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ChemicalBook >> CAS DataBase List >>4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro-

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro-

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- Structure
4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- structure
CAS No.
1234707-32-4
Chemical Name:
4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro-
Synonyms
Neutrophil elastase inhibitor 3;2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one;4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro-;2-(2-Bromophenyl)-5-chloro-4H-benzo[d][1,3]oxazin-4-one;5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one;2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one, 10 mM in DMSO;2 (2 bromophenyl) 5 chloro 4H 3,1 benzoxazin 4 one,2(2bromophenyl)5chloro4H3,1benzoxazin4one
CBNumber:
CB18214208
Molecular Formula:
C14H7BrClNO2
Molecular Weight:
336.57
MDL Number:
MFCD31800416
MOL File:
1234707-32-4.mol
Last updated:2025-04-18 09:51:43
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4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- Properties

Boiling point 436.9±38.0 °C(Predicted)
Density 1.65±0.1 g/cm3(Predicted)
pka -0.39±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- Chemical Properties,Uses,Production

Uses

Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1].

in vivo

Neutrophil elastase inhibitor 3 (compound 13, 1 mg/kg of body weight, intravenously) significantly attenuates the increase in myeloperoxidase (MPO) activity and edema in the lung of rats after trauma-hemorrhagic shock[1].

References

[1] Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem. 2010 Jul;45(7):3111-5. DOI:10.1016/j.ejmech.2010.03.046

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- synthesis

64460-57-7
1234707-32-4
Synthesis of 4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- from 4H-3,1-Benzoxazin-4-one, 5-chloro-2-phenyl-

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- Suppliers

Global( 27)Suppliers
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TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
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Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Chengdu Saint - Kay Biotechnology Co., Ltd. 58
Shanghai Han-Xiang Chemical Co., Ltd. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
ShangHai ChuanQian Chemcial Technique Centre 58
cjbscvictory 58
Hefei Mokai Pharmaceutical Technology Co., Ltd 58

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- Spectrum

4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro-(1234707-32-4)1HNMR
4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one 5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one 2-(2-Bromophenyl)-5-chloro-4H-benzo[d][1,3]oxazin-4-one 2 (2 bromophenyl) 5 chloro 4H 3,1 benzoxazin 4 one,2(2bromophenyl)5chloro4H3,1benzoxazin4one Neutrophil elastase inhibitor 3 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one, 10 mM in DMSO 1234707-32-4