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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Structure
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride structure
CAS No.
30827-99-7
Chemical Name:
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
Synonyms
AEBSF;AEBSF HCL;AEBSF HYDROCHLORIDE;CS-2583;AEBSF HCI;A8456-25MG;PEFABLOC SC;PEFABLOC(R) SC;AEBSF Solution;PEFABLOC SC PLUS
CBNumber:
CB1769137
Molecular Formula:
C8H11ClFNO2S
Molecular Weight:
239.69
MDL Number:
MFCD00132962
MOL File:
30827-99-7.mol
MSDS File:
SDS
Last updated:2026-01-27 18:41:44
Product description Number Pack Size Price
Pefabloc? SC analytical standard 76307 100mg $140
Pefabloc? SC analytical standard 76307 1g $920
AEBSF,HCl≥99%byHPLC-CAS30827-99-7-Calbiochem 5.32586 250mg $267
AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal 101500 100mg $134
InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride in H?O. 5.08436 50MG $139
More product size
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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Properties

Melting point 175-177 °C
bulk density 200kg/m3
storage temp. 2-8°C
solubility H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
form Powder
color White
PH pH3.0～5.0 (10g/L, 25℃)
biological source synthetic (organic)
Water Solubility 10 g/L (20 ºC)
Sensitive Moisture Sensitive
BRN 7604627
Stability Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
InChI InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChIKey WRDABNWSWOHGMS-UHFFFAOYSA-N
SMILES S(C1C=CC(CCN)=CC=1)(=O)(=O)F.Cl
CAS DataBase Reference 30827-99-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII DHA6VL95HL
UNSPSC Code 41116107
NACRES NA.85

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  C,Xi
Risk Statements  34-36/37/38
Safety Statements  45-36/37/39-26-36
RIDADR  UN 3261
WGK Germany  3
Hazard Note  Corrosive
HazardClass  8
PackingGroup  II
HS Code  29214990
Storage Class 12 - Non Combustible Liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 0

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 76307 Pefabloc? SC analytical standard 30827-99-7 100mg $140 2025-07-31 Buy
Sigma-Aldrich 76307 Pefabloc? SC analytical standard 30827-99-7 1g $920 2025-07-31 Buy
Sigma-Aldrich 5.32586 AEBSF,HCl≥99%byHPLC-CAS30827-99-7-Calbiochem 30827-99-7 250mg $267 2025-07-31 Buy
Sigma-Aldrich 101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal 30827-99-7 100mg $134 2025-07-31 Buy
Sigma-Aldrich 5.08436 InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride in H?O. 30827-99-7 50MG $139 2025-07-31 Buy
Product number Packaging Price Buy
76307 100mg $140 Buy
76307 1g $920 Buy
5.32586 250mg $267 Buy
101500 100mg $134 Buy
5.08436 50MG $139 Buy

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties,Uses,Production

Description

AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.

Chemical Properties

white powder

Uses

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Uses

Recommended concentrations for use are 0.1-1 mM.

General Description

Pefabloc SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

Biochem/physiol Actions

Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25mM.

storage

Store at -20°C

References

[1] JAMES C. POWERS. Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases[J]. Chemical Reviews, 2002, 102 12: 4639-4750. DOI:10.1021/cr010182v
[2] V DIATCHUK. Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.[J]. The Journal of Biological Chemistry, 1997, 272 20: 13292-13301. DOI:10.1074/jbc.272.20.13292

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Suppliers

Global( 478)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Shandong Huisheng Import & Export Co., Ltd. 		+86-13176845580 da@zhongda-biotech.com China 232 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 286 58
Anhui Zhongda Biotechnology Co., Ltd 		+8615689548120 linda@zhongda-biotech.com China 193 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shandong Huisheng Import & Export Co., Ltd. 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Fluoropharm Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

View Lastest Price from 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride pictures 2026-02-02 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
30827-99-7
 US $0.00-0.00 / KG 10mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
AEBSF hydrochloride pictures 2026-01-27 AEBSF hydrochloride
30827-99-7
 US $43.00-92.00 / mg 99.81% 10g TargetMol Chemicals Inc.
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride pictures 2025-12-25 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
30827-99-7
 US $0.00 / gram 1gram 99% 10kg Zhejiang J&C Biological Technology Co.,Limited

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Spectrum

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride(30827-99-7)MS4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride(30827-99-7)1HNMR4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride(30827-99-7)FT-IR

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1of4

4-(Fluorosulphonyl)phenethylamine hydrochloride, 2-[4-(Fluorosulphonyl)phenyl]ethylamine hydrochloride, AEBSF Benzenesulfonyl fluoride, 4-(2-aMinoethyl)-, hydrochloride (1:1) 4-(2-AMinoethyl)benzenesulfonyl fluoride hydrochlorid 4-(2-Aminoethyl)-benzenesulfonyl fluoride hydrochloride (1:1) BROMOPHENOL BLUE NA SALT PROTEOMICS GR AEBSF HCI AEBSF AEBSF HCL AEBSF HYDROCHLORIDE 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE 4-(2-AMINOETHYL)BENZENESULPHONYL FLUORIDE HYDROCHLORIDE 4-(2-AMINOETHYL)-BENZENESULFONYL FLUORIDE 4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HCL 4-(2-AMINOETYL)-BENZENESULFONYL FLUORIDE HYDROCHLORIDE 4-(2-AMINOETHYL)BENZENESULFONYLFLUOR Pefabloc SC 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride AEBSF InSolution? AEBSF, Hydrochloride AEBSF Ready Made Solution 4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HYDROCHLOR Aebsf(4-(2-Aminoethyl)BenzenesulfonylFluoride)Hydrochloride 4-(2-Aminoethyl)Benzenesulphonylfluoridehydrochloride98+% AEBSF-HCl research grade Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride TIMTEC-BB SBB003219 PEFABLOC(R) SC PEFABLOC SC PEFABLOC SC PLUS AEBSF HYDROCHLORIDE (4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE) 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 98+% 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, AEBSF 4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride [for Biochemical Research] AEBSF hydrochloride,98% 4-(2-Aminoetyl)-benzen 4-(2-Aminoethyl)benz AEBSF hydrochloride (4-(2-Aminoethyl)benzenesulfonyl fluoride hy 4-(2-AMinoethyl)benzene-1-sulfonyl fluoride hydrochloride CS-2583 InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem 4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride [for Biochemical Research]> Aminoethyl Research AEBSF Hydrochloride extrapure AR, 98% AEBSF Solution AEBSF hydrochloride, serine protease inhibitor AEBSF hydrochloride, 10 mM in DMSO Pefabloc? SC (4-(2-Aminoethyl)-benzolsulfonylfluorid-hydrochloride) AEBSF, HCl ≥99% by HPLC Pefabloc? SC A8456-25MG Pefabloc? SC (4-(2-Aminoethyl)-benzolsulfonylfluorid-hydrochloride)[1248390100] 4-(2-aminoethyl)benzenesulfonylacylfluorohydrochloride 30827-99-7 C8H10FNO2SClH C8H11ClFNO2S C6H10FNO2SHCl C8H10FNO2SHCl C8H11FNO2SCl C8H10FNO2SxHCl Biochemicals and Reagents