2-CHLORO-5-FLUORO-3-NITROPYRIDINE
- CAS No.
- 136888-21-6
- Chemical Name:
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
- Synonyms
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE;2-CHLORO-3-NITRO-5-FLUOROPYRIDINE;Pyridine, 2-chloro-5-fluoro-3-nitro-;2-CHLORO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB1769379
- Molecular Formula:
- C5H2ClFN2O2
- Molecular Weight:
- 176.53
- MDL Number:
- MFCD06659490
- MOL File:
- 136888-21-6.mol
| Melting point | 48.0 to 52.0 °C |
|---|---|
| Boiling point | 246℃ |
| Density | 1.595 |
| Flash point | 103℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | -4.94±0.10(Predicted) |
| color | White to Yellow to Green |
| InChI | InChI=1S/C5H2ClFN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H |
| InChIKey | SVVZGNAZMPSGMU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(F)C=C1[N+]([O-])=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| HS Code | 2933399990 |
2-CHLORO-5-FLUORO-3-NITROPYRIDINE price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3115 | 2-Chloro-5-fluoro-3-nitropyridine >98.0%(GC) | 136888-21-6 | 1g | $267 | 2025-07-31 | Buy |
| TCI Chemical | C3115 | 2-Chloro-5-fluoro-3-nitropyridine >98.0%(GC) | 136888-21-6 | 200mg | $78 | 2025-07-31 | Buy |
| TRC | C585753 | 2-Chloro-5-fluoro-3-nitropyridine | 136888-21-6 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | C585753 | 2-Chloro-5-fluoro-3-nitropyridine | 136888-21-6 | 500mg | $130 | 2021-12-16 | Buy |
| Apolloscientific | PC50086 | 2-Chloro-5-fluoro-3-nitropyridine | 136888-21-6 | 5g | $88 | 2021-12-16 | Buy |
2-CHLORO-5-FLUORO-3-NITROPYRIDINE Chemical Properties,Uses,Production
Chemical Properties
light powder
Synthesis
136888-20-5
136888-21-6
General procedure for the synthesis of 2-chloro-5-fluoro-3-nitropyridine from 2-hydroxy-3-nitro-5-fluoro-pyridine: 2-hydroxy-3-nitro-5-fluoro-pyridine (1.00 g, 5.33 mmol) was dissolved in acetonitrile (40 mL), followed by the addition of a solution of tetraethylammonium chloride (2.10 g, 12.65 mmol) in acetonitrile. After the mixture was clarified, phosphorus trichloride (1.94 g, 12.65 mmol) was added slowly and dropwise at room temperature. The reaction mixture was heated to 90°C and maintained for 24 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a yellow solid product (0.90 g, 69% yield), which was pure enough to be used directly in subsequent synthesis steps. Low resolution mass spectrometry (LRMS) showed m/z: 177 ([M+H]+).
References
[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 52
[2] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 43
[3] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 45
[4] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 2, p. 287 - 293
[5] Patent: US2004/110785, 2004, A1. Location in patent: Page 77
2-CHLORO-5-FLUORO-3-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 2-CHLORO-5-FLUORO-3-NITROPYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
136888-21-6
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-08-29 | 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
136888-21-6
|
US $1.00-2.00 / KG | 1KG | 95%-99% | 100kg | Career Henan Chemical Co |
-
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
136888-21-6
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
136888-21-6
- US $1.00-2.00 / KG
- 95%-99%
- Career Henan Chemical Co
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