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2,4-DIMETHYL-6-HYDROXYPYRIMIDINE

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE structure

CAS No.: 6622-92-0

Chemical Name:: 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE

Synonyms: 4-Hydroxy-2,6-dimethyL;2,6-DIMETHYL-4-PYRIMIDINO;2,6-dimethlpyrimidin-4-ol;6-dimethyl pyrimidin-4-ol;2,6-DIMETHYLPYRIMIDIN-4-OL;2,6-DIMETHYL-4-PYRIMIDINOL;2,4-Dimethyl-6-pyrimidinol;2,4-Dimethylpyrimidine-6-ol;2,6-Dimethylpyrimidine-4-ol;2,6-dimethylpyrimidine-4--one

CBNumber:: CB1692244

Molecular Formula:: C6H8N2O

Molecular Weight:: 124.14

MDL Number:: MFCD00006105

MOL File:: 6622-92-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:54

Product description	Number	Pack Size	Price
2,4-Dimethyl-6-hydroxypyrimidine >98.0%(HPLC)(T)	D2579	5g	$97
2,4-Dimethyl-6-hydroxypyrimidine >98.0%(HPLC)(T)	D2579	25g	$317
2,6-Dimethyl-1H-pyrimidin-4-one	D480258	1g	$45
2,6-Dimethyl-1H-pyrimidin-4-one	D480258	10g	$75
2,4-Dimethyl-6-hydroxypyrimidine	4H01-1-W6	5G	$24
More product size

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2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Properties

Melting point	198.5-200 °C (lit.)
Boiling point	230.92°C (rough estimate)
Density	1.1683 (rough estimate)
refractive index	1.5378 (estimate)
storage temp.	Inert atmosphere,Room Temperature
pka	9.87±0.50(Predicted)
form	Crystalline Needles
color	White
BRN	114324
InChI	InChI=1S/C6H8N2O/c1-4-3-6(9)8-5(2)7-4/h3H,1-2H3,(H,7,8,9)
InChIKey	UQFHLJKWYIJISA-UHFFFAOYSA-N
SMILES	C1(C)=NC(C)=CC(=O)N1
CAS DataBase Reference	6622-92-0(CAS DataBase Reference)
FDA UNII	M26W21396B
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

29335995

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
1		0

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D2579	2,4-Dimethyl-6-hydroxypyrimidine >98.0%(HPLC)(T)	6622-92-0	5g	$97	2025-07-31	Buy
TCI Chemical	D2579	2,4-Dimethyl-6-hydroxypyrimidine >98.0%(HPLC)(T)	6622-92-0	25g	$317	2025-07-31	Buy
TRC	D480258	2,6-Dimethyl-1H-pyrimidin-4-one	6622-92-0	1g	$45	2021-12-16	Buy
TRC	D480258	2,6-Dimethyl-1H-pyrimidin-4-one	6622-92-0	10g	$75	2021-12-16	Buy
SynQuest Laboratories	4H01-1-W6	2,4-Dimethyl-6-hydroxypyrimidine	6622-92-0	5G	$24	2021-12-16	Buy

Product number	Packaging	Price	Buy
D2579	5g	$97	Buy
D2579	25g	$317	Buy
D480258	1g	$45	Buy
D480258	10g	$75	Buy
4H01-1-W6	5G	$24	Buy

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Chemical Properties,Uses,Production

Chemical Properties

white crystalline needles

Synthesis

124-42-5

141-97-9

6622-92-0

General procedure for the synthesis of 2,4-dimethyl-6-hydroxypyrimidines from acetamidine hydrochloride and ethyl acetoacetate: to a solution of sodium ethanolate (10.5 g, 154 mmol) in ethanol (200 mL) was added ethyl 3-oxobutanoate (10.0 g, 77 mmol) and acetamidine hydrochloride (7.23 g, 77 mmol) sequentially. The reaction mixture was heated to reflux for 20 hours. After completion of the reaction, water (10 mL) was added to the mixture. The reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel as stationary phase, dichloromethane/methanol=15:1 as mobile phase) to afford 2,6-dimethylpyrimidin-4-ol as a yellow solid (3.43 g, 36% yield).LRMS (M+H+) m/z: Calculated value 124.06; measured value 124.

References

[1] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 00374; 00375
[2] Synthesis (Germany), 2016, vol. 48, # 23, p. 4246 - 4252
[3] Patent: US2012/95031, 2012, A1. Location in patent: Page/Page column 159-160

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE synthesis

Synthesis of 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE from Acetamidine hydrochloride and Ethyl acetoacetate

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

Acetamidine Base Ethanol Sodium ethoxide Ethyl acetoacetate Acetamidine hydrochloride

Ethyl diacetoacetate

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Preparation Products

4-CHLORO-2,6-DIMETHYLPYRIMIDINE 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE 5-Bromo-4-hydrazinyl-2,6-dimethylpyrimidine 5-Bromo-4-chloro-2,6-dimethylpyrimidine

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Suppliers

Global( 211)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Shanghai Rlavie Technology Co ltd	+86-021-67759270 +8617717059219	sales@rlavie.com	China	1030	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30228	58

Supplier	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Shanghai Rlavie Technology Co ltd	58
Career Henan Chemica Co	58

View Lastest Price from 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2,4-DIMETHYL-6-HYDROXYPYRIMIDINE 6622-92-0	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2022-09-12	2,4-Dimethyl-6-hydroxypyrimidine 6622-92-0	US $0.00-0.00 / G	1G	98%min	50kg/month	Shanghai Rlavie Technology Co ltd
2019-07-06	2,4-DIMETHYL-6-HYDROXYPYRIMIDINE 6622-92-0	US $8.00 / kg	1kg	99%	10tons	Career Henan Chemical Co

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
6622-92-0
US $1.10 / g
99.00%
Dideu Industries Group Limited

2,4-Dimethyl-6-hydroxypyrimidine
6622-92-0
US $0.00-0.00 / G
98%min
Shanghai Rlavie Technology Co ltd

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
6622-92-0
US $8.00 / kg
99%
Career Henan Chemical Co

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Spectrum

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)MS 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)¹HNMR 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)¹³CNMR 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)IR1 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)IR2 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE(6622-92-0)Raman

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6-HYDROXY-2,4-DIMETHYLPYRIMIDINE 4-HYDROXY-2,6-DIMETHYLPYRIMIDINE 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE 2,6-DIMETHYLPYRIMIDIN-4-OL 2,6-DIMETHYL-4-PYRIMIDINO 2,6-DIMETHYL-4-PYRIMIDINOL 2,6-DIMETHYL-4-HYDROXYPYRIMIDINE 2,6-Dimethyl-4(3H)-pyrimidinone 2,6-dimethyl-1,4-dihydropyrimidin-4-one 2,6-Dimethyl-4-pyrimidinol 6-Hydroxy-2,4-dimethylpyrimidine 2,6-DiMethylpyriMidin-4(3H)-One hydroxy-2,6-diMethylpyriMidine 2,4-Dimethyl-6-hydroxypyrimidine, 2,6-Dimethyl-4-pyrimidinol 2,4-Dimethylpyrimidine-6-ol 2,6-Dimethylpyrimidin-4(1H)-one 2,6-Dimethylpyrimidine-4(3H)-one 2,6-Dimethylpyrimidine-4-ol 2,6-Dimethylpyrimidin-4-ol, 2,4-Dimethyl-6-hydroxy-1,3-diazine 2,4-Dimethyl-6-pyrimidinol 6-hydroxy-2,4-dimethylyrimidine 2,6-dimethyl-1H-pyrimidin-4-one 4-Hydroxy-2,6-dimethylpyrimidine, >=99% 4(1H)-Pyrimidinone, 2,6-dimethyl- (8CI,9CI) 2,4-Dimethyl-6-hydroxypyrimidine, 99+% 2,4-Dimethyl-6-hydroxypyrimidine> 4-Hydroxy-2,6-dimethyL 4(3H)-Pyrimidinone, 2,6-dimethyl- 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE ISO 9001：2015 REACH 2,6-dimethylpyrimidine-4--one 2,6-Dimethyl-4(1H)-pyrimidinone 2,6-dimethlpyrimidin-4-ol 6-dimethyl pyrimidin-4-ol 2,6-dimethyl-4(3H)-pyrimidineone 6622-92-0 412003-95-4 Building Blocks Heterocyclic Building Blocks Pyrimidines alcohol PYRIMIDINE APIs & Intermediate