.	58
Antai Fine Chemical Technology Co.,Limited	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Wuhan Fortuna Chemical Co., Ltd	58

View Lastest Price from 5-Bromouridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-17	5-Bromouridine 957-75-5		1KG	99.0%	500kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-09	5-Bromouridine 957-75-5		1G	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2026-03-20	5-Bromouridine 957-75-5	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

5-Bromouridine
957-75-5
$0.00
99.0%
WUHAN FORTUNA CHEMICAL CO., LTD

5-Bromouridine
957-75-5
98%
Shenzhen Nexcon Pharmatechs Ltd.

5-Bromouridine
957-75-5
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Bromouridine Spectrum

5-Bromouridine(957-75-5)MS 5-Bromouridine(957-75-5)¹HNMR 5-Bromouridine(957-75-5)¹³CNMR 5-Bromouridine(957-75-5)IR1 5-Bromouridine(957-75-5)IR2 5-Bromouridine(957-75-5)Raman

957-75-5(5-Bromouridine)Related Search:

Uridine 5-Bromo-2-chloropyrimidine Floxuridine 5-Bromouracil 5-Bromopyrimidine

Ribavirin 5-Fluorocytidine 1-beta-D-Arabinofuranosyluracil Uracil Doxifluridine

Cytidine PROTOVERATRINE B 5-bromouridine-5'-monophosphate 2'-DEOXY-2'-BROMO-URIDINE Broxuridine

5-bromouridine 2',3',5'-Triacetate,2',3',5'-Triacetyl-5-bromouridine 5-BROMOURIDINE 5'-TRIPHOSPHATE SODIUM SALT 2'-O-METHYL-5-BROMO-U CEP

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1-beta-ribofuranosyl-5-bromo-uracil 5-bromo-uridin 5-Bromouridine,98% 5-Bromouridine, 99+% 5-bromouracil-1-β-d-ribofuranoside 5-Bromo-D-uridine 5-BROMO-URIDINE(5-BRU) 5-BROMOURIDINE (5-BROMOURACIL-1-β-D-RIBOFURANOSIDE: 5-BRU) 5-BROMOURIDINE extrapure 5-Bromouracil-1-β-D-ribofuranoside, 5-Bromouridine 5-Bromo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione 5-BrU 5-broMo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione 5-broMo-1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione 5-Br-rU 5-BroMo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione 5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3 5-Br-Uridine 5-BROMOURACIL-1-BETA-D-RIBOFURANOSIDE (-)-5-BROMOURIDINE 5'-BROMOURIDINE 5-BROMOURIDINE 5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1 5-Br-Ur 5-Bromouridine > Uridine, 5-bromo- 5-Bromouridine USP/EP/BP (?)-5-Bromouridine 850187-250MG 957-75-5 C9H11BrN2O6 C9H11N2O6Br Specialty Synthesis Oligonucleotide Synthesis Nucleosides Pyridines, Pyrimidines, Purines and Pteredines Biochemistry Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents