tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate
- CAS No.
- 916421-36-8
- Chemical Name:
- tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate
- Synonyms
- 4-(1-Boc-3-azetidinyl)aniline;tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate;tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate 95%;3- (4-aminophenyl) azacyclobutane-1-tert-butyl carboxylate;3- (4-aminophenyl) azacyclobutane-1-carboxylic acid tert butyl ester;1-Azetidinecarboxylic acid, 3-(4-aminophenyl)-, 1,1-dimethylethyl ester;tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate , tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate
- CBNumber:
- CB1820863
- Molecular Formula:
- C14H20N2O2
- Molecular Weight:
- 248.32
- MDL Number:
- MFCD08751348
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RLB42136 | tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate | 916421-36-8 | 100mg | $328 | 2026-06-05 | Buy |
| Biosynth | RLB42136 | tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate | 916421-36-8 | 1g | $837.8 | 2026-06-05 | Buy |
| Synthonix | A39099 | tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate 95+% | 916421-36-8 | 50mg | $110 | 2026-05-06 | Buy |
| Synthonix | A39099 | tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate 95+% | 916421-36-8 | 100mg | $140 | 2026-05-06 | Buy |
| Synthonix | A39099 | tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate 95+% | 916421-36-8 | 250mg | $220 | 2026-05-06 | Buy |
tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate Chemical Properties, Uses, Production
Synthesis
883901-62-0
916421-36-8
General procedure for the synthesis of tert-butyl 3-(4-aminophenyl)azetidine-1-carboxylate from tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate: 10% Pd/C (0.320 g) and 3-(4-nitrophenyl)tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate (16) (2.14 g, 7.68 mmol) were mixed in a EtOAc (16 mL) solution was suspended under hydrogen atmosphere and the reaction was stirred for 18 hours. Subsequently, 10% Pd/C (1.00 g) was added supplementally and stirring was continued for 20 hours. Upon completion of the reaction, the mixture was filtered through a Celite pad, the filter cake was washed with EtOAc, and the filtrates were combined and concentrated in vacuo to afford the title compound 17 as a light yellow to cream solid (1.80 g, 94% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 7.12 (d, J = 8.3 Hz, 2H), 6.69 (dd, J = 6.5, 1.9 Hz, 2H), 4.29 (t, J = 8.7 Hz, 2H), 3.93 (dd, J = 8.4, 6.1 Hz, 2H), 3.65 (brs, 2H), 1.55- 1.68 (m, 1H), 1.48 (s, 9H).LCMS analysis: retention time 4.964 min; m/z 249 [M + H]+.
References
[1] Patent: WO2014/26243, 2014, A1. Location in patent: Page/Page column 89
[2] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 133; 134
tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai New Bo Biomedical Technology Co., LTD | 021-18800336901 15821600833 | muyouren139@163.com | China | 480 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| TaiChem Taizhou Limited | 052386810091 | zcwy9518@yeah.net | China | 3917 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chongqing Chemieliva Pharmaceutical Co., Ltd. | 18696571988 | amy.lei@chemieliva.com | China | 1341 | 60 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
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