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2H-1,2,4-Triazole-3-carboxamide

2H-1,2,4-Triazole-3-carboxamide structure

CAS No.: 3641-08-5

Chemical Name:: 2H-1,2,4-Triazole-3-carboxamide

Synonyms: Ribavirin EP Impurity D;1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE;Ribavirin base;VITAS-BB TBB000340;Ribavirin Impurity 4;4-Triazole-3-carboxaMide;Ribavarin EP Impurity D;1,2,4-Triazole-3-formamide;3-formamide 1,2,4-triazole;2H-1,2,4-Triazole-3-carboxa

CBNumber:: CB1738858

Molecular Formula:: C3H4N4O

Molecular Weight:: 112.09

MDL Number:: MFCD03990481

MOL File:: 3641-08-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:46:04

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2H-1,2,4-Triazole-3-carboxamide Properties

Melting point	315 °C
Boiling point	393.4±25.0 °C(Predicted)
Density	1.537±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Aqueous Base (Slightly), DMSO (Slightly)
form	Solid
pka	8.50±0.20(Predicted)
color	White to Off-White
Major Application	pharmaceutical (small molecule)
InChI	1S/C3H4N4O/c4-2(8)3-5-1-6-7-3/h1H,(H2,4,8)(H,5,6,7)
InChIKey	ZEWJFUNFEABPGL-UHFFFAOYSA-N
SMILES	[nH]1ncnc1C(=O)N
CAS DataBase Reference	3641-08-5(CAS DataBase Reference)
FDA UNII	C405ON563A
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933999552
Storage Class	11 - Combustible Solids

2H-1,2,4-Triazole-3-carboxamide price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2779	Ribavirin Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg	3641-08-5	30MG	$539	2026-04-30	Buy
Sigma-Aldrich	1602740	Ribavirin Related Compound D United States Pharmacopeia (USP) Reference Standard	3641-08-5	15mg	$1210	2026-04-30	Buy
TCI Chemical	T2402	1,2,4-Triazole-3-carboxamide >97.0%(HPLC)(N)	3641-08-5	5g	$95	2026-04-30	Buy
TCI Chemical	T2402	1,2,4-Triazole-3-carboxamide >97.0%(HPLC)(N)	3641-08-5	25g	$286	2026-04-30	Buy
Usbiological	458703	N-Des-1-β-D-ribofuranosyl Ribavirin	3641-08-5	2.5g	$403	2026-06-03	Buy

Product number	Packaging	Price	Buy
PHR2779	30MG	$539	Buy
1602740	15mg	$1210	Buy
T2402	5g	$95	Buy
T2402	25g	$286	Buy
458703	2.5g	$403	Buy

2H-1,2,4-Triazole-3-carboxamide Chemical Properties, Uses, Production

Uses

N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Definition

ChEBI: 1,2,4-triazole-3-carboxamide is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by an aminocarbonyl group at position 3. It is the major catabolite and aglycon of ribavirin. It has a role as a human urinary metabolite and a drug metabolite. It is a member of triazoles, a primary carboxamide, a monocarboxylic acid amide and an aromatic amide.

Synthesis

515-96-8

16694-46-5

3641-08-5

GENERAL STEPS: Methylimine ethyl ester hydrochloride (34.5 g, 0.315 mol) and 100 mL of formamide were added to a 250 mL three-necked flask at room temperature, followed by the addition of sodium ethoxide (21.4 g, 0.315 mol) and stirred for 10 min. Next, 2-hydrazino-2-oxoacetamide (10.8 g, 0.105 mol) was added, and the reaction mixture was heated to 130 °C for 10 h. The reaction pressure was maintained at 10 MPa. The progress of the reaction was monitored by liquid chromatography, and the reaction was stopped after confirming the complete conversion of 2-hydrazino-2-oxoacetamide. After the reaction mixture was cooled to room temperature, the precipitated solid was collected by filtration, washed with water and dried. The final 1,2,4-triazolecarboxamide white solid 9.2 g was obtained in 78.2% yield.

References

[1] Patent: CN108794413, 2018, A. Location in patent: Page/Page column 4-6

2H-1,2,4-Triazole-3-carboxamide Preparation Products And Raw materials

Raw materials

Oxamic hydrazide Ethyl formimidate hydrochloride

Preparation Products

3-Cyano-1,2,4-triazole

2H-1,2,4-Triazole-3-carboxamide Suppliers

Global Suppliers ( 178)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9509	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Pure Chemistry Scientific Inc.	62
Sinopharm Chemical Reagent Co,Ltd.	79
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Shanghai Topbiochem Technology Co., Ltd	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
TOKYO CHEMICAL INDUSTRY CO., LTD.	80

View Latest Price from 2H-1,2,4-Triazole-3-carboxamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	2H-1,2,4-Triazole-3-carboxamide 3641-08-5	$1.10-9.90	1KG	99% min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2024-07-15	2H-1,2,4-Triazole-3-carboxamide 3641-08-5	$1.00	1KG	99%	20t	Shaanxi Dideu Medichem Co. Ltd
2020-02-01	2H-1,2,4-Triazole-3-carboxamide 3641-08-5	$3.00	1KG	98%	100KG	Career Henan Chemical Co

2H-1,2,4-Triazole-3-carboxamide
3641-08-5
$1.10-9.90
99% min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2H-1,2,4-Triazole-3-carboxamide
3641-08-5
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

2H-1,2,4-Triazole-3-carboxamide
3641-08-5
$3.00
98%
Career Henan Chemical Co

2H-1,2,4-Triazole-3-carboxamide Spectrum

2H-1,2,4-Triazole-3-carboxamide(3641-08-5)MS 2H-1,2,4-Triazole-3-carboxamide(3641-08-5)¹HNMR 2H-1,2,4-Triazole-3-carboxamide(3641-08-5)¹³CNMR 2H-1,2,4-Triazole-3-carboxamide(3641-08-5)IR1 2H-1,2,4-Triazole-3-carboxamide(3641-08-5)IR2

3641-08-5 (2H-1,2,4-Triazole-3-carboxamide) Related Search:

5-Methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide Ribavirin Rufinamide N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide N-tert-Butyl-3-(2-hydroxypropan-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide

5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide TARIBAVIRIN 1H-1,2,4-Triazole-3-carboxamide N,1-bis(4-chlorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide N-(3,4-Difluorophenyl)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-3-carboxamide

1-(4-Chlorophenyl)-5-methyl-N-(4-methylphenyl)-1H-1,2,4-triazole-3-carboxamide 1-(2,4-Difluorophenyl)-N-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide 1-(4-Chlorophenyl)-N-(4-methoxyphenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide N-(2,4-Dichlorophenyl)-1-(2,4-difluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide 1-(2,4-Difluorophenyl)-5-methyl-N-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-3-carboxamide

N-(2,4-Dichlorophenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-5-carboxamide N-(4-Fluorophenyl)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-3-carboxamide 5-Methyl-n,1-bis[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-3-carboxamide

1of4

1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID AMIDE 1,2,4-TRIAZOLE-3-CARBOXAMIDE 2H-1,2,4-Triazole-3-carboxamide 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 98.5% 1,2,4-TRIAZOLE-3-CARBOXYAMIDE 3-methylformamide-1,2,4-triazone 1H-1,2,4-Triazole-5-carboxamide VITAS-BB TBB000340 1,2,4-Triazole-3-formamide 2H-1,2,4-Triazole-5-carboxamide Ribavirin base 4-Triazole-3-carboxaMide 3-Carbamoyl-1H-1,2,4-triazole Ribavirin Related Compound D (15 mg) (1H-1,2,4-triazole-3-carboxamide) 3-Carbamoyl-1H-1,2,4-triazole, 3-(Aminocarbonyl)-1H-1,2,4-triazole Ribavirin Related CoMpound D N-Des-1-β-D-ribofuranosyl Ribavirin 2H-1,2,4-Triazole-3-carboxa Ribavarin EP Impurity D Ribavirin Impurity 4 1H-1,2,4-Triazole-3-formamide 3-formamide 1,2,4-triazole 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE (CAS:3641-08-5) Ribavirin Related Compound D (1H-1,2,4-triazole-3-carboxamide) (1602740) Ribavirin USP Related Compound D 2H-1,2,4-Triazole-3-carboxamide CAS NO.3641-08-5 N-Des-1-Beta-D-ribofuranosyl Ribavirin H-1,2,4-Triazole-3-carboxamide 2H-1,2,4-Triazole-3-carboxamide (Ribavirin Impurity) 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE Ribavirin EP Impurity D 3641-08-5 641-08-5 3641-08-05 3641-8-5 636-10-6