1-PHENYLPIPERIDINE-4-CARBALDEHYDE
- CAS No.
- 111153-74-3
- Chemical Name:
- 1-PHENYLPIPERIDINE-4-CARBALDEHYDE
- Synonyms
- 4-formyl-1-phenylpiperidine;1-PHENYLPIPERIDINE-4-CARBALDEHYDE;1-Phenyl-4-piperidinecarbaldehyde;4-Piperidinecarboxaldehyde, 1-phenyl-
- CBNumber:
- CB1718115
- Molecular Formula:
- C12H15NO
- Molecular Weight:
- 189.25
- MDL Number:
- MFCD06410645
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
1-PHENYLPIPERIDINE-4-CARBALDEHYDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM0135530 | 1-PHENYLPIPERIDINE-4-CARBALDEHYDE 95.00% | 111153-74-3 | 1G | $1819.13 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0135530 | 1-PHENYLPIPERIDINE-4-CARBALDEHYDE 95.00% | 111153-74-3 | 5G | $2152.64 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0135530 | 1-PHENYLPIPERIDINE-4-CARBALDEHYDE 95.00% | 111153-74-3 | 10G | $3668.57 | 2021-12-16 | Buy |
| Alichem | 111153743 | 1-Phenylpiperidine-4-carbaldehyde | 111153-74-3 | 25g | $4971.4 | 2021-12-16 | Buy |
| Alichem | 111153743 | 1-Phenylpiperidine-4-carbaldehyde | 111153-74-3 | 10g | $2580.84 | 2021-12-16 | Buy |
1-PHENYLPIPERIDINE-4-CARBALDEHYDE Chemical Properties,Uses,Production
Uses
1-Phenylpiperidine-4-carbaldehyde is a useful reagent in the preparation of 2-?phenylthiazolidine derivatives used as cardiotonic agents.
Synthesis
697306-45-9
111153-74-3
General procedure for the synthesis of 1-phenylpiperidine-4-carbaldehyde from (1-phenyl-4-piperidinyl)methanol: (1-phenyl-4-piperidinyl)methanol (0.81 g, 4.23 mmol) and 1,8-diazabicyclohexadec-7-ene (DBU, 1.29 g, 8.46 mmol) were dissolved in anhydrous dichloromethane (17 mL) and the mixture was cooled to - 78 °C. A solution of N-tert-butylphenylsulfinimidyl chloride (1.0 g) in dichloromethane (5 mL) was slowly added with stirring, keeping the reaction temperature below -60 °C and stirring continuously for 1 hour. Upon completion of the reaction, water was added to the reaction mixture and extracted with ether. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO?), filtered and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (4:1, v/v) to afford 1-phenylpiperidine-4-carbaldehyde (720 mg, 90% yield).1H NMR (400 MHz, CDCl?) δ ppm: 1.75-1.85 (m, 2H), 2.00-2.06 (m, 2H), 2.36-2.46 (m, 1H), 2.83-2.90 (m, 2H), 3.61 (t, J = 3.8 Hz, 1H), 3.64 (t, J = 3.8 Hz, 1H), 6.84-6.96 (m, 3H), 7.23-7.29 (m, 2H), 9.71 (s, 1H).
References
[1] Patent: WO2004/46107, 2004, A1. Location in patent: Page 227-228
1-PHENYLPIPERIDINE-4-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-PHENYLPIPERIDINE-4-CARBALDEHYDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Qinghang Chemical Co. Ltd. | 021-50840321, 18601625411 | thomasleehz@hotmail.com | China | 216 | 50 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 18626450290 | yftan@aikonchem.com | China | 16679 | 50 |
| BioPharmaMatrix,Inc. | 0510-86010668 | sales@biopharmamatrix.com | China | 4702 | 55 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9967 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39665 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
