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TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN structure

CAS No.: 6089-04-9

Chemical Name:: TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN

Synonyms: pent-4-ynoic acid;Pyran;2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran;PROPARGYL ALCOHOL TETRAHYDRO-2H-PYRAN ETHER;2-prop-2-ynoxytetrahydropyran;2-Propargyloxane;2-prop-2-ynoxyoxane;TIMTEC-BB SBB008982;(2S)-2-prop-2-ynoxyoxane;2-Propynyl 2-pyranyl ether

CBNumber:: CB1779468

Molecular Formula:: C8H12O2

Molecular Weight:: 140.18

MDL Number:: MFCD00006604

MOL File:: 6089-04-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:45:36

Product description	Number	Pack Size	Price
Tetrahydro-2-(2-propynyloxy)-2H-pyran 98%	300810	25g	$83.4
Tetrahydro-2-(2-propynyloxy)-2H-pyran 98%	300810	100g	$316
2-(2-Propynyloxy)tetrahydropyran >97.0%(GC)	P1624	25g	$146
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 97%	66503	5G	$59
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 97%	66503	25G	$116
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TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Properties

Boiling point	63-65 °C9 mm Hg(lit.)
Density	0.997 g/mL at 25 °C(lit.)
refractive index	n20/D 1.458(lit.)
Flash point	139 °F
storage temp.	2-8°C
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	0.997
InChI	InChI=1S/C8H12O2/c1-2-6-9-8-5-3-4-7-10-8/h1,8H,3-7H2
InChIKey	RNRIMDSCBRDPLC-UHFFFAOYSA-N
SMILES	C1(OCC#C)OCCCC1
CAS DataBase Reference	6089-04-9
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H315-H319-H226

Precautionary statements

P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235

Hazard Codes

Xi,F

Risk Statements

Safety Statements

26-27-28-36/37/39-16

RIDADR

UN 1993 3/PG 3

WGK Germany

TSCA

TSCA listed

HazardClass

3.2

PackingGroup

III

HS Code

29329900

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3

NFPA 704

	2
2		0

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	300810	Tetrahydro-2-(2-propynyloxy)-2H-pyran 98%	6089-04-9	25g	$83.4	2026-04-30	Buy
Sigma-Aldrich	300810	Tetrahydro-2-(2-propynyloxy)-2H-pyran 98%	6089-04-9	100g	$316	2026-04-30	Buy
TCI Chemical	P1624	2-(2-Propynyloxy)tetrahydropyran >97.0%(GC)	6089-04-9	25g	$146	2026-04-30	Buy
AstaTech	66503	TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 97%	6089-04-9	5G	$59	2026-04-30	Buy
AstaTech	66503	TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 97%	6089-04-9	25G	$116	2026-04-30	Buy

Product number	Packaging	Price	Buy
300810	25g	$83.4	Buy
300810	100g	$316	Buy
P1624	25g	$146	Buy
66503	5G	$59	Buy
66503	25G	$116	Buy

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

Tetrahydro-2-(2-propynyloxy)-2H-pyran was used in preparation of 1,3-dienyl acetal.

Synthesis Reference(s)

Chemistry Letters, 6, p. 817, 1977
Organic Syntheses, Coll. Vol. 7, p. 334, 1990
Synthetic Communications, 19, p. 901, 1989 DOI: 10.1080/00397918908051010

General Description

The anion formed by metalation at the acetylenic carbon reacts with a variety of electrophiles.

Synthesis

110-87-2

107-19-7

6089-04-9

General procedure for the synthesis of O-THP propargyl alcohol (Compound 18) from 3,4-dihydro-2H-pyran and 2-propyn-1-ol: Compound 18 was prepared according to literature procedure. To a solution of propargyl alcohol 17 (2.6 mL, 44.6 mmol) and p-toluenesulfonic acid monohydrate (0.09 g, 0.5 mmol) in dichloromethane (45 mL) was added dropwise 3,4-dihydro-2H-pyran (4.3 mL, 46.8 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 5 min before slowly warming up to room temperature and continued stirring for 1 h. The reaction mixture was then purified with aqueous solution of saturated 2H-pyran (4.3 mL). Subsequently, the reaction mixture was washed with saturated sodium bicarbonate solution (30 mL) and the aqueous layer was extracted with dichloromethane (45 mL). The organic layers were combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give compound 18 (6.1 g, 97.2% yield) as a yellow oil. Thin layer chromatography (TLC) Rf = 0.30 (hexane/ether, 95:5). 1H NMR (400 MHz, CDCl3): δ = 1.50-1.67 (m, 4H), 1.70-1.89 (m, 2H), 2.41 (t, J = 2.4 Hz, 1H), 3.52-3.57 (m, 1H), 3.82-3.87 (m , 1H), 4.27 (ddd, J = 2.4 Hz, 11.3 Hz, 15.8 Hz, 2H), 4.83 (t, J = 3.4 Hz, 1H). 13C NMR (100 MHz, CDCl3): δ = 19.0, 25.3, 30.2, 53.9, 61.9, 74.0, 79.7, 96.8. mass spectra (MS-CI): m/z calculated values. ): m/z calculated value C8H12O2 [M + H]+, 141; measured value: 141. The synthesis of this compound has been reported in the literature.

References

[1] Synlett, 2003, # 14, p. 2163 - 2166
[2] Tetrahedron, 2010, vol. 66, # 25, p. 4573 - 4576
[3] Synthesis, 2005, # 19, p. 3293 - 3296
[4] Journal of the Chinese Chemical Society, 2007, vol. 54, # 2, p. 525 - 532
[5] Journal of Organic Chemistry, 2009, vol. 74, # 4, p. 1531 - 1540

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN synthesis

Synthesis of TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN from Tetrahydropyran and Propargyl alcohol

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Preparation Products And Raw materials

Raw materials

2H-Pyran, 2-(bromomethoxy)tetrahydro- Tetrahydro-2-[[3-(trimethylsilyl)-2-propyn-1-yl]oxy]-2H-Pyran 4-[(tetrahydro-2H-pyran-2-yl)oxy]-2-Butyn-1-ol 2-HYDROXYTETRAHYDROPYRAN 3,6-dihydro-2H-pyran

Propargyl bromide Propargyl alcohol p-Toluenesulfonic acid 3-Butyn-1-ol Tetrahydropyran

3,4-Dihydro-2H-pyran

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Preparation Products

PROPARGYL BENZOATE 98 3-TRIMETHYLSILYL-2-PROPYN-1-OL Methyl-4-hydroxy-2-butynoate 1-(5-(((Tetrahydro-2H-pyran-2-yl)oxy)methyl)isoxazol-3-yl)ethanone

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
Kindchem(Nanjing)Co.,Ltd	+86-025-025-85281586 +8618651653755	sales@kindchem.cn	China	1226	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Kindchem(Nanjing)Co.,Ltd	58

View Lastest Price from TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-05	TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 6089-04-9	$80.00-800.00	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2025-11-18	TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 6089-04-9	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-09-25	TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 6089-04-9	$2.00-10.00	1KG	99%		Henan Fengda Chemical Co., Ltd

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
6089-04-9
$80.00-800.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
6089-04-9
$1.10
99.00%
Dideu Industries Group Limited

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
6089-04-9
$2.00-10.00
99%
Henan Fengda Chemical Co., Ltd

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Spectrum

TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN(6089-04-9)¹HNMR TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN(6089-04-9)Raman TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN(6089-04-9)FT-IR TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN(6089-04-9)IR

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2-(2-Propynyloxy)tetrahydro-2H-pyran TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN, 9 8% 2-(Propargyloxy)tetrahydropyran 2-Propargyloxane 2-Propynyl 2-pyranyl ether 2-Propynyl tetrahydro-2H-pyran-2-yl ether 3-(2'-Tetrahydropyranyloxy)propyne 3-(Tetrahydro-2-pyranyloxy)propyne Propargyl 2-tetrahydropyranyl ether Propargyl alcohol tetrahydropyranyl ether 2-prop-2-ynoxyoxane PROPARGYL ALCOHOL TETRAHYDRO-2H-PYRAN ETHER, 98%PROPARGYL ALCOHOL TETRAHYDRO-2H-PYRAN ETHER, 98%PROPARGYL ALCOHOL TETRAHYDRO-2H-PYRAN ETHER, 98% 2-(Prop-2-yn-1-yloxy)oxane (2S)-2-prop-2-ynoxyoxane 3-(tetrahydropyran-2'-yloxy)propyne Tetrahydro-2-(2-propyn-1-yloxy)-2H-pyran 2-(2-PROPYNYLOXY)TETRAHYDROPYRAN TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN TIMTEC-BB SBB008982 1-(2'-Tetrahydropyranyloxy)-2-propyne (Tetrahydro-2H-pyran-2-yl)(2-propynyl) ether 1-(3,4,5,6-Tetrahydro-2H-pyran-2-yloxy)-2-propyne Propargyl(tetrahydro-2H-pyran-2-yl) ether 2-(2-Propynyloxy)tetrahydro-2H-pyran,98% 2-(prop-2-ynyloxy)tetrahydro-2H-pyran 2-(2-Propynyloxy)tetrahydro-2H-pyran, 98% 5GR 2H-Pyran, tetrahydro-2-(2-propyn-1-yloxy)- Tetrahydro-2-(2-propynyloxy)pyran Tetrahydropyran-2-yloxypropyne Tetrahydropyranyl propargyl ether Tetrahydro-2-(2-propynyloxy)-2H-pyran 98% 2-(2-Propynyloxy)tetrahydropyran> TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN ISO 9001：2015 REACH Tetrahydro-2-(2-propynyloxy)-2H-pyran 2-(2-ynepropoxy)tetrahydropyran 2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran 2-prop-2-ynoxytetrahydropyran pent-4-ynoic acid PROPARGYL ALCOHOL TETRAHYDRO-2H-PYRAN ETHER Pyran 6089-04-9 089-04-9 6089-4-9 6089-04-09 C5H9OOCH2CCH Acetylenes Functionalized Acetylenes Building Blocks Heterocyclic Building Blocks Pyrans PYRAN API intermediates Boronic ester Organoborons Acetylenes Functionalized Acetylenes Building Blocks Heterocyclic Building Blocks