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ChemicalBook >> CAS DataBase List >>4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Structure
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid structure
CAS No.
175281-76-2
Chemical Name:
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
Synonyms
RMA-280;4-(4-(1-Hydroxyethyl);HYDROXYETHYL PHOTOLINKER;-2-methoxy-5-nitrophenoxy);HYDROXYETHYL PHOTOLINKER 1 G;Hydroxyethyl photolinker Novabiochem;4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophen;4-(4-(1-HYDROXYETHYL)-2-METHOXY-5-NITRO-PHENOXY)BUTYRIC ACID;4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY)BUTANOIC ACID;4-[4-(1-Hydroxyethyl)-2-methoxy-6-nitrophenoxy]butanoic Acid
CBNumber:
CB1699531
Molecular Formula:
C13H17NO7
Molecular Weight:
299.28
MDL Number:
MFCD01318869
MOL File:
175281-76-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:44:24
Product description Number Pack Size Price
4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid ≥98.0% (HPLC) 55262 1g $957
4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid ≥98%(HPLC) 10620 100MG $80
4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid ≥98%(HPLC) 10620 250MG $150
4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoic acid RL-2150 250mg $144
4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid ≥98%(HPLC) 10620 1G $350
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4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Properties

Melting point 163-166 °C
Boiling point 540.1±50.0 °C(Predicted)
Density 1.333±0.06 g/cm3(Predicted)
storage temp. Store below +30°C.
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka 4.54±0.10(Predicted)
color Yellow
optical activity 0.3°(C=0.01g/ml DMF)
BRN 7717635
InChI 1S/C13H17NO7/c1-8(15)9-6-11(20-2)12(7-10(9)14(18)19)21-5-3-4-13(16)17/h6-8,15H,3-5H2,1-2H3,(H,16,17)
InChIKey DUIJUTBRRZCWRD-UHFFFAOYSA-N
SMILES COc1cc(C(C)O)c(cc1OCCCC(O)=O)[N+]([O-])=O
UNSPSC Code 12352106
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
F  8-10
HS Code  2918 99 90
Storage Class 11 - Combustible Solids

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 55262 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid ≥98.0% (HPLC) 175281-76-2 1g $957 2026-04-30 Buy
Chem-Impex 10620 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid ≥98%(HPLC) 175281-76-2 100MG $80 2026-05-19 Buy
Chem-Impex 10620 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid ≥98%(HPLC) 175281-76-2 250MG $150 2026-05-19 Buy
Iris Biotech GmbH RL-2150 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 175281-76-2 250mg $144 2026-05-19 Buy
Chem-Impex 10620 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid ≥98%(HPLC) 175281-76-2 1G $350 2026-05-19 Buy
Product number Packaging Price Buy
55262 1g $957 Buy
10620 100MG $80 Buy
10620 250MG $150 Buy
RL-2150 250mg $144 Buy
10620 1G $350 Buy

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

It is used as a photolabile linker for the preparation of carboxylic acids.

Uses

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid is used for preparation of photolabile linking groups for use in solid phase synthesis.

reaction suitability

reagent type: cross-linking reagent

Synthesis

Butanoic acid, 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]-, ethyl ester

1073426-06-8

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid

175281-76-2

General procedure for the synthesis of 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid from ethyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate: ethyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate (8.53 g) was dissolved in a mixture of trifluoroacetic acid (10 mL) and water ( 100 mL) in a mixed solvent, heated to 80 °C and maintained for 18 hours. The progress of the reaction was monitored by 1H NMR and the conversion was found to be incomplete. Subsequently, additional trifluoroacetic acid (5 mL) was added and the reaction was continued for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and a solid precipitate was precipitated, which was collected by filtration. Finally, the resulting solid was freeze-dried to afford the target product 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid (8.53 g, 86% yield) as a yellow powder.1H NMR (δ, ppm, acetone-d6): 1.53 (d, CHCH3), 2.12 (p, ArOCH2CH2CH2), 2.55 (t , ArOCH2CH2CH2), 4.03 (s, ArOCH3), 4.16 (m, ArOCH2), 5.47 (q, CHCH3), 7.47 (d, neighboring aromatic H of ArOCH2), 7.59 (s, neighboring aromatic H of ArOCH3).

References

[1] Patent: US8343710, 2013, B1. Location in patent: Page/Page column 14; 16
[2] Patent: WO2018/57941, 2018, A1. Location in patent: Page/Page column 39; 43; 44
[3] Soft Matter, 2011, vol. 7, # 10, p. 4881 - 4887
[4] Patent: WO2014/197991, 2014, A1. Location in patent: Paragraph 00199-00200
[5] Patent: US2016/370376, 2016, A1. Location in patent: Paragraph 0120

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]-, ethyl ester Butanoic acid, 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]-, methyl ester

Preparation Products

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Suppliers

Global( 100)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9539 58
Henan Alfa Chemical Co., Ltd 		+8615838112936 sale03@alfachem.cn China 9798 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
PNP Biotech Co. Ltd 		+8618516098983 sales@pnpbiotech.com China 1001 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Finetech Industry Limited 		58
Henan Alfa Chemical Co., Ltd 		58
Nextpeptide Inc 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
PNP Biotech Co. Ltd 		58
Aladdin Scientific 		58

View Lastest Price from 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic Acid pictures 2024-03-28 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic Acid
175281-76-2
 25KG 97% PNP Biotech Co. Ltd
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid pictures 2020-01-14 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
175281-76-2
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Spectrum

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid(175281-76-2)1HNMR

175281-76-2(4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid)Related Search:

Hydroxyethyl-Photolinker NovaSyn TG resin HYDROXYETHYL-PHOTOLINKER NOVASYN(R) TG RESIN HYDROXYETHYL-PHOTOLINKER AM RESIN 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid 4-(4-HYDROXYMETHYL-2-METHOXY-5-NITROPHENOXY)BUTYRIC ACID
4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL

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HYDROXYETHYL PHOTOLINKER 4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY)BUTANOIC ACID 4-(4-(1-HYDROXYETHYL)-2-METHOXY-5-NITRO-PHENOXY)BUTYRIC ACID 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophen -2-methoxy-5-nitrophenoxy) 4-(4-(1-Hydroxyethyl) 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid≥ 98% (HPLC) Hydroxyethyl photolinker Novabiochem 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butyric acid >=98.0% (HPLC) HYDROXYETHYL PHOTOLINKER 1 G Butanoic acid, 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]- 4-[4-(1-Hydroxyethyl)-2-methoxy-6-nitrophenoxy]butanoic Acid 4-(4-(1-Hydroxyethyl)-2-Methoxy-5-Nitro-Phenoxy)Butylic Acid RMA-280 175281-76-2 C13H17NO7 Linkers Peptide Synthesis Specialty Synthesis Bifunctional Crosslinkers Aromatics