N-Methyl-D-prolinol
- CAS No.
- 99494-01-6
- Chemical Name:
- N-Methyl-D-prolinol
- Synonyms
- -D-proL;1-Methyl-D-prolinol;N-METHYL-D-PROLINOL;N-Methyl-D-Prolinol,>98%;N-Methyl-D-prolinol USP/EP/BP;(R)-1-METHYL-2-PYRROLIDINEMETHANOL;(R)-N-methylpyrrolidine-2-methanol;(?-1-Methylpyrrolidin-2-yl)methanol;((R)-1-methylpyrrolidin-2-yl)methanol;[(2R)-1-methyl-2-pyrrolidinyl]methanol
- CBNumber:
- CB1728183
- Molecular Formula:
- C6H13NO
- Molecular Weight:
- 115.17
- MDL Number:
- MFCD07368622
- MOL File:
- 99494-01-6.mol
- MSDS File:
- SDS
| Density | 0.971 g/mL at 25 °C |
|---|---|
| refractive index | n20/D4.469 |
| Flash point | 71℃ |
| storage temp. | 2-8°C |
| pka | 14.77±0.10(Predicted) |
| form | liquid |
| Appearance | Colorless to light yellow Liquid |
| optical activity | Consistent with structure |
| Boiling point | 68-71°C(lit.) |
| InChI | InChI=1S/C6H13NO/c1-7-4-2-3-6(7)5-8/h6,8H,2-5H2,1H3/t6-/m1/s1 |
| InChIKey | VCOJPHPOVDIRJK-ZCFIWIBFSA-N |
| SMILES | N1(C)CCC[C@@H]1CO |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933998090 |
N-Methyl-D-prolinol price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 761990 | (R)-1-Methyl-2-pyrrolidinemethanol 97% | 99494-01-6 | 1g | $101 | 2025-07-31 | Buy |
| TRC | M327288 | N-Methyl-D-prolinol | 99494-01-6 | 50mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-W003381 | N-Methyl-D-prolinol 99.07% | 99494-01-6 | 25g | $53 | 2021-12-16 | Buy |
| Matrix Scientific | 075179 | N-Methyl-D-prolinol 95+% | 99494-01-6 | 5g | $63 | 2021-12-16 | Buy |
| Apolloscientific | OR315047 | N-Methyl-D-prolinol | 99494-01-6 | 5g | $102 | 2021-12-16 | Buy |
N-Methyl-D-prolinol Chemical Properties,Uses,Production
Uses
N-Methyl-D-prolinol is used as a pharmaceutical or synthetic intermediate component in the preparation of organic compounds such as nitrogen-containing heterocyclic compounds, pyrotinib intermediate and anidulafungin derivative.
Synthesis
59378-81-3
3554-65-2
Step 1: Preparation of [(2R)-1-methylpyrrolidin-2-yl]methanol Lithium aluminum hydride (230 mg, 6 mmol) and N-tert-butoxycarbonyl-R-prolinol (400 mg, 2 mmol) were dissolved in 10 mL of dry tetrahydrofuran and cooled in an ice water bath. After no significant gas release, the reaction mixture was heated to reflux and maintained for 2 hours. Upon completion of the reaction, the mixture was slowly added dropwise to 5 mL of methanol in an ice-water bath, followed by the addition of 5 mL of water. The mixture was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford N-methyl-D-prolinol [(2R)-1-methylpyrrolidin-2-yl]methanol (221 mg, 77.0% yield) as a colorless oil. Mass spectrum (ESI) m/z: 116 [M + 1].
References
[1] Patent: US2013/338190, 2013, A1. Location in patent: Paragraph 0037; 0038
[2] Patent: EP2684877, 2014, A2. Location in patent: Page/Page column 0032; 0033
[3] Patent: TWI524893, 2016, B. Location in patent: Page/Page column 44; 45
[4] Patent: WO2018/31877, 2018, A1. Location in patent: Paragraph 00150
N-Methyl-D-prolinol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29801 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12273 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
View Lastest Price from N-Methyl-D-prolinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | N-Methyl-D-prolinol
99494-01-6
|
US $1.00 / KG | 1IU | 99% | 100kg | Career Henan Chemical Co |
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- N-Methyl-D-prolinol
99494-01-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
