Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- Structure
2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- structure
CAS No.
1548286-45-8
Chemical Name:
2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-
Synonyms
2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-
CBNumber:
CB18151280
Molecular Formula:
C24H28N2O6
Molecular Weight:
440.49
MDL Number:
MOL File:
1548286-45-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 16:31:51
Request For Quotation

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- Properties

Boiling point 759.7±60.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
pka 13.93±0.20(Predicted)

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0173255 MK-8153 1548286-45-8 5mg $1137 2026-06-04 Buy
ChemScene CS-0173255 MK-8153 1548286-45-8 10mg $1820 2026-06-04 Buy
ChemScene CS-0173255 MK-8153 1548286-45-8 25mg $3792 2026-06-04 Buy
ChemScene CS-0173255 MK-8153 1548286-45-8 50mg $6066 2026-06-04 Buy
ChemScene CS-0173255 MK-8153 1548286-45-8 100mg $9696 2026-06-04 Buy
Product number Packaging Price Buy
CS-0173255 5mg $1137 Buy
CS-0173255 10mg $1820 Buy
CS-0173255 25mg $3792 Buy
CS-0173255 50mg $6066 Buy
CS-0173255 100mg $9696 Buy

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- Chemical Properties, Uses, Production

Uses

MK-8153 is a potent, selective and orally active inhibitor of renal outer medullary potassium channel (ROMK), with IC50s of 5 nM, 34 μM for ROMK electrophysiology (EP) and hERG EP, respectively. MK-8153 can be used as the diuretic/atriuretic[1].

in vivo

MK-8153 (0.1-10 mg/kg/d, p.o. once daily for 3 days) causes a dose-dependent decrease in systolic blood pressure of aged SHRs. MK-8153 shows diuretic effects in SHRs[1].
MK-8153 (2 mg/kg; p.o.) exhibits terminal elimination half-lives (rat 3.6, dog 9.1, Rhesus 3.3 h), bioavailability (rat 53%, dog ~100%, Rhesus 3.4%), and plasma clearance (rat 29.4, dog 8.7, Rhesus 58.3 mL/min/kg)[1].

Animal Model:Aged spontaneously hypertensive rats (SHRs)[1]
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:P.o. once daily for 3 days
Result:Observed the maximal lowering of systolic blood pressure (～24 mm Hg) by day 3 at the 3 mg/kg.
Dose-dependently increased the sodium excretion.

References

[1] Jiang J, et, al. Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. J Med Chem. 2021 May 26. DOI:10.1021/acs.jmedchem.1c00406

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK-8153 pictures 2026-05-11 MK-8153
1548286-45-8
 $2140.00-3520.00 10g TargetMol Chemicals Inc.
  • MK-8153 pictures
  • MK-8153
    1548286-45-8
  • $2140.00-3520.00
  • TargetMol Chemicals Inc.

1548286-45-8 (2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-) Related Search:

GlyT2-IN-1 BAPTA-AM Carbamazepine Glibenclamide W-7 Hydrochloride
Tannic acid

1of2

2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]- 1548286-45-8