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NADH, disodium salt

NADH, disodium salt Structure
NADH, disodium salt structure
CAS No.
606-68-8
Chemical Name:
NADH, disodium salt
Synonyms
Β-NADH;NADH-NA2;NADH 2Na;BETA-NADH 2NA;NADH DISODIUM SALT;NADH (sodium salt);beta-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED;BETA-NICOTINAMIDE-ADENINE DINUCLEOTIDE, REDUCED, 2NA;eta-d-ribofuranosyl-3-pyridinecarboxamide,disodiumsalt;BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED DISODIUM SALT
CBNumber:
CB1709159
Molecular Formula:
C21H27N7Na2O14P2
Molecular Weight:
709.4
MDL Number:
MFCD00036200
MOL File:
606-68-8.mol
MSDS File:
SDS
Last updated:2026-01-30 08:55:53
Product description Number Pack Size Price
β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof25-30?mg(pervial) N9535 15vials $556
β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%, pkg of 5?mg (per vial) N9410 15VIALS $289
β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof2?mg(pervial) N7410 15vials $227.92
β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof10?mg(pervial) N6785 10vials $253.11
β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof0.2?mg(pervial) N6660 15vials $159.03
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NADH, disodium salt Properties

Melting point 140-142°C
Density 1.955 at 20℃
vapor pressure 0.73Pa at 20-50℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility H2O: 50 mg/mL, clear to nearly clear, yellow
form Powder
color Yellow
PH 7.5 (100mg/mL in water, ±0.5)
Water Solubility soluble
λmax 260 and 340 nm
BRN 5230241
Stability Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT
InChIKey QRGNQKGQENGQSE-WUEGHLCSSA-L
SMILES [Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
LogP -1.96 at 21℃ and pH7
Surface tension 69.22mN/m at 1.022g/L and 20℃
CAS DataBase Reference 606-68-8
FDA UNII 8295030YNC
EPA Substance Registry System Reduced .beta.-nicotinamide adenine dinucleotide disodium salt (606-68-8)
UNSPSC Code 41106305
NACRES NB.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn
Risk Statements  23/24/25-36/37/38-39/23/24/25-40-22
Safety Statements  26-36/37/39-45-24/25-36/37
WGK Germany  3
F  3-10-23
TSCA  TSCA listed
HS Code  29349990
Storage Class 11 - Combustible Solids

NADH, disodium salt price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N9535 β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof25-30?mg(pervial) 606-68-8 15vials $556 2025-07-31 Buy
Sigma-Aldrich N9410 β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%, pkg of 5?mg (per vial) 606-68-8 15VIALS $289 2025-07-31 Buy
Sigma-Aldrich N7410 β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof2?mg(pervial) 606-68-8 15vials $227.92 2025-07-31 Buy
Sigma-Aldrich N6785 β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof10?mg(pervial) 606-68-8 10vials $253.11 2025-07-31 Buy
Sigma-Aldrich N6660 β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%,pkgof0.2?mg(pervial) 606-68-8 15vials $159.03 2025-07-31 Buy
Product number Packaging Price Buy
N9535 15vials $556 Buy
N9410 15VIALS $289 Buy
N7410 15vials $227.92 Buy
N6785 10vials $253.11 Buy
N6660 15vials $159.03 Buy

NADH, disodium salt Chemical Properties,Uses,Production

Description

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

Chemical Properties

White to beige powder

Uses

One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configuration of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive.

Uses

β-Nicotinamide adenine dinucleotide, reduced disodium salt has been used in the preparation of standard curve.

Definition

NADH, disodium salt is a dehydrogenase complex that is the reduced formof NAD. As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Biological Functions

NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.

General Description

β-Nicotinamide adenine dinucleotide (β-NAD) regulates energy metabolism and immunity. It is a cofactor for mitochondrial deacetylase sirtuin-3 enzyme and modulates inflammasome assembly. β-NAD supresses interleukin-1β levels in monocytic cells in inflammatory syndromes. β-NAD released by neurosecretory cells is a potential neurotransmitter. β-NAD is a vascular mediator in lung endothelial cells and may play a protective role against cytokine mediated inflammation.

Biochem/physiol Actions

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.

Biotechnological Applications

Reduced β-nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier. NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation. NADH is a required oxidizing cosubstrate in fermentation, which regenerates NAD. NADH is fluorescent, which provides for a relatively simple way to detect NADH in biological samples. NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues.

in vitro

NADH is unstable under acidic conditions but it is stable under alkaline conditions.
NADH (0-1 mM; 0-12 h) increases NAD levels in various mammalian cell lines+.
NADH (1 mM; 24 h) causes low toxicity and protects cells from genotoxicity.

in vivo

NADH (5 μmol/mouse; i.p.; once) increases urinary excretion of nicotinamide and its metabolites in mice.
NADH (500 mg/kg; i.g.; once) promotes alcohol metabolism and prevents or ameliorates early liver injury caused by acute alcohol exposure in ethanol-loaded mice.
NADH (1000 mg/kg; i.p.; once) enhances tissue NAD levels in male C57BL/6J mice+.
NADH, disodium salt

Purification Methods

This coenzyme is available in high purity, and it is advisable to buy a fresh preparation rather than to purify an old sample as purification will invariably lead to a more impure sample contaminated with the oxidised form (NAD). It has UV max at 340nm ( 6,200 M-1cm-1) at which wavelength the oxidised form NAD has no absorption. At 340nm a 0.161mM solution in a 1cm (pathlength) cell has an absorbance of 1.0 unit. The purity is best checked by the ratio A280nm/A340nm ~2.1, a value which increases as oxidation proceeds. The dry powder is stable indefinitely at -20o. Solutions in aqueous buffers at pH ~7 are stable for extended periods at -20o and for at least 8hours at 0o, but are oxidised more rapidly at 4o in a cold room (e.g. almost completely oxidised overnight at 4o). [UV: Drabkin J Biol Chem 175 563 1945, Fluorescence: Boyer & Thorell Acta Chem Scand 10 447 1956, Redox: Rodkey J Biol Chem 234 188 1959, Schlenk in The Enzymes 2 250, 268 1951, Kaplan in The Enzymes 3 105, 112 1960.] Deuterated NADH, i.e. NADD, has been purified through the anion exchange resin AG-1 x 8 (100-200 mesh, formate form) and through a Bio-Gel P-2 column. [Viola et al. Anal Biochem 96 334 1979, Beilstein 26 III/IV 3639.]

Definition

The NAD+ Is the oxidized form, that is, a state in which it loses an electron. NADH is a reduced form of the molecule, which means that it gains the electron lost by NAD+. Redox reactions involving electron transfers play a central role in energy creation. When NAD+ takes an electron from glucose, it becomes NADH. NADH transports this electron to mitochondria where the cell can take the energy that is stored in the electron. NADH then donates the electron to oxygen, converting it back to NAD+.

References

[2]. Kimura N, et al. Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):142-8. [Content Brief]
[3]. Wu K, et al. NADH and NRH as potential dietary supplements or pharmacological agents for early liver injury caused by acute alcohol exposure. Journal of Functional Foods, 2021, 87: 104852.

NADH, disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

NADH, disodium salt Suppliers

Global( 704)Suppliers
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Supplier Advantage
Maintain Biotech Co., Ltd. 		58
Xi'an Kono chem co., Ltd.,
58
Wuhan Aoliqisi New Material Technology Co., Ltd.
58
SyncoZymes (Shanghai) Co., Ltd.,
58
Shaanxi LonierHerb Bio Technology Co Ltd
58
GIHI CHEMICALS CO.,LIMITED
58
Zibo Hangyu Biotechnology Development Co., Ltd
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WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)
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HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
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Related articles

  • Application of NADH, disodium salt
  • NADH, disodium salt is an important reducing coenzyme that acts as a regenerative electron donor in cellular energy metabolism....
  • Apr 12，2024

Related Qustion

Ask a question
Q:What is benefits and side effects of β-Nicotinamide adenine dinucleotide(NADH)?Zora - Nov 7，2025
A:β-Nicotinamide adenine dinucleotide(NADH) is a universal coenzyme central to cellular metabolism. Via its donor and acceptor function of electrons, it is critically involved in redox reactions throughout all eukaryotic cells, acting on various enzymes, including sirtuins and poly ADP-ribose polymerase 1. NADH is possibly safe for most people when used for up to 12 weeks. It's usually well-tolerated.

View Lastest Price from NADH, disodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
beta-Nicotinamide adenine dinucleotide disodium salt/NADH pictures 2026-02-13 beta-Nicotinamide adenine dinucleotide disodium salt/NADH
606-68-8
 US $0.00 / Kg/Bag 10g 95%min HPLC 10KGS WUHAN FORTUNA CHEMICAL CO., LTD
β-NADH pictures 2026-02-13 β-NADH
606-68-8
 US $0.00-0.00 / kg 1kg 99% 100KG Watson Biotechnology Co.,Ltd
NADH, disodium salt pictures 2026-02-11 NADH, disodium salt
606-68-8
 US $999.00-800.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
  • β-NADH pictures
  • β-NADH
    606-68-8
  • US $0.00-0.00 / kg
  • 99%
  • Watson Biotechnology Co.,Ltd

NADH, disodium salt Spectrum

NADH, disodium salt(606-68-8)MSNADH, disodium salt(606-68-8)1HNMR

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eta-d-ribofuranosyl-3-pyridinecarboxamide,disodiumsalt BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE, REDUCED FORM DISODIUM SALT BETA-NICOTINAMIDE-ADENINE DINUCLEOTIDE, REDUCED, 2NA BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED DISODIUM SALT BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE, DISODIUM SALT beta-Nicotinamide adenine dinucleotidedisodium salthydrate eta-d-ribofuranosyl-3-pyridinecarboxamide, disodium salt beta-nicotinamide adenine dinucleotide, disodium salt, hydrate beta-nicotinamide adenine dinucleotide disodium salt,trihydrate NICOTINAMIDE ADENINE DINUCLEOTIDE (REDUCED) DISODIUM SALT extrapure NICOTINAMIDE ADENINE DINUCLEOTIDE >98% (REDUCED FORM) DISODIUM SALT NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM SALT Nadide sodium b-Nicotinamide adenine dinucleotide reduced form disodium salt β-Nicotinamide adenine dinucleotide, reduced hydrate disodium salt Disodium 1-[(2R,3R,4R,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-3,4-dihydroxy-oxolan-2-yl]pyridine-5-carboxamide Beta-nicotinamide adenine dinucleotide, disodium salt, hydrate, 98%, reduced form 1-[5-O-[(5'-Adenylyloxy)(sodiooxy)phosphinyl]-β-D-ribofuranosyl]-1,4-dihydro-3-pyridinecarboxamide sodium salt β-DPNH, β-NADH, Coenzyme I reduced disodium salt, Diphosphopyridine nucleotide reduced disodium salt beta-Nicotinamide adenine dinucleotide disodium salt, reduced, trihydrate,98% Adenosine 5'-(Trihydrogen diphosphate) P'→5'-ester 1,4-Dihydro- 1-β-D-ribofuranosylnicotinaMide SodiuM Salt Codehydrase I Reduced Codehydrogenase I Reduced CoenzyMe I Reduced CozyMase I Reduced Dihydrocodehydrogenase I DihydrocozyMase DisodiuM DihydronicotinaMide Adenine Dinucleotide DisodiuM ENADA N 8129 NADH2 Reduced Codehydrogenase I Reduced Diphosphopyridine Nucleotide Reduced NcotinaMide Adenine Diphosphate Coenzyme I Disodium Salt Cozymase Disodium Salt beta-Diphosphopyridine Nucleotide Disodium Salt beta-DPNH Disodium Salt beta-NADH Disodium Salt NADH disodiuM salt, trihydrate, reduced NADH DISODIUM SALT N A D H, REDUCED FORM, DISODIUM NADH-NA2 NICOTINAMIDE-ADENINE DINUCLEOTIDE (REDUCED) DISODIUM SALT NICOTINAMIDE ADENINE DINUCLEOTIDE (REDUCED FORM) DISODIUM SALT NICOTINAMIDE-ADENINE DINUCLEOTIDE (REDUCED) DISODIUM SALT(NADH 2Na) NADH,NADH DISODIUM SALT Nicotinamide adenine dinucleotide >98% (reduced form) disodium salt nutraceutical grade NADH (b-NicotinaMide adenine dinucleotide,reduced β-NicotinaMide adenine dinucleotide,disodiuM salt, reduced b-NicotinaMide-adenine Dinucleotide, reduced Diphosphopyridine nucleotide, reduced form eotide, reduced disodium saL t hydrate β-Nicotinamide adenine dinucL beta-Nicotinamide adenine dinucleotide disodium salt:NADH NADH,disodiumsalthydrate β-Nicotinamide adenine dinucleotide NADH (reduced form) beta-nicotinamide adenine dinucleotide disodium BETA-NADH 2NA BETA-NADH DISODIUM BETA-NADH DISODIUM SALT BETA-DPNH DISODIUM SALT BETA-DIPHOSPHOPYRIDINE NUCLEOTIDE DISODIUM SALT, REDUCED FORM