ChemicalBook >> CAS DataBase List >>5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione structure

CAS No.: 150728-12-4

Chemical Name:: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

Synonyms: Bosenta dione;Bosentan Impurity 13;Bosentan interMediate;5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4;5-(2-Methoxyphenoxy)-[2,2'-BipyriMidine]-4,6(1H,5H)-;(RS)-5-(2-methoxy-phenoxy)-1H-[22]bipyrimidine-4,6-dione;5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione;5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1h,5h)-dione;5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione;2,2'-Bipyrimidine]-4,6(1H,5H)-dione, 5-(2-methoxyphenoxy)-

CBNumber:: CB1855094

Molecular Formula:: C15H12N4O4

Molecular Weight:: 312.28

MDL Number:: MFCD09879703

MOL File:: 150728-12-4.mol

Last updated:2025-07-24 18:13:45

Product description	Number	Pack Size	Price
5-(2-Methoxyphenoxy)-[2,2''-bipyrimidine]-4,6(1H,5H)-dione	M226535	500mg	$75
5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione	7549AA	25g	$207
5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione 95+%	091105	250mg	$439
5-(2-METHOXYPHENOXY)-[2,2'-BIPYRIMIDINE]-4,6(1H,5H)-DIONE 95.00%	CHM0012388	1G	$808.5
5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione 95+%	091105	1g	$975
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5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Properties

Density	1.45
storage temp.	2-8°C
pka	6.23±0.40(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C15H12N4O4/c1-22-9-5-2-3-6-10(9)23-11-14(20)18-13(19-15(11)21)12-16-7-4-8-17-12/h2-8,11H,1H3,(H,18,19,20,21)
InChIKey	ZJMPECSQUMNGPA-UHFFFAOYSA-N
SMILES	C1(C2=NC=CC=N2)NC(=O)C(OC2=CC=CC=C2OC)C(=O)N=1
CAS DataBase Reference	150728-12-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933599590

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M226535	5-(2-Methoxyphenoxy)-[2,2''-bipyrimidine]-4,6(1H,5H)-dione	150728-12-4	500mg	$75	2021-12-16	Buy
AK Scientific	7549AA	5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione	150728-12-4	25g	$207	2021-12-16	Buy
Matrix Scientific	091105	5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione 95+%	150728-12-4	250mg	$439	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0012388	5-(2-METHOXYPHENOXY)-[2,2'-BIPYRIMIDINE]-4,6(1H,5H)-DIONE 95.00%	150728-12-4	1G	$808.5	2021-12-16	Buy
Matrix Scientific	091105	5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione 95+%	150728-12-4	1g	$975	2021-12-16	Buy

Product number	Packaging	Price	Buy
M226535	500mg	$75	Buy
7549AA	25g	$207	Buy
091105	250mg	$439	Buy
CHM0012388	1G	$808.5	Buy
091105	1g	$975	Buy

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Chemical Properties,Uses,Production

Synthesis

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

20730-58-9

2-Pyrimidinecarboximidamidemonobenzenesulfonate

16879-48-4

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

150728-12-4

Step 3: Synthesis of 5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidine-4,6(1H,5H)-dione Sodium (0.69 g, 30 mmol) was dissolved in anhydrous ethanol (40 mL) under nitrogen protection, followed by the addition of diethyl 2-(2-methoxyphenoxy)malonate (2.82 g, 10 mmol) and 2-amidinopyrimidinium benzenesulfonate (2.8 g, 10 mmol) to an ethanol (30 mL) solution, in that order. The reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the mixture was poured into ice water, acidified with 3M hydrochloric acid to pH ≈ 2, and then concentrated until a precipitate precipitated. The precipitate was collected by filtration, washed with water and dried to give 804 mg of yellow solid product in 25% yield. Product characterization data. 1H NMR (300 MHz, DMSO-d6) δ 3.84 (s, 3H), 6.68 (d, J = 6.9 Hz, 1H), 6.77 (t, J = 7.5 Hz, 1H), 6.91 (t, J = 7.5 Hz, 1H), 7.05 (d, J = 6.9 Hz, 1H), 9.05 (d, J = 5.1 Hz, 2H), 12.19 (br, 2H). 12.19 (br, 2H). ESI-MS, m/z = 313 (M + H+). Note: 5-(2-methoxyphenoxy)-[2,2'-dipyrimidinyl]-4,6(1H,5H)-dione can be prepared with reference to the method described in Example 1 step 3.

References

[1] Patent: US2008/242687, 2008, A1. Location in patent: Page/Page column 32; 34

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione synthesis

Synthesis of 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione from 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester and 2-Pyrimidinecarboximidamidemonobenzenesulfonate

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Preparation Products And Raw materials

Raw materials

2-Pyrimidinecarboximidamidemonobenzenesulfonate 2-Pyrimidinecarboximidic acid, methyl ester (9CI) 2-Cyanopyrimidine 2-Pyrimidinecarboxylicacid,ethylester(7CI,9CI) Dimethyl 2-(2-methoxyphenoxy)malonate

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester Guaiacol

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Preparation Products

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	029-81140587 +8618717328141	sales@yutbon.com	China	454	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15142	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
ANHUI WITOP BIOTECH CO., LTD	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-25	5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione 150728-12-4	US $0.00-0.00 / KG	1KG	99.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2021-07-13	5-(2-methoxyphenoxy)-[2,2"-Bipyrimidine]-4,6(1H,5H)-dione 150728-12-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	5-(2-methoxyphenoxy)-[2,2"-Bipyrimidine]-4,6(1H,5H)-dione 150728-12-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione
150728-12-4
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu New Materials Co. Ltd

5-(2-methoxyphenoxy)-[2,2"-Bipyrimidine]-4,6(1H,5H)-dione
150728-12-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-(2-methoxyphenoxy)-[2,2"-Bipyrimidine]-4,6(1H,5H)-dione
150728-12-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

150728-12-4(5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione)Related Search:

p-Anisidine p-Anisaldehyde 4-Methoxyphenol Guaiacol 4-Methoxybenzyl alcohol

(Trifluoromethoxy)benzene 4-Methoxybenzyl cyanide Anisole 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester 2-Cyanopyrimidine

Bosentan Bosentan Impurity 1 Diethyl chloromalonate Bosentan Impurity 17 Bosentan Impurity 5

Bosentan Impurity 7 Bosentan Impurity 2 Bosentan Impurity

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5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1h,5h)-dione 5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidine-4,6(1H,5H)-dione 5-(2-METHOXYPHENOXY)-2-(PYRIMIDIN-2-YL)PYRIMIDINE-4,6(1H,5H)-DIONE,PURITY:98% MIN(HPLC) 5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione 5-(O-methoxyphenoxy)-2-pymidin-2-yl)-4,6-(1H,5H)-pymidine dione Bosentan interMediate 5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)-1,4,5,6-tetrahydropyriMidine-4,6-dione 5-(2-Methoxyphenoxy)-[2,2'-BipyriMidine]-4,6(1H,5H)- Bosenta dione (RS)-5-(2-methoxy-phenoxy)-1H-[22]bipyrimidine-4,6-dione 5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4 Bosentan Impurity 13 2,2'-Bipyrimidine]-4,6(1H,5H)-dione, 5-(2-methoxyphenoxy)- 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione CAS NO.150728-12-4 CAS NO.150728-12-4 5- (2-Methoxyphenoxy) - [2,2 '- pyrimidine] -4,6 (1H, 5H) - dione 5- (2-Methoxyphenoxy) - [2,2 '- Dipyrimidine] -4,6 (1H, 5H) - dione 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione 150728-12-4 Heterocycle-Pyrimidine series pyrimidine