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6-Fluoroindole

6-Fluoroindole structure

CAS No.: 399-51-9

Chemical Name:: 6-Fluoroindole

Synonyms: 6-FLUORO-1H-INDOLE;6-FL;uoroindoL;NSC 520436;6-FLUOROINDOLE;6-Fluro-1H-indole;BUTTPARK 24\07-34;6-Fluoroindole98%;6-Fluoroindole>6-Fluoroindole 98%

CBNumber:: CB1772999

Molecular Formula:: C8H6FN

Molecular Weight:: 135.14

MDL Number:: MFCD00056933

MOL File:: 399-51-9.mol

MSDS File:: SDS

Last updated:2026-05-27 23:45:02

Product description	Number	Pack Size	Price
6-Fluoroindole 98%	349593	5g	$82.4
6-Fluoroindole 98%	349593	1g	$42.5
6-Fluoroindole >98.0%(GC)	F0352	1g	$34
6-Fluoroindole >98.0%(GC)	F0352	5g	$103
6-Fluoroindole 98+% ≥98%	234713	1g	$156
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6-Fluoroindole Properties

Melting point	72-76 °C (lit.)
Boiling point	230°C (rough estimate)
Density	1.1203 (estimate)
Flash point	>110°
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Powder
pka	16.40±0.30(Predicted)
color	Beige-brown
Water Solubility	Insoluble
Sensitive	Light Sensitive
BRN	112192
InChI	InChI=1S/C8H6FN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H
InChIKey	YYFFEPUCAKVRJX-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC(F)=C2)C=C1
CAS DataBase Reference	399-51-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

6-Fluoroindole price More Price(106)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	349593	6-Fluoroindole 98%	399-51-9	5g	$82.4	2026-04-30	Buy
Sigma-Aldrich	349593	6-Fluoroindole 98%	399-51-9	1g	$42.5	2023-06-20	Buy
TCI Chemical	F0352	6-Fluoroindole >98.0%(GC)	399-51-9	1g	$34	2026-04-30	Buy
TCI Chemical	F0352	6-Fluoroindole >98.0%(GC)	399-51-9	5g	$103	2026-04-30	Buy
Usbiological	234713	6-Fluoroindole 98+% ≥98%		1g	$156	2026-06-03	Buy

Product number	Packaging	Price	Buy
349593	5g	$82.4	Buy
349593	1g	$42.5	Buy
F0352	1g	$34	Buy
F0352	5g	$103	Buy
234713	1g	$156	Buy

6-Fluoroindole Chemical Properties,Uses,Production

Chemical Properties

beige-brown crystalline powder

Uses

6-Fluoroindole acts as a reagent in the synthesis of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, which acts as a potential anticancer immunomodulator. It is also employed as an antifungal and antibacterial agent. Further, it serves as a potent selective serotonin reuptake inhibitor. In addition to this, it is used as a inhibitor of HIV-1 attachment.

General Description

6-Fluoroindole is a halogen substituted indole. Experimental ionization potential of 6-fluoroindole has been evaluated. Preparation of 6-fluoroindole via nitration of indoline has been reported.

Synthesis

Hydrazinecarboxamide, 2-[2-(4-fluoro-2-nitrophenyl)ethylidene]-, (2E)-

1065183-63-2

399-51-9

The general procedure for the synthesis of 6-fluoroindole from the compound (CAS: 1065183-63-2) is as follows: Intermediate 110: Synthesis of 6-fluoro-1H-indole. In a 1 L high-pressure reactor, (4-fluoro-2-nitrophenyl)acetaldehyde semicarbazone (27.0 g, 0.110 mol) was suspended in THF (750 mL) with stirring. To this suspension was added a slurry of Rh/C (5 wt%) in toluene and Fe(OAc)2 (2.9 g, 0.017 mol), where the amount of Rh was 3.5 g, 0.002 mol. The reactor was charged with H2 to 50 atm and the reaction was stirred for 2 days at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with MeOH (150 mL). The filtrate was concentrated to give a black oil, which was partitioned between DCM (500 mL) and water (300 mL). The organic layer was separated and the aqueous phase was extracted with DCM (2 x 200 mL). The organic phases were combined, washed with brine (200 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was dissolved in DCM (100 mL) and decolorized by a fast silica gel column. After filtration, the filtrate was concentrated under reduced pressure to give 12.9 g (87% yield) of 6-fluoroindole. 1H NMR (300 MHz, DMSO-d6) δ: 11.11 (1H, s), 7.49 (1H, dd, J = 8.6, 5.5 Hz), 7.30 (1H, t, J = 2.4 Hz), 7.13 (1H, dd, J = 10.3, 2.4 Hz), 6.81 (1H, ddd, J = 11.0, 7.6, 2.4 Hz), 6.40-6.38 (1H, m).

References

[1] Patent: WO2008/118724, 2008, A1. Location in patent: Page/Page column 126

6-Fluoroindole synthesis

Synthesis of 6-Fluoroindole from Hydrazinecarboxamide, 2-[2-(4-fluoro-2-nitrophenyl)ethylidene]-, (2E)-

6-Fluoroindole Preparation Products And Raw materials

Raw materials

Ethenamine, 2-(4-fluoro-2-nitrophenyl)-N,N-dimethyl-, (1E)- 1H-Indole,6-fluoro-1-hydroxy-(9CI) Benzenamine, 2-ethynyl-5-fluoro- (9CI) 6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 5-Chloro-6-fluoro-1H-indole

Hydrazinecarboxamide, 2-[2-(4-fluoro-2-nitrophenyl)ethylidene]-, (2E)- Ethyl 6-fluoroindole-2-carboxylate 6-Fluoroindole-2-carboxylic acid 4-Fluoro-2-nitrotoluene N,N-Dimethylformamide dimethyl acetal

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Preparation Products

1H-Indole, 6-fluoro-4-iodo- 6-FLUOROINDOLE-3-ACETIC ACID (E)-3-(2-(1H-tetrazol-5-yl)vinyl)-6-fluoro-1H-indole 6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID Indole-6-boronic acid pinacol ester

6-Fluoro-2-oxindole

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6-Fluoroindole Suppliers

Global( 431)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
LAURENT	+8618100176782	sun@laurentpeg.com	China	365	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
career henan chemical co	58
LAURENT	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
Win-Win Chemical CO., Limited	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
HaBo Hong Kong Co., Limited.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 6-Fluoroindole manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	6-Fluoroindole 399-51-9	5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2026-02-02	1-Methyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine dihydrochloride 399-51-9	5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2026-01-29	6-Fluoroindole 399-51-9	1g	98%	30kg	LAURENT

6-Fluoroindole
399-51-9
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

1-Methyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine dihydrochloride
399-51-9
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

6-Fluoroindole
399-51-9
98%
LAURENT

6-Fluoroindole Spectrum

6-Fluoroindole(399-51-9)¹HNMR 6-Fluoroindole(399-51-9)IR

399-51-9(6-Fluoroindole)Related Search:

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6-FLUOROINDOLE-3-CARBOXALDEHYDE 98% (HPLC),6-FLUOROINDOLE-3-ALDEHYDE,6-FLUOROINDOLE-3-CARBALDEHYDE,6-FLUOROINDOLE-3-CARBOXALDEHYDE 5-Fluoro-2,3-dimethyl-1H-indole 5-Fluoroindoline 6-Fluoro-2-oxindole 4,6-DIFLUOROOXINDOLE

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6-FLUORO-2-IODOBENZALDEHYDE 6-Fluoroindole in stock Factory 6-FL uoroindoL 6-FLUOROINDOLE FOR SYNTHESIS 25 G 6-FLUOROINDOLE FOR SYNTHESIS 5 G 6-Fluoroindole ,97% 6-Fluoroindole,6-Fluoro-1H-indole 6-Fluro-1H-indole 6 - fluorine indole NSC 520436 6-Fluoroindole 98% 6-FLUOROINDOLE 1H-INDOLE, 6-FLUORO- BUTTPARK 24\07-34 6-Fluoroindole98% 6-Fluoroindole> 6-FLUORO-1H-INDOLE 399-51-9 339-51-9 Heterocyclic Building Blocks FA - FL Alphabetic Indoles Simple Indoles Analytical Chromatography Product Catalog Building Blocks Analytical Standards Indole Series Simple Indoles Indole FA - FLBuilding Blocks Alphabetic F Heterocyclic Building Blocks Building Blocks Indoles blocks FluoroCompounds IndolesOxindoles Indole/indoline/oxindole Indole and Indoline Indoles and derivatives bc0001