Lorvotuzumab Mertansine
- CAS No.
- 1008106-64-6
- Chemical Name:
- Lorvotuzumab Mertansine
- Synonyms
- Lorvotuzumab Mertansine;Research Grade Lorvotuzumab;Lorvotuzumab mertansine (ADC);Research Grade Lorvotuzumab (DHC98501)
- CBNumber:
- CB18080733
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | 0IVD6ASY0W |
|---|---|
| NCI Drug Dictionary | lorvotuzumab mertansine |
Lorvotuzumab Mertansine Chemical Properties,Uses,Production
Uses
Lorvotuzumab mertansine is an ADC consisting of a humanized N901 monoclonal antibody against CD56 bound to maytansinoid DM1 via a stable disulfide linker. Lorvotuzumab mertansine has antitumor activity[1].
in vivo
Lorvotuzumab mertansine (3-51 mg/kg, i.v., once) has potent anti-tumour activity in CB.17 SCID mice with SW2 SCLC xenograft tumor[1].
| Animal Model: | SW2 SCLC xenograft tumor CB.17 SCID mice |
| Dosage: | 3、17 and 51 mg/kg |
| Administration: | i.v., once |
| Result: | Showed high anti-tumor activity at a dose of 17 mg/kg with half of the animals being tumor free and complete tumor regression at a dose of 51 mg/kg. |
References
[1] Kathleen R Whiteman, et al. Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models. MAbs. 2014 Mar-Apr;6(2):556-66. DOI:10.4161/mabs.27756
Lorvotuzumab Mertansine Preparation Products And Raw materials
Raw materials
Preparation Products
Lorvotuzumab Mertansine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1566 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10308 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9868 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 6262 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Wuhan Peptide Core Biotechnology Co., Ltd | 027-65317797 13667154760 | 1096814016@qq.com | China | 10711 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 0731-13823398 15111215862 | 313359644@qq.com | China | 3805 | 58 |
| bioleaper | 4000880777 17585207275 | guojing@bioleaper.com | China | 5616 | 58 |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 17316404525 | 209533805@qq.com | China | 9981 | 58 |
| Atagenix Laboratories | 027-87008169 17762441161 | info@atagenix.com | China | 9914 | 58 |
