GW441756
- CAS No.
- 504433-23-2
- Chemical Name:
- GW441756
- Synonyms
- Gw;CS-1085;W 441756;GW441758;GW 441756;GW441756, >98%;GW441756 USP/EP/BP;GW 441756/GW 441758;GW 441756; GW-441756;GW 441756, 10 mM in DMSO
- CBNumber:
- CB1839809
- Molecular Formula:
- C17H13N3O
- Molecular Weight:
- 275.3
- MDL Number:
- MFCD08703104
- MOL File:
- 504433-23-2.mol
- MSDS File:
- SDS
| Boiling point | 568.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| pka | 11.04±0.20(Predicted) |
| form | solid |
| color | Orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GW441756 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16915 | GW 441756 ≥95% | 504433-23-2 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 16915 | GW 441756 ≥95% | 504433-23-2 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 16915 | GW 441756 ≥95% | 504433-23-2 | 10mg | $113 | 2024-03-01 | Buy |
| Tocris | 2238 | GW441756 ≥99%(HPLC) | 504433-23-2 | 50 | $927 | 2021-12-16 | Buy |
| Tocris | 2238 | GW441756 ≥99%(HPLC) | 504433-23-2 | 10 | $221 | 2021-12-16 | Buy |
GW441756 Chemical Properties,Uses,Production
Description
GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).
Uses
GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.
Definition
ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.
Biological Activity
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
storage
Store at RT
References
[1] EDGAR R. WOOD. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 4: Pages 953-957. DOI:10.1016/j.bmcl.2003.12.002
[2] TAKUYA TAKEMOTO. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury[J]. Environmental toxicology and pharmacology, 2015, 40 1: Pages 199-205. DOI:10.1016/j.etap.2015.06.010
GW441756 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5744 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32430 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20802 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
